Examining extended human leukocyte antigen-G and HLA-F haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Examining extended human leukocyte antigen-G and HLA-F haplotypes : the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers. / Nilsson, Line Lynge; Scheike, Thomas; Langkilde, Cæcilie H.; Jørgensen, Nanna; Hornstrup, Micha B.; Perin, Trine L.; Funck, Tina; Lindhard, Anette; Hviid, Thomas Vauvert F.

In: Fertility and Sterility, Vol. 114, No. 3, 09.2020, p. 628-639.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Nilsson, LL, Scheike, T, Langkilde, CH, Jørgensen, N, Hornstrup, MB, Perin, TL, Funck, T, Lindhard, A & Hviid, TVF 2020, 'Examining extended human leukocyte antigen-G and HLA-F haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers', Fertility and Sterility, vol. 114, no. 3, pp. 628-639. https://doi.org/10.1016/j.fertnstert.2020.04.052

APA

Nilsson, L. L., Scheike, T., Langkilde, C. H., Jørgensen, N., Hornstrup, M. B., Perin, T. L., Funck, T., Lindhard, A., & Hviid, T. V. F. (2020). Examining extended human leukocyte antigen-G and HLA-F haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers. Fertility and Sterility, 114(3), 628-639. https://doi.org/10.1016/j.fertnstert.2020.04.052

Vancouver

Nilsson LL, Scheike T, Langkilde CH, Jørgensen N, Hornstrup MB, Perin TL et al. Examining extended human leukocyte antigen-G and HLA-F haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers. Fertility and Sterility. 2020 Sep;114(3):628-639. https://doi.org/10.1016/j.fertnstert.2020.04.052

Author

Nilsson, Line Lynge ; Scheike, Thomas ; Langkilde, Cæcilie H. ; Jørgensen, Nanna ; Hornstrup, Micha B. ; Perin, Trine L. ; Funck, Tina ; Lindhard, Anette ; Hviid, Thomas Vauvert F. / Examining extended human leukocyte antigen-G and HLA-F haplotypes : the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers. In: Fertility and Sterility. 2020 ; Vol. 114, No. 3. pp. 628-639.

Bibtex

@article{795c60a7ba8d435abc195d9ac196e302,
title = "Examining extended human leukocyte antigen-G and HLA-F haplotypes: the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers",
abstract = "Objective: To study the impact of extended human leukocyte antigen (HLA)-G and HLA-F haplotypes on time to pregnancy as measured by the number of treatment cycles in a cohort of couples in infertility treatment. Design: Prospective cohort study of couples undergoing infertility treatment. Setting: University hospital. Patient(s): A cohort of 127 couples and four single women in infertility treatment. Intervention(s): Next-generation sequencing of the HLA-G gene and genotyping of three HLA-F locus single-nucleotide polymorphisms (SNPs). Main Outcome Measure(s): Extended HLA-F.HLA-G haplotypes, HLA-G promoter haplotypes and HLA-G 3′UTR haplotypes and their association with time to pregnancy as measured by number of treatment cycles until achievement of pregnancy with a live birth. Linkage disequilibrium between HLA-G variations and three HLA-F locus SNPs that impact time to pregnancy. Result(s): The effect of the HLA-G 3′UTR haplotype, UTR-4, was significantly increased, or modified, if the partner was a carrier compared to being a noncarrier. Extended HLA-F.HLA-G haplotypes, HLA-G promoter haplotypes, and the HLA-G 14 bp indel of the female partners were not associated with time to pregnancy. However, a trend for an association of the HLA-G 14bp insertion allele with a higher frequency of miscarriage than the 14bp deletion allele was observed. Certain HLA-G variations are in linkage disequilibrium with three HLA-F locus SNPs that influence time to pregnancy. Conclusion(s): HLA-G UTR-4 is significantly associated with time to pregnancy in couples undergoing infertility treatment. The findings could imply that both male and female HLA class Ib genetics have clinical relevance in reproduction.",
keywords = "assisted reproduction technologies, gene variation, HLA-F, HLA-G, Infertility",
author = "Nilsson, {Line Lynge} and Thomas Scheike and Langkilde, {C{\ae}cilie H.} and Nanna J{\o}rgensen and Hornstrup, {Micha B.} and Perin, {Trine L.} and Tina Funck and Anette Lindhard and Hviid, {Thomas Vauvert F.}",
year = "2020",
month = sep,
doi = "10.1016/j.fertnstert.2020.04.052",
language = "English",
volume = "114",
pages = "628--639",
journal = "Sexuality, Reproduction and Menopause",
issn = "1546-2501",
publisher = "Elsevier",
number = "3",

}

RIS

TY - JOUR

T1 - Examining extended human leukocyte antigen-G and HLA-F haplotypes

T2 - the HLA-G UTR-4 haplotype is associated with shorter time to pregnancy in an infertility treatment setting when both female and male partners are carriers

AU - Nilsson, Line Lynge

AU - Scheike, Thomas

AU - Langkilde, Cæcilie H.

