Gitta Wörtwein
Associate Professor
Section of Environmental Health
Øster Farimagsgade 5, 1014 København K, 05 Øster Farimagsgade 5, Building: 05-1-08
Member of:
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Erythropoietin prevents the effect of chronic restraint stress on the number of hippocampal CA3c dendritic terminals-relation to expression of genes involved in synaptic plasticity, angiogenesis, inflammation, and oxidative stress in male rats
Aalling, Nadia, Hageman, Ida, Miskowiak, Kamilla, Orlowski, D., Wegener, G. & Wörtwein, Gitta, Jan 2018, In: Journal of Neuroscience Research. 96, 1, p. 103–116Research output: Contribution to journal › Journal article › Research › peer-review
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Effects of electroconvulsive seizures and antidepressant drugs on brain-derived neurotrophic factor protein in rat brain
Altar, C. A., Whitehead, R. E., Chen, R., Wörtwein, Gitta & Madsen, T. M., 2003, In: Biological Psychiatry. VOl. 54, no. 7, p. 703-9Research output: Contribution to journal › Journal article › Research › peer-review
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The circadian oscillator of the cerebral cortex: molecular, biochemical and behavioral effects of deleting the Arntl clock gene in cortical neurons
Bering, Tenna, Carstensen, M. B., Wörtwein, Gitta, Weikop, Pia & Rath, Martin Fredensborg, Feb 2018, In: Cerebral Cortex. 28, 2, p. 644–657Research output: Contribution to journal › Journal article › Research › peer-review
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Abeta(1-42) injection causes memory impairment, lowered cortical and serum BDNF levels, and decreased hippocampal 5-HT(2A) levels
Christensen, R., Marcussen, A. B., Wörtwein, Gitta, Knudsen, G. M. & Aznar, S., 2008, In: Experimental Neurology. 210, 1, p. 164-71 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Fluoxetine reverts chronic restraint stress-induced depression-like behaviour and increases neuropeptide Y and galanin expression in mice
Christiansen, S. H. O., Olesen, M. V., Wörtwein, Gitta & Woldbye, David Paul Drucker, 20 Jan 2011, In: Behavioural Brain Research. 216, 2, p. 585-91 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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INACTIVATION OF THE CHOLINERGIC M4 RECEPTOR RESULTS IN THE DEVELOPMENT OF A LOW ANXIETY ENDOPHENOTYPE PREDICTING FUTURE ALCOHOL CONSUMPTION
Dencker, D., Wörtwein, Gitta, Lysne, C., Weikop, Pia, Fink-Jensen, Anders & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i57-i58 2 p., P-49.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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SUBCHRONIC LOW DOSE EXENDIN-4 PRETREATMENT INHIBITS RELAPSE TO ALCOHOL DRINKING IN HIGH ALCOHOL PREFERING C57BL6 MICE
Dencker, D., Egecioglu, E., Jerlhag, E., Wörtwein, Gitta, Weikop, Pia, Fink-Jensen, Anders & Molander, A., 2015, In: Alcohol and Alcoholism. 50, suppl 1, p. i17-i18 2 p., SY15-2.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
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Ketogenic Diet suppresses Alcohol Withdrawal Syndrome in Rats
Dencker, D., Molander, A., Thomsen, M., Schlumberger, C., Wörtwein, Gitta, Weikop, P., Benveniste, H., Volkow, N. D. & Fink-Jensen, Anders, Feb 2018, In: Alcoholism: Clinical and Experimental Research. 42, 2, p. 270-277Research output: Contribution to journal › Journal article › Research › peer-review
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Involvement of a subpopulation of neuronal M4 muscarinic acetylcholine receptors in the antipsychotic-like effects of the M1/M4 preferring muscarinic receptor agonist xanomeline
