Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands

Research output: Contribution to journalJournal articleResearchpeer-review

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Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands. / Krogsgaard-Larsen, Niels; Jensen, Anders A.; Kehler, Jan.

In: Bioorganic & Medicinal Chemistry Letters, Vol. 20, No. 18, 15.09.2010, p. 5431-5433.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Krogsgaard-Larsen, N, Jensen, AA & Kehler, J 2010, 'Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands', Bioorganic & Medicinal Chemistry Letters, vol. 20, no. 18, pp. 5431-5433. https://doi.org/10.1016/j.bmcl.2010.07.105

APA

Krogsgaard-Larsen, N., Jensen, A. A., & Kehler, J. (2010). Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands. Bioorganic & Medicinal Chemistry Letters, 20(18), 5431-5433. https://doi.org/10.1016/j.bmcl.2010.07.105

Vancouver

Krogsgaard-Larsen N, Jensen AA, Kehler J. Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands. Bioorganic & Medicinal Chemistry Letters. 2010 Sep 15;20(18):5431-5433. https://doi.org/10.1016/j.bmcl.2010.07.105

Author

Krogsgaard-Larsen, Niels ; Jensen, Anders A. ; Kehler, Jan. / Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands. In: Bioorganic & Medicinal Chemistry Letters. 2010 ; Vol. 20, No. 18. pp. 5431-5433.

Bibtex

@article{1183ced1ea714dd7a89b4fe7848a7ce2,
title = "Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands",
abstract = "Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.",
keywords = "Cell Line, Hela Cells, Humans, Indoles, Ligands, Protein Binding, Pyrazines, Receptor, Serotonin, 5-HT2C, Receptors, Serotonin, Structure-Activity Relationship, Former Faculty of Pharmaceutical Sciences",
author = "Niels Krogsgaard-Larsen and Jensen, {Anders A.} and Jan Kehler",
note = "Keywords: carbene, C-H insertion, serotonin, 5-HT2C, 5-HT6, 1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indole",
year = "2010",
month = "9",
day = "15",
doi = "10.1016/j.bmcl.2010.07.105",
language = "English",
volume = "20",
pages = "5431--5433",
journal = "Bioorganic & Medicinal Chemistry Letters",
issn = "0960-894X",
publisher = "Pergamon Press",
number = "18",

}

RIS

TY - JOUR

T1 - Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles as dual serotonin 5-HT2C and 5-HT6 receptor ligands

AU - Krogsgaard-Larsen, Niels

AU - Jensen, Anders A.

AU - Kehler, Jan

N1 - Keywords: carbene, C-H insertion, serotonin, 5-HT2C, 5-HT6, 1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indole

PY - 2010/9/15

Y1 - 2010/9/15

N2 - Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.

AB - Novel 7-phenylsulfanyl-1,2,3,4,10,10a-hexahydro-pyrazino[1,2-a]indoles are synthesized using a six-step protocol. Notably, the synthesis route make use of a new and improved ring-closing methodology for the assembly of the hexahydro-pyrazino[1,2-a]indole scaffold, which is based on intramolecular C-H insertion of a carbene. The compounds act as dual serotonin 5-HT2C- and 5-HT6-ligands.

KW - Cell Line

KW - Hela Cells

KW - Humans

KW - Indoles

KW - Ligands

KW - Protein Binding

KW - Pyrazines

KW - Receptor, Serotonin, 5-HT2C

KW - Receptors, Serotonin

KW - Structure-Activity Relationship

KW - Former Faculty of Pharmaceutical Sciences

U2 - 10.1016/j.bmcl.2010.07.105

DO - 10.1016/j.bmcl.2010.07.105

M3 - Journal article

C2 - 20719507

VL - 20

SP - 5431

EP - 5433

JO - Bioorganic & Medicinal Chemistry Letters

JF - Bioorganic & Medicinal Chemistry Letters

SN - 0960-894X

IS - 18

ER -

ID: 34207860