Lewis and AB0 blood group-phenotypes in periodontitis, cardiovascular disease, obesity and stroke

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C Enevold, C. H. Nielsen, D. Molbo, R. Lund, K Bendtzen, Nils-Erik Fiehn, P Holmstrup

The AB0 blood group has been linked to ischaemic heart disease, stroke, and periodontal disease, while the Lewis blood group has been linked to ischaemic heart disease and obesity, all of which have been associated with periodontitis. AB0 or Lewis blood group phenotype may therefore constitute common hereditary components predisposing to these disorders. In this study, we investigated if blood group phenotype associated with periodontitis in a subpopulation consisting of 702 participants from a Danish cross-sectional cohort and, secondarily, attempted to confirm their association with hypertension, ischaemic heart disease, stroke, and obesity. No significant association between blood group phenotype and periodontitis was detected, nor were previously reported associations between blood group phenotype and hypertension, ischaemic heart disease, stroke, and obesity confirmed. This may, at least partly, be attributed to differences in study type, outcome definitions, cohort sizes, and population attributable factors. However, our results suggested a strong association between self-reported stroke and the Lewis (a-b-) phenotype (P = 0.0002, OR: 22.28; CI 95: 4.72-131.63).

Original languageEnglish
Article number6283
JournalScientific Reports
Volume9
Issue number1
Number of pages7
ISSN2045-2322
DOIs
Publication statusPublished - 2019

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