AU - Jørgensen, Nanna

AU - Hornstrup, Micha B.

AU - Perin, Trine L.

AU - Funck, Tina

AU - Lindhard, Anette

AU - Hviid, Thomas Vauvert F.

PY - 2020/9

Y1 - 2020/9

N2 - Objective: To study the impact of extended human leukocyte antigen (HLA)-G and HLA-F haplotypes on time to pregnancy as measured by the number of treatment cycles in a cohort of couples in infertility treatment. Design: Prospective cohort study of couples undergoing infertility treatment. Setting: University hospital. Patient(s): A cohort of 127 couples and four single women in infertility treatment. Intervention(s): Next-generation sequencing of the HLA-G gene and genotyping of three HLA-F locus single-nucleotide polymorphisms (SNPs). Main Outcome Measure(s): Extended HLA-F.HLA-G haplotypes, HLA-G promoter haplotypes and HLA-G 3′UTR haplotypes and their association with time to pregnancy as measured by number of treatment cycles until achievement of pregnancy with a live birth. Linkage disequilibrium between HLA-G variations and three HLA-F locus SNPs that impact time to pregnancy. Result(s): The effect of the HLA-G 3′UTR haplotype, UTR-4, was significantly increased, or modified, if the partner was a carrier compared to being a noncarrier. Extended HLA-F.HLA-G haplotypes, HLA-G promoter haplotypes, and the HLA-G 14 bp indel of the female partners were not associated with time to pregnancy. However, a trend for an association of the HLA-G 14bp insertion allele with a higher frequency of miscarriage than the 14bp deletion allele was observed. Certain HLA-G variations are in linkage disequilibrium with three HLA-F locus SNPs that influence time to pregnancy. Conclusion(s): HLA-G UTR-4 is significantly associated with time to pregnancy in couples undergoing infertility treatment. The findings could imply that both male and female HLA class Ib genetics have clinical relevance in reproduction.

AB - Objective: To study the impact of extended human leukocyte antigen (HLA)-G and HLA-F haplotypes on time to pregnancy as measured by the number of treatment cycles in a cohort of couples in infertility treatment. Design: Prospective cohort study of couples undergoing infertility treatment. Setting: University hospital. Patient(s): A cohort of 127 couples and four single women in infertility treatment. Intervention(s): Next-generation sequencing of the HLA-G gene and genotyping of three HLA-F locus single-nucleotide polymorphisms (SNPs). Main Outcome Measure(s): Extended HLA-F.HLA-G haplotypes, HLA-G promoter haplotypes and HLA-G 3′UTR haplotypes and their association with time to pregnancy as measured by number of treatment cycles until achievement of pregnancy with a live birth. Linkage disequilibrium between HLA-G variations and three HLA-F locus SNPs that impact time to pregnancy. Result(s): The effect of the HLA-G 3′UTR haplotype, UTR-4, was significantly increased, or modified, if the partner was a carrier compared to being a noncarrier. Extended HLA-F.HLA-G haplotypes, HLA-G promoter haplotypes, and the HLA-G 14 bp indel of the female partners were not associated with time to pregnancy. However, a trend for an association of the HLA-G 14bp insertion allele with a higher frequency of miscarriage than the 14bp deletion allele was observed. Certain HLA-G variations are in linkage disequilibrium with three HLA-F locus SNPs that influence time to pregnancy. Conclusion(s): HLA-G UTR-4 is significantly associated with time to pregnancy in couples undergoing infertility treatment. The findings could imply that both male and female HLA class Ib genetics have clinical relevance in reproduction.

KW - assisted reproduction technologies

KW - gene variation

KW - HLA-F

KW - HLA-G

KW - Infertility

U2 - 10.1016/j.fertnstert.2020.04.052

DO - 10.1016/j.fertnstert.2020.04.052

M3 - Journal article

C2 - 32912613

AN - SCOPUS:85090318710

VL - 114

SP - 628

EP - 639

JO - Sexuality, Reproduction and Menopause

JF - Sexuality, Reproduction and Menopause

SN - 1546-2501

IS - 3

ER -

ID: 248424053