Multimodal assessment of precentral anodal TDCS: Individual rise in supplementary motor activity scales with increase in corticospinal excitability
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Multimodal assessment of precentral anodal TDCS: Individual rise in supplementary motor activity scales with increase in corticospinal excitability. / Karabanov, Anke Ninija; Shindo, Keiichiro; Shindo, Yuko; Raffin, Estelle; Siebner, Hartwig Roman.
In: Frontiers in Human Neuroscience, Vol. 15, 639274, 2021.Research output: Contribution to journal › Journal article › Research › peer-review
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T1 - Multimodal assessment of precentral anodal TDCS: Individual rise in supplementary motor activity scales with increase in corticospinal excitability
AU - Karabanov, Anke Ninija
AU - Shindo, Keiichiro
AU - Shindo, Yuko
AU - Raffin, Estelle
AU - Siebner, Hartwig Roman
N1 - Copyright © 2021 Karabanov, Shindo, Shindo, Raffin and Siebner.
PY - 2021
Y1 - 2021
N2 - Background: Transcranial direct current stimulation (TDCS) targeting the primary motor hand area (M1-HAND) may induce lasting shifts in corticospinal excitability, but after-effects show substantial inter-individual variability. Functional magnetic resonance imaging (fMRI) can probe after-effects of TDCS on regional neural activity on a whole-brain level.Objective: Using a double-blinded cross-over design, we investigated whether the individual change in corticospinal excitability after TDCS of M1-HAND is associated with changes in task-related regional activity in cortical motor areas.Methods: Seventeen healthy volunteers (10 women) received 20 min of real (0.75 mA) or sham TDCS on separate days in randomized order. Real and sham TDCS used the classic bipolar set-up with the anode placed over right M1-HAND. Before and after each TDCS session, we recorded motor evoked potentials (MEP) from the relaxed left first dorsal interosseus muscle after single-pulse transcranial magnetic stimulation(TMS) of left M1-HAND and performed whole-brain fMRI at 3 Tesla while participants completed a visuomotor tracking task with their left hand. We also assessed the difference in MEP latency when applying anterior-posterior and latero-medial TMS pulses to the precentral hand knob (AP-LM MEP latency).Results: Real TDCS had no consistent aftereffects on mean MEP amplitude, task-related activity or motor performance. Individual changes in MEP amplitude, measured directly after real TDCS showed a positive linear relationship with individual changes in task-related activity in the supplementary motor area and AP-LM MEP latency.Conclusion: Functional aftereffects of classical bipolar anodal TDCS of M1-HAND on the motor system vary substantially across individuals. Physiological features upstream from the primary motor cortex may determine how anodal TDCS changes corticospinal excitability.
AB - Background: Transcranial direct current stimulation (TDCS) targeting the primary motor hand area (M1-HAND) may induce lasting shifts in corticospinal excitability, but after-effects show substantial inter-individual variability. Functional magnetic resonance imaging (fMRI) can probe after-effects of TDCS on regional neural activity on a whole-brain level.Objective: Using a double-blinded cross-over design, we investigated whether the individual change in corticospinal excitability after TDCS of M1-HAND is associated with changes in task-related regional activity in cortical motor areas.Methods: Seventeen healthy volunteers (10 women) received 20 min of real (0.75 mA) or sham TDCS on separate days in randomized order. Real and sham TDCS used the classic bipolar set-up with the anode placed over right M1-HAND. Before and after each TDCS session, we recorded motor evoked potentials (MEP) from the relaxed left first dorsal interosseus muscle after single-pulse transcranial magnetic stimulation(TMS) of left M1-HAND and performed whole-brain fMRI at 3 Tesla while participants completed a visuomotor tracking task with their left hand. We also assessed the difference in MEP latency when applying anterior-posterior and latero-medial TMS pulses to the precentral hand knob (AP-LM MEP latency).Results: Real TDCS had no consistent aftereffects on mean MEP amplitude, task-related activity or motor performance. Individual changes in MEP amplitude, measured directly after real TDCS showed a positive linear relationship with individual changes in task-related activity in the supplementary motor area and AP-LM MEP latency.Conclusion: Functional aftereffects of classical bipolar anodal TDCS of M1-HAND on the motor system vary substantially across individuals. Physiological features upstream from the primary motor cortex may determine how anodal TDCS changes corticospinal excitability.
KW - Faculty of Science
KW - Functional magnetic resonance imaging (fMRI)
KW - Inter-individual variability
KW - Motor evoked potentials
KW - Primary motor cortex (M1)
KW - Supplementary motor area (SMA)
KW - Transcranial direct current stimulation (tDCS)
KW - Non-invasive brain stimulation
KW - Transcrancial magnetic stimulation (TMS)
U2 - 10.3389/fnhum.2021.639274
DO - 10.3389/fnhum.2021.639274
M3 - Journal article
C2 - 33762917
VL - 15
JO - Frontiers in Human Neuroscience
JF - Frontiers in Human Neuroscience
SN - 1662-5161
M1 - 639274
ER -
ID: 258892501