Synthesis of the thiazole-thiazoline fragment of largazole analogues

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Synthesis of the thiazole-thiazoline fragment of largazole analogues. / Diness, Frederik; Nielsen, Daniel Skovhaur; Fairlie, David P.

In: Journal of Organic Chemistry, Vol. 76, No. 23, 02.12.2011, p. 9845-9851.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Diness, F, Nielsen, DS & Fairlie, DP 2011, 'Synthesis of the thiazole-thiazoline fragment of largazole analogues', Journal of Organic Chemistry, vol. 76, no. 23, pp. 9845-9851. https://doi.org/10.1021/jo201675r

APA

Diness, F., Nielsen, D. S., & Fairlie, D. P. (2011). Synthesis of the thiazole-thiazoline fragment of largazole analogues. Journal of Organic Chemistry, 76(23), 9845-9851. https://doi.org/10.1021/jo201675r

Vancouver

Diness F, Nielsen DS, Fairlie DP. Synthesis of the thiazole-thiazoline fragment of largazole analogues. Journal of Organic Chemistry. 2011 Dec 2;76(23):9845-9851. https://doi.org/10.1021/jo201675r

Author

Diness, Frederik ; Nielsen, Daniel Skovhaur ; Fairlie, David P. / Synthesis of the thiazole-thiazoline fragment of largazole analogues. In: Journal of Organic Chemistry. 2011 ; Vol. 76, No. 23. pp. 9845-9851.

Bibtex

@article{0a082f98f66a44759c5e94637f4f1f51,
title = "Synthesis of the thiazole-thiazoline fragment of largazole analogues",
abstract = "The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.",
keywords = "The Faculty of Pharmaceutical Sciences",
author = "Frederik Diness and Nielsen, {Daniel Skovhaur} and Fairlie, {David P}",
year = "2011",
month = "12",
day = "2",
doi = "10.1021/jo201675r",
language = "English",
volume = "76",
pages = "9845--9851",
journal = "Journal of Organic Chemistry",
issn = "0022-3263",
publisher = "American Chemical Society",
number = "23",

}

RIS

TY - JOUR

T1 - Synthesis of the thiazole-thiazoline fragment of largazole analogues

AU - Diness, Frederik

AU - Nielsen, Daniel Skovhaur

AU - Fairlie, David P

PY - 2011/12/2

Y1 - 2011/12/2

N2 - The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.

AB - The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.

KW - The Faculty of Pharmaceutical Sciences

U2 - 10.1021/jo201675r

DO - 10.1021/jo201675r

M3 - Journal article

VL - 76

SP - 9845

EP - 9851

JO - Journal of Organic Chemistry

JF - Journal of Organic Chemistry

SN - 0022-3263

IS - 23

ER -

ID: 35442124