Long-term impact of preeclampsia on maternal endometrial cancer risk
Research output: Contribution to journal › Letter › Research › peer-review
BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk.
METHODS: We conducted a case-control study of 523 Danish women with endometrial cancer and 52 299controls during 1978-2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models.
RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk (OR=1.11 (95% CI 0.68-1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29-5.38)).
CONCLUSIONS: Although we report no obvious association between preeclampsia and endometrial cancer, studying the subset of early-onset preeclampsia may prove fruitful in further understanding the aetiology of endometrial cancer.
|Journal||B J C|
|Number of pages||4|
|Publication status||Published - 2016|
- Adolescent, Adult, Case-Control Studies, Denmark, Endometrial Neoplasms, Female, Follow-Up Studies, Humans, Incidence, Middle Aged, Pre-Eclampsia, Pregnancy, Prognosis, Risk Factors, Young Adult, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't