Confirmatory analysis of survival data using left truncation of the life times of primary survivors

Research output: Contribution to journalJournal articleResearchpeer-review

  • Niels Keiding
  • Thomas Bayer
  • Steen Watt‐Boolsen

In survival analysis, as in other branches of applied statistics, confirmatory analysis is often requested before an initial finding can be cleared of suspicion of being due just to mass significance. This paper points out that the special temporal structure of the classical clinical trial with staggered entry allows re‐use of the initial survivors by left‐truncating their remaining survival times. This procedure can often save a considerable amount of calendar time. The procedure is illustrated by data from the Danish Breast Cancer Cooperative Group.

Original languageEnglish
JournalStatistics in Medicine
Volume6
Issue number8
Pages (from-to)939-944
Number of pages6
ISSN0277-6715
DOIs
Publication statusPublished - Dec 1987

    Research areas

  • Breast cancer, Censored observations, Confirmatory analysis, Data splitting, Interim analysis, Left truncation, Mass significance, Survival analysis

ID: 202336256