Dencker, D., Wörtwein, Gitta, Weikop, Pia, Jeon, J., Thomsen, M., Sager, T. N., Mørk, A., Woldbye, David Paul Drucker, Wess, J. & Fink-Jensen, Anders, 2011, In: Journal of Neuroscience. 31, 16, p. 5905-8 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Muscarinic Acetylcholine Receptor Subtypes as Potential Drug Targets for the Treatment of Schizophrenia, Drug Abuse and Parkinson's Disease
Dencker, D., Thomsen, M., Wörtwein, Gitta, Weikop, Pia, Cui, Y., Jeon, J., Wess, J. & Fink-Jensen, Anders, 22 Nov 2011, In: ACS Chemical Neuroscience. 3, 2, p. 80-89 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Neuropeptide Y-stimulated [(35) S]GTPγs functional binding is reduced in the hippocampus after kainate-induced seizures in mice
Elbrønd-Bek, H., Olling, J. D., Gøtzsche, C. R., Waterfield, A., Wörtwein, Gitta & Woldbye, David Paul Drucker, 9 Jul 2014, In: Synapse. 68, 10, p. 427-36 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The impact of maternal separation on adult mouse behaviour and on the total neuron number in the mouse hippocampus
Fabricius, K., Wörtwein, Gitta & Pakkenberg, B., 2008, In: Brain Structure and Function (Print Edition). 212, 5, p. 403-416 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Socially isolated rats exhibit changes in dopamine homeostasis pertinent to schizophrenia
Fabricius, K., Steiniger-Brach, B., Helboe, L., Fink-Jensen, Anders & Wörtwein, Gitta, 2011, In: International Journal of Developmental Neuroscience. 29, 3, p. 347-50 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Pharmacological characterization of social isolation-induced hyperactivity
Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, Gitta & Steiniger-Brach, B., 2011, In: Psychopharmacology. 215, 2, p. 257-66 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Increased dopaminergic activity in socially isolated rats: an electrophysiological study
Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, Gitta, Steiniger-Brach, B., Sotty, F., Fabricius, K., Helboe, L., Fink-Jensen, Anders, Wörtwein, G., Steiniger-Brach, B. & Sotty, F., 27 Sep 2010, In: Neuroscience Letters. 482, 2, p. 117-22 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Role for M5 muscarinic acetylcholine receptors in cocaine addiction
Fink-Jensen, A., Fedorova, I., Wörtwein, Gitta, Woldbye, David Paul Drucker, Rasmussen, T., Thomsen, M., Bolwig, T. G., Knitowski, K. M., McKinzie, D. L., Yamada, M., Wess, J. & Basile, A., 2003, In: Journal of Neuroscience Research. 74, 1, p. 91-6Research output: Contribution to journal › Journal article › Research › peer-review
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Antipsychotic-induced catalepsy is attenuated in mice lacking the M4 muscarinic acetylcholine receptor.
Fink-Jensen, Anders, Schmidt, L. S., Dencker, D., Schülein, C., Wess, J., Wörtwein, Gitta & Woldbye, David Paul Drucker, 10 Apr 2011, In: European Journal of Pharmacology. 656, 1-3, p. 39-44 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Did Stress Prevalence Among Adolescents in Scandinavia Change from 2000 to 2019? A literature review
Flægstad, T. K., Åström, M., Baudocco, S. & Wörtwein, Gitta, 2023, In: Scandinavian Journal of Child and Adolescent Psychiatry and Psychology. 11, 1, p. 150-162 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Dynamic regulation of cerebral DNA repair genes by psychological stress
