Do environmental estrogens contribute to the decline in male reproductive health?
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Do environmental estrogens contribute to the decline in male reproductive health? / Jensen, Tina Kold; Toppari, Jorma; Keiding, Niels; Skakkebæk, Niels Erik.
In: Clinical Chemistry, Vol. 41, No. 12, 12.1995, p. 1896-1901.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Do environmental estrogens contribute to the decline in male reproductive health?
AU - Jensen, Tina Kold
AU - Toppari, Jorma
AU - Keiding, Niels
AU - Skakkebæk, Niels Erik
PY - 1995/12
Y1 - 1995/12
N2 - Several observations suggest that male reproductive health has been declining since World War II in many countries. The incidence of testicular cancer, hypospadias, and cryptorchidism has been increasing and semen quality has been decreasing, and these may have a common etiology. Treatment of several million pregnant women with the synthetic estrogen diethylstilbestrol led to an increase in these conditions among the sons of these women. These abnormalities probably arise during fetal development. The similarity between these effects and the adverse change in male reproductive development and function raised the question of whether the adverse changes are attributable to altered exposures to estrogenic and other endocrine-disrupting agents during fetal development. We speculate that alteration in exposure to estrogen in the past half-century may have caused the changes in male reproductive health.
AB - Several observations suggest that male reproductive health has been declining since World War II in many countries. The incidence of testicular cancer, hypospadias, and cryptorchidism has been increasing and semen quality has been decreasing, and these may have a common etiology. Treatment of several million pregnant women with the synthetic estrogen diethylstilbestrol led to an increase in these conditions among the sons of these women. These abnormalities probably arise during fetal development. The similarity between these effects and the adverse change in male reproductive development and function raised the question of whether the adverse changes are attributable to altered exposures to estrogenic and other endocrine-disrupting agents during fetal development. We speculate that alteration in exposure to estrogen in the past half-century may have caused the changes in male reproductive health.
KW - cryptorchidism
KW - diethylstilbestrol
KW - hypospadias
KW - sperm count
KW - testicular cancer
UR - http://www.scopus.com/inward/record.url?scp=0028860636&partnerID=8YFLogxK
M3 - Journal article
C2 - 7497651
AN - SCOPUS:0028860636
VL - 41
SP - 1896
EP - 1901
JO - Clinical Chemistry
JF - Clinical Chemistry
SN - 0009-9147
IS - 12
ER -
ID: 201899057