Synthesis of the thiazole-thiazoline fragment of largazole analogues
Research output: Contribution to journal › Journal article › Research › peer-review
Frederik Diness, Daniel Skovhaur Nielsen, David P Fairlie
The thiazole-thiazoline fragment of the marine natural product largazole, a potent histone deacetylase 1 inhibitor, has been synthesized in five steps. The methodology provides rapid access to thiazole-4-carbonitrile, thiazole-4-carbimidate, thiazole-oxazoline, and other thiazole-thiazoline derivatives that are important intermediates in the total synthesis of many natural products with important biological properties.
|Journal||Journal of Organic Chemistry|
|Publication status||Published - 2 Dec 2011|
- The Faculty of Pharmaceutical Sciences