Forsberg, K., Aalling, Nadia, Wörtwein, Gitta, Loft, Steffen, Møller, Peter, Hau, Jann, Hageman, I., Jørgensen, M. B. & Jørgensen, Anders, 15 Jan 2015, In: Mutation Research - Genetic Toxicology and Environmental Mutagenesis. 778, p. 37-43 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Expression of erythropoietin receptor protein in the mouse hippocampus in response to normobaric hypoxia
Fussing, F., Christensson, J. & Wörtwein, Gitta, 2024, In: Heliyon. 10, 3, 8 p., e25051.Research output: Contribution to journal › Journal article › Research › peer-review
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Delayed restraint procedure enhances cognitive recovery of spatial function after fimbria-fornix transection
Gram, M. G., Wogensen, E., Wörtwein, Gitta, Mogensen, J. & Rytter, Hana Malá, 2015, In: Restorative Neurology and Neuroscience. 34, 1, p. 1-17Research output: Contribution to journal › Journal article › Research › peer-review
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Maternal separation affects male rat copulatory behaviour and hypothalamic corticotropin releasing factor in concert
Greisen, M. H., Bolwig, T. G., Husum, H., Nedergaard, P. & Wörtwein, Gitta, 2005, In: Behavioural Brain Research. 158(2), p. 367-375Research output: Contribution to journal › Journal article › Research › peer-review
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Increased adult hippocampal brain-derived neurotrophic factor and normal levels of neurogenesis in maternal separation rats
Greisen, M. H., Altar, C. A., Bolwig, T. G., Whitehead, R. E. & Wörtwein, Gitta, 2005, In: Journal of Neuroscience Research. 79/6, p. 772-778Research output: Contribution to journal › Journal article › Research › peer-review
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Cholecystokinin tetrapeptide effects on HPA axis function and elevated plus maze behaviour in maternally separated and handled rats
Greisen, M. H., Bolwig, T. G. & Wörtwein, Gitta, 2005, In: Behavioural Brain Research. Vol 161, p. 204-12Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive stimulations prevent stress-induced morphological changes in the hippocampus
Hageman, I., Nielsen, M., Wörtwein, Gitta, Diemer, N. H. & Jorgensen, M. B., 2008, In: Stress: The International Journal on the Biology of Stress . 11, 4, p. 282-9 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive stimulations normalizes stress-induced changes in the glucocorticoid receptor and behaviour
Hageman, Ida, Nielsen, M., Wörtwein, Gitta, Diemer, N. H. & Jorgensen, M. B., 2009, In: Behavioural Brain Research. 196, 1, p. 71-7 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Time course and duration of changes in Kv7.2 and Kv11.1 mRNA expression in the hippocampus and piriform cortex following electroconvulsive stimulations
Hjaeresen, M., Hageman, I., Wörtwein, Gitta & Jørgensen, Martin Balslev, 2012, In: Brain Stimulation. 5, 1, p. 55-60 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chronic electroconvulsive stimulation but not chronic restraint stress modulates mRNA expression of voltage-dependent potassium channels Kv7.2 and Kv11.1 in the rat piriform cortex.
Hjæresen, M., Hageman, Ida, Wörtwein, Gitta, Plenge, P., Jørgensen, Martin Balslev & Wörtwein, Gitta, 2008, In: Brain Research. 1217C, p. 179-184 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Exacerbated loss of cell survival, neuropeptide Y-immunoreactive (IR) cells, and serotonin-IR fiber lengths in the dorsal hippocampus of the aged flinders sensitive line "depressed" rat: Implications for the pathophysiology of depression?
