Long-term impact of preeclampsia on maternal endometrial cancer risk
Research output: Contribution to journal › Letter › peer-review
BACKGROUND: Endometrial cancer is mainly dependent on oestrogen exposure. Preeclampsia has shown to reduce oestrogen levels hence preeclampsia may affect later endometrial cancer risk.
METHODS: We conducted a case-control study of 523 Danish women with endometrial cancer and 52 299controls during 1978-2010. The association between preeclampsia and later endometrial cancer was evaluated overall and according to preeclampsia onset and type of endometrial cancer in conditional logistic regression models.
RESULTS: We observed no overall association between preeclampsia and endometrial cancer risk (OR=1.11 (95% CI 0.68-1.81)). This was true for all endometrial cancer subtypes. In an analysis of preeclampsia onset, however, we report a markedly increased risk of endometrial cancer following early-onset preeclampsia (OR=2.64 (95% CI 1.29-5.38)).
CONCLUSIONS: Although we report no obvious association between preeclampsia and endometrial cancer, studying the subset of early-onset preeclampsia may prove fruitful in further understanding the aetiology of endometrial cancer.
Original language | English |
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Journal | B J C |
Volume | 114 |
Issue number | 7 |
Pages (from-to) | 809-812 |
Number of pages | 4 |
ISSN | 0007-0920 |
DOIs | |
Publication status | Published - 2016 |
- Adolescent, Adult, Case-Control Studies, Denmark, Endometrial Neoplasms, Female, Follow-Up Studies, Humans, Incidence, Middle Aged, Pre-Eclampsia, Pregnancy, Prognosis, Risk Factors, Young Adult, Comparative Study, Journal Article, Randomized Controlled Trial, Research Support, Non-U.S. Gov't
Research areas
ID: 165718869