Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke

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Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke. / Enevold, C; Nielsen, C. H.; Molbo, D.; Lund, R.; Bendtzen, K; Fiehn, Nils-Erik; Holmstrup, P.

In: Scientific Reports, Vol. 9, No. 1, 6283, 2019.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Enevold, C, Nielsen, CH, Molbo, D, Lund, R, Bendtzen, K, Fiehn, N-E & Holmstrup, P 2019, 'Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke', Scientific Reports, vol. 9, no. 1, 6283. https://doi.org/10.1038/s41598-019-42594-z

APA

Enevold, C., Nielsen, C. H., Molbo, D., Lund, R., Bendtzen, K., Fiehn, N-E., & Holmstrup, P. (2019). Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke. Scientific Reports, 9(1), [6283]. https://doi.org/10.1038/s41598-019-42594-z

Vancouver

Enevold C, Nielsen CH, Molbo D, Lund R, Bendtzen K, Fiehn N-E et al. Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke. Scientific Reports. 2019;9(1). 6283. https://doi.org/10.1038/s41598-019-42594-z

Author

Enevold, C ; Nielsen, C. H. ; Molbo, D. ; Lund, R. ; Bendtzen, K ; Fiehn, Nils-Erik ; Holmstrup, P. / Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke. In: Scientific Reports. 2019 ; Vol. 9, No. 1.

Bibtex

@article{8cd68d5976304ae294dad1b96db9067b,
title = "Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke",
abstract = "The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. No significant association between blood group phenotype and periodontitis was detected, nor were previously reported associations between blood group phenotype and hypertension, ischaemic heart disease, stroke, and obesity confirmed. This may, at least partly, be attributed to differences in study type, outcome definitions, cohort sizes, and population attributable factors. However, our results suggested a strong association between self-reported stroke and the Lewis (a-b-) phenotype (P = 0.0002, OR: 22.28; CI 95: 4.72-131.63).",
author = "C Enevold and Nielsen, {C. H.} and D. Molbo and R. Lund and K Bendtzen and Nils-Erik Fiehn and P Holmstrup",
year = "2019",
doi = "10.1038/s41598-019-42594-z",
language = "English",
volume = "9",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke

AU - Enevold, C

AU - Nielsen, C. H.

AU - Molbo, D.

AU - Lund, R.

AU - Bendtzen, K

AU - Fiehn, Nils-Erik

AU - Holmstrup, P

PY - 2019

Y1 - 2019

N2 - The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. No significant association between blood group phenotype and periodontitis was detected, nor were previously reported associations between blood group phenotype and hypertension, ischaemic heart disease, stroke, and obesity confirmed. This may, at least partly, be attributed to differences in study type, outcome definitions, cohort sizes, and population attributable factors. However, our results suggested a strong association between self-reported stroke and the Lewis (a-b-) phenotype (P = 0.0002, OR: 22.28; CI 95: 4.72-131.63).

AB - The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. No significant association between blood group phenotype and periodontitis was detected, nor were previously reported associations between blood group phenotype and hypertension, ischaemic heart disease, stroke, and obesity confirmed. This may, at least partly, be attributed to differences in study type, outcome definitions, cohort sizes, and population attributable factors. However, our results suggested a strong association between self-reported stroke and the Lewis (a-b-) phenotype (P = 0.0002, OR: 22.28; CI 95: 4.72-131.63).

U2 - 10.1038/s41598-019-42594-z

DO - 10.1038/s41598-019-42594-z

M3 - Journal article

VL - 9

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 6283

ER -

ID: 217154091