Husum, H., Aznar, S., Hoyer-Hansen, S., Larsen, M. H., Mikkelsen, J. D., Moller, A., Mathe, A. A. & Wörtwein, Gitta, 2006, In: Journal of Neuroscience Research. 84, 6, p. 1292-1302 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Gene-environment interaction affects substance P and neurokinin A in the entorhinal cortex and periaqueductal grey in a genetic animal model of depression: implications for the pathophysiology of depression
Husum, H., Wörtwein, Gitta, Andersson, W., Bolwig, T. G. & Mathé, A. A., 2008, In: International Journal of Neuropsychopharmacology. 11, 1, p. 93-101 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis
Jensen, Kathrine Louise, Sørensen, G., Dencker, D., Owens, W. A., Rahbek-Clemmensen, T., Brett Lever, M., Runegaard, A. H., Riis Christensen, N., Weikop, Pia, Wörtwein, Gitta, Fink-Jensen, Anders, Madsen, Kenneth Lindegaard, Daws, L., Gether, Ulrik & Rickhag, Karl Mattias, 2018, In: eNeuro. 5, 3Research output: Contribution to journal › Journal article › Research › peer-review
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A subpopulation of neuronal M4 muscarinic acetylcholine receptors plays a critical role in modulating dopamine-dependent behaviors
Jeon, J., Dencker, D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A., Levey, A. I., Schütz, G., Sager, T. N., Mørk, A., Li, C., Deng, C-X., Fink-Jensen, A., Wess, J., Jeon, J., Nielsen, D. D., Wörtwein, G., Woldbye, D. P. D., Cui, Y., Davis, A. A. & 8 others, , 10 Feb 2010, In: Journal of Neuroscience. 30, 6, p. 2396-405 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Chronic restraint stress in rats causes sustained increase in urinary corticosterone excretion without affecting cerebral or systemic oxidatively generated DNA/RNA damage
Jorgensen, A., Maigaard, K., Wörtwein, Gitta, Hageman, I., Henriksen, T., Weimann, A., Møller, Peter, Loft, Steffen, Hau, Jann, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, 10 Jan 2013, In: Progress in Neuro-Psychopharmacology & Biological Psychiatry. 40, p. 30-37Research output: Contribution to journal › Journal article › Research › peer-review
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A chronic increase of corticosterone age-dependently reduces systemic DNA damage from oxidation in rats
Jørgensen, Anders, Kalliokoski, Otto, Forsberg, K., Breitenstein, K., Weimann, A., Henriksen, T., Hau, Jann, Wörtwein, Gitta, Poulsen, Henrik Enghusen & Jørgensen, Martin Balslev, Mar 2017, In: Free Radical Biology & Medicine. 104, p. 64-74 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Markers of HPA-axis activity and nucleic acid damage from oxidation after electroconvulsive stimulations in rats
Jørgensen, Anders, Breitenstein, K., Kalliokoski, Otto, Weimann, A., Henriksen, T., Poulsen, Henrik Enghusen, Jørgensen, Martin Balslev & Wörtwein, Gitta, 2019, In: Acta Neuropsychiatrica. 31, 6, p. 287-293 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
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The effect of erythropoietin on electroconvulsive stimulation induced cognitive impairment in rats
Kjær, K., Jørgensen, Martin Balslev, Hageman, Ida, Miskowiak, Kamilla & Wörtwein, Gitta, 2020, In: Behavioural Brain Research. 382, 112484.Research output: Contribution to journal › Journal article › Research › peer-review
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Erytropoietin behandling kan forbedre kognition ved neuropsykiatriske lidelser
Kjær, K. S., Hageman, Ida, Wörtwein, Gitta, Jørgensen, Martin Balslev & Miskowiak, Kamilla, 14 Aug 2017, In: Ugeskrift for Laeger. 179, 22, p. 2-6 5 p., V01170037.Research output: Contribution to journal › Journal article › Research › peer-review
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The role of glucagon-like peptide 1 (GLP-1) in addictive disorders
Kruse Klausen, M., Thomsen, Morgane, Wörtwein, Gitta & Fink-Jensen, Anders, 2022, In: British Journal of Pharmacology. 179, 4, p. 625-641 17 p.Research output: Contribution to journal › Review › Research › peer-review
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Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat
Madsen, T. M., Kristjansen, P. E. G., Bolwig, T. G. & Wörtwein, Gitta, 2003, In: Neuroscience. Vol. 119, p. 635-42Research output: Contribution to journal › Journal article › Research › peer-review
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Electroconvulsive stimulations prevent chronic stress-induced increases in L-type calcium channel mRNAs in the hippocampus and basolateral amygdala
