Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts
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Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts. / Lund-Blix, Nicolai A.; Sander, Stine Dydensborg; Størdal, Ketil; Nybo Andersen, Anne-Marie; Rønningen, Kjersti S.; Joner, Geir; Skrivarhaug, Torild; Njølstad, Pal R.; Husby, Steffen; Stene, Lars C.
In: Diabetes Care, Vol. 40, No. 7, 07.2017, p. 920-927.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Infant Feeding and Risk of Type 1 Diabetes in Two Large Scandinavian Birth Cohorts
AU - Lund-Blix, Nicolai A.
AU - Sander, Stine Dydensborg
AU - Størdal, Ketil
AU - Nybo Andersen, Anne-Marie
AU - Rønningen, Kjersti S.
AU - Joner, Geir
AU - Skrivarhaug, Torild
AU - Njølstad, Pal R.
AU - Husby, Steffen
AU - Stene, Lars C.
PY - 2017/7
Y1 - 2017/7
N2 - OBJECTIVE: Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes.RESEARCH DESIGN AND METHODS: We included two population-based cohorts of children followed from birth (1996–2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC). Parents reported infant dietary practices when their child was 6 and 18 months old. The outcome was clinical type 1 diabetes, ascertained from nationwide childhood diabetes registries. Hazard ratios (HRs) were estimated using Cox regression.RESULTS: Type 1 diabetes was identified in 504 children during follow-up, and the incidence of type 1 diabetes per 100,000 person-years was 30.5 in the Norwegian cohort and 23.5 in the Danish cohort. Children who were never breastfed had a twofold increased risk of type 1 diabetes compared with those who were breastfed (HR 2.29 [95% CI 1.14–4.61] for no breastfeeding vs. any breastfeeding for ≥12 months). Among those who were breastfed, however, the incidence of type 1 diabetes was independent of duration of both full breastfeeding (HR per month 0.99 [95% CI 0.97–1.01]) and any breastfeeding (0.97 [0.92–1.03]).CONCLUSIONS: Suggestive evidence supports the contention that breastfeeding reduces the risk of type 1 diabetes. Among those who were breastfed, however, no evidence indicated that prolonging full or any breastfeeding was associated with a reduced risk of type 1 diabetes.
AB - OBJECTIVE: Our aim was to study the relation between the duration of full and any breastfeeding and risk of type 1 diabetes.RESEARCH DESIGN AND METHODS: We included two population-based cohorts of children followed from birth (1996–2009) to 2014 (Denmark) or 2015 (Norway). We analyzed data from a total of 155,392 children participating in the Norwegian Mother and Child Cohort Study (MoBa) and the Danish National Birth Cohort (DNBC). Parents reported infant dietary practices when their child was 6 and 18 months old. The outcome was clinical type 1 diabetes, ascertained from nationwide childhood diabetes registries. Hazard ratios (HRs) were estimated using Cox regression.RESULTS: Type 1 diabetes was identified in 504 children during follow-up, and the incidence of type 1 diabetes per 100,000 person-years was 30.5 in the Norwegian cohort and 23.5 in the Danish cohort. Children who were never breastfed had a twofold increased risk of type 1 diabetes compared with those who were breastfed (HR 2.29 [95% CI 1.14–4.61] for no breastfeeding vs. any breastfeeding for ≥12 months). Among those who were breastfed, however, the incidence of type 1 diabetes was independent of duration of both full breastfeeding (HR per month 0.99 [95% CI 0.97–1.01]) and any breastfeeding (0.97 [0.92–1.03]).CONCLUSIONS: Suggestive evidence supports the contention that breastfeeding reduces the risk of type 1 diabetes. Among those who were breastfed, however, no evidence indicated that prolonging full or any breastfeeding was associated with a reduced risk of type 1 diabetes.
U2 - 10.2337/dc17-0016
DO - 10.2337/dc17-0016
M3 - Journal article
C2 - 28487451
VL - 40
SP - 920
EP - 927
JO - Diabetes Care
JF - Diabetes Care
SN - 0149-5992
IS - 7
ER -
ID: 188197324