Synthesis of the thiazole-thiazoline fragment of largazole analogues

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Frederik Diness, Daniel Skovhaur Nielsen, David P Fairlie

The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.
Original languageEnglish
JournalJournal of Organic Chemistry
Volume76
Issue number23
Pages (from-to)9845-9851
ISSN0022-3263
DOIs
Publication statusPublished - 2 Dec 2011

ID: 35442124