Maigaard, K., Hageman, Ida, Jørgensen, A., Jørgensen, Martin Balslev & Wörtwein, Gitta, 2012, In: Neuroscience Letters. 516, 1, p. 24-8 5 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Adult Brain and Behavioral Effect of Early Life Maternal Deprivation
Mathe, A. A., El Khoury, A., Gruber, S. H. M., Husum, H., Wörtwein, Gitta & Arlinde, C., 2009, Beyond neuropsychiatric diagnostics: Symptoms not disorders. Palomo, T., Beninger, R. J., Kostzewa, R. M. & Archer, T. (eds.). Mountain Home, TN, USA: F. P. Graham Publishing Co.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Research
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Increased numbers of orexin/hypocretin neurons in a genetic rat depression model
Mikrouli, E., Wörtwein, Gitta, Soylu, R., Mathé, A. A. & Petersén, Å., 2011, In: Neuropeptides (Sheffield). 45, 6, p. 401-6 6 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Proinflammatory biomarkers are associated with prediabetes in patients with schizophrenia
Mller, M., Fredholm, S., Jensen, M. E., Wörtwein, Gitta, Larsen, J. R., Vilsbøll, Tina, Ødum, Niels & Fink-Jensen, Anders, 2022, In: CNS Spectrums. 27, 3, 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
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Place learning and object recognition by rats subjected to transection of the fimbria-fornix and/or ablation of the prefrontal cortex
Mogensen, J., Lauritsen, K. T., Elvertorp, S., Hasman, A., Moustgaard, A. & Wörtwein, Gitta, 2004, In: Brain Research Bulletin. Vol. 63, no. 3, p. 217-36Research output: Contribution to journal › Journal article › Research › peer-review
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Place learning in scolopamine-treated rats: the role of distal cues and catecholaminergic mediation
Mogensen, J., Christensen, L. H., Johansson, A., Wörtwein, Gitta, Bang, L. E. & Holm, S., 2002, In: Neurobiology of Learning and Memory. 78(1), p. 139-66Research output: Contribution to journal › Journal article › Research › peer-review
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Associative an nonassociative learning after chronic imipramine in rats
Mogensen, J., Svendsen, G., Tølbøll Lauritsen, K., Ermens, P., Hasman, A., Elvertorp, S., Plenge, P. K., Mellerup, Erling Thyge & Wörtwein, Gitta, 2003, In: Pharmacology, Biochemistry and Behavior. Vol. 76, p. 197-212Research output: Contribution to journal › Journal article › Research › peer-review
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Place learning during inhibition of nitric oxide synthase in the rat
Mogensen, J., Hasman, A. & Wörtwein, Gitta, 1995, In: Homeostasis. 36, p. 12-18Research output: Contribution to journal › Journal article › Research › peer-review
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L-Nitroarginine reduces hippocampal mediation of place learning in the rat
Mogensen, J., Wörtwein, Gitta, Gustafson, B. & Ermens, P., 1995, In: Neurobiology of Learning and Memory. 64, p. 17-24Research output: Contribution to journal › Journal article › Research › peer-review
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Analysis of response patterns during prefrontally ablated rats acquisition of an egocentric spatial task in an 8-arm radialmaze
Mogensen, J., Montero, A. & Wörtwein, Gitta, 2003, In: Homeostasis. Vol. 42, no.1-2, p. 52-59Research output: Contribution to journal › Journal article › Research › peer-review
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Egocentric spatial orientation in a water maze by rats subjected to transection of the fimbria-fornix and/or ablation of the prefrontal cortex
Mogensen, J., Moustgaard, A., Khan, U., Wörtwein, Gitta & Sandager Nielsen, K., 2005, In: Brain Research Bulletin. 65, 1, p. 41-58Research output: Contribution to journal › Journal article › Research › peer-review
ID: 12474
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Locomotor- and Reward-Enhancing Effects of Cocaine Are Differentially Regulated by Chemogenetic Stimulation of Gi-Signaling in Dopaminergic Neurons
Research output: Contribution to journal › Journal article › Research › peer-review
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151
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PICK1-Deficient Mice Exhibit Impaired Response to Cocaine and Dysregulated Dopamine Homeostasis
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
139
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Glucagon-like peptide 1 receptor activation regulates cocaine actions and dopamine homeostasis in the lateral septum by decreasing arachidonic acid levels
Research output: Contribution to journal › Journal article › Research › peer-review
Published