Preeclampsia and scleroderma: a prospective nationwide analysis

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Mads Kamper-Jørgensen, Hilary S Gammill, J Lee Nelson

INTRODUCTION: In a preliminary case-control study, women with scleroderma more frequently reported having had hypertensive complications during pregnancy compared with healthy women.

MATERIAL AND METHODS: To prospectively investigate this possible association, we conducted a nation-wide cohort analysis of a major hypertensive complication during pregnancy, namely preeclampsia, and later scleroderma. Analyses were based on Danish register-based birth and hospital contact data on preeclampsia and scleroderma. We followed 778,758 women from time of giving birth between 1978 and 2010 to end of follow-up, emigration, death, or scleroderma diagnosis, whichever occurred first. The association was evaluated by incidence rate ratios, obtained in Poisson regression models.

RESULTS: We report that preeclampsia is associated with a 69% significantly increased risk of later developing scleroderma.

CONCLUSIONS: Though these findings do not impact clinical care directly, the association of preeclampsia with scleroderma underscores the significant relation of preeclampsia and other adverse pregnancy outcomes with later disease in women and should be included in patient counseling and education.

Original languageEnglish
JournalActa Obstetricia et Gynecologica Scandinavica
Volume97
Issue number5
Pages (from-to)587-590
Number of pages4
ISSN0001-6349
DOIs
Publication statusPublished - 2018

ID: 198661890