First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

First total synthesis of (+/-)-3-hydroxy-11-norcytisine : Structure confirmation and biological characterization. / Yohannes, Daniel; Hansen, Camilla Petrycer; Akireddy, Srinivasa Rao; Hauser, Terry A; Kiser, Melanie N; Gurnon, Nicholas J; Day, Cynthia S; Bhatti, Balwinder; Caldwell, William S.

In: Organic Letters, Vol. 10, No. 23, 2008, p. 5353-5356.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Yohannes, D, Hansen, CP, Akireddy, SR, Hauser, TA, Kiser, MN, Gurnon, NJ, Day, CS, Bhatti, B & Caldwell, WS 2008, 'First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization', Organic Letters, vol. 10, no. 23, pp. 5353-5356. https://doi.org/10.1021/ol802145b

APA

Yohannes, D., Hansen, C. P., Akireddy, S. R., Hauser, T. A., Kiser, M. N., Gurnon, N. J., Day, C. S., Bhatti, B., & Caldwell, W. S. (2008). First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization. Organic Letters, 10(23), 5353-5356. https://doi.org/10.1021/ol802145b

Vancouver

Yohannes D, Hansen CP, Akireddy SR, Hauser TA, Kiser MN, Gurnon NJ et al. First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization. Organic Letters. 2008;10(23):5353-5356. https://doi.org/10.1021/ol802145b

Author

Yohannes, Daniel ; Hansen, Camilla Petrycer ; Akireddy, Srinivasa Rao ; Hauser, Terry A ; Kiser, Melanie N ; Gurnon, Nicholas J ; Day, Cynthia S ; Bhatti, Balwinder ; Caldwell, William S. / First total synthesis of (+/-)-3-hydroxy-11-norcytisine : Structure confirmation and biological characterization. In: Organic Letters. 2008 ; Vol. 10, No. 23. pp. 5353-5356.

Bibtex

@article{af783f70f44f11ddbf70000ea68e967b,
title = "First total synthesis of (+/-)-3-hydroxy-11-norcytisine: Structure confirmation and biological characterization",
abstract = "The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.",
keywords = "Former Faculty of Pharmaceutical Sciences",
author = "Daniel Yohannes and Hansen, {Camilla Petrycer} and Akireddy, {Srinivasa Rao} and Hauser, {Terry A} and Kiser, {Melanie N} and Gurnon, {Nicholas J} and Day, {Cynthia S} and Balwinder Bhatti and Caldwell, {William S}",
year = "2008",
doi = "10.1021/ol802145b",
language = "English",
volume = "10",
pages = "5353--5356",
journal = "Organic Letters",
issn = "1523-7060",
publisher = "American Chemical Society",
number = "23",

}

RIS

TY - JOUR

T1 - First total synthesis of (+/-)-3-hydroxy-11-norcytisine

T2 - Structure confirmation and biological characterization

AU - Yohannes, Daniel

AU - Hansen, Camilla Petrycer

AU - Akireddy, Srinivasa Rao

AU - Hauser, Terry A

AU - Kiser, Melanie N

AU - Gurnon, Nicholas J

AU - Day, Cynthia S

AU - Bhatti, Balwinder

AU - Caldwell, William S

PY - 2008

Y1 - 2008

N2 - The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.

AB - The first total synthesis of the natural product 3-hydroxy-11-norcytisine ( 1), structurally related to cytisine ( 2), a benchmark ligand at neuronal nicotinic acetylcholine receptors (NNRs), has been achieved. The synthesis permits the unambiguous confirmation of the structure originally proposed for 1 and has enabled initial biological characterization of 1 and its related compounds against NNRs.

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1021/ol802145b

DO - 10.1021/ol802145b

M3 - Journal article

C2 - 19007172

VL - 10

SP - 5353

EP - 5356

JO - Organic Letters

JF - Organic Letters

SN - 1523-7060

IS - 23

ER -

ID: 10162587