Martin Roursgaard
Associate Professor
Section of Environmental Health
Øster Farimagsgade 5
1353 København K
Primary fields of research
My primary focus is the toxicological effects of exposure to environmental factors. The research focuses is on mechanisms of action of environmental agents, using cell cultures, experimental laboratory models and controlled human exposures. The outcome aim to develop better models for understadning of the following:
- Molecular and functional assessment of exposure, susceptibility and effects
- Experimental in vitro and in vivo model systems
- Alternatives to animal experimentation
Current research
Use of in vitro models to investigate cell-cell interactions as well as cell exposure interactions. The primary use of the cell models are investigation of the effect of exposure to different types of particle such as air pollution and combustion particles as well as micro- and nanoplastic particles. Major focus is on cellular effects such as oxidative stress, inflammation and DNA damage.
Key word
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Particle toxicology
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Nanoparticles
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Nanoplastic
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Mikroplastic
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Nanomedicine
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co-cultures
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Oxidativ stress
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DNA damage
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Cell-cell interaction
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Cell-particle interaction
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Pulmonary effects
- Cardiovascular effects
Possible conflicts of interest
No conflicts of interest
Selected publications
- Published
Effects of alcohol consumption on the allergen-specific immune response in mice
Linneberg, Allan René, Roursgaard, Martin, Hersoug, L. & Larsen, S. T., 2008, In: Alcoholism: Clinical and Experimental Research. 32, 3, p. 553-557 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells
Frikke-Schmidt, H. R., Roursgaard, Martin, Lykkesfeldt, Jens, Loft, Steffen, Nøjgaard, J. K. & Møller, Peter, 2011, In: Toxicology Letters. 203, 3, p. 181-189 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidative stress, genotoxicity, and vascular cell adhesion molecule expression in cells exposed to particulate matter from combustion of conventional diesel and methyl ester biodiesel blends
Hemmingsen, J. G., Møller, Peter, Nøjgaard, J. K., Roursgaard, Martin & Loft, Steffen, 1 Oct 2011, In: Environmental Science & Technology (Washington). 45, 19, p. 8545-51 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA
Loft, Steffen, Danielsen, P. H., Løhr, M., Jantzen, K., Hemmingsen, J. G., Roursgaard, Martin, Karottki, D. G. & Møller, Peter, 2012, In: Archives of Biochemistry and Biophysics. 518, 2, p. 142-50 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Transport of SiO(2) Nanoparticles through Human Skin
Staronová, K., Nielsen, J. B., Roursgaard, Martin & Knudsen, Lisbeth E., 2012, In: Basic & Clinical Pharmacology & Toxicology Online. 111, 2, p. 142-4 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Expression of adhesion molecules, monocyte interactions and oxidative stress in human endothelial cells exposed to wood smoke and diesel exhaust particulate matter
Forchhammer, L., Loft, Steffen, Roursgaard, Martin, Cao, Y., Riddervold, I. S., Sigsgaard, T. & Møller, Peter, 2012, In: Toxicology Letters. 209, 2, p. 121-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Carbon black nanoparticles and vascular dysfunction in cultured endothelial cells and artery segments
Vesterdal, L. K., Mikkelsen, L., Folkmann, J. K., Sheykhzade, Majid, Cao, Y., Roursgaard, Martin, Loft, Steffen & Møller, Peter, 2012, In: Toxicology Letters. 214, 1, p. 19-26 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages
Jantzen, K., Roursgaard, Martin, Desler, Claus, Loft, Steffen, Rasmussen, Lene Juel & Møller, Peter, Nov 2012, In: Mutagenesis. 27, 6, p. 693-701 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice
Vesterdal, L. K., Jantzen, K., Sheykhzade, Majid, Roursgaard, Martin, Folkmann, J. K., Loft, Steffen & Møller, Peter, 14 Nov 2012, In: Nanotoxicology. 8, 1, p. 61-71Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Oxidatively damaged DNA in animals exposed to particles
Møller, Peter, Danielsen, P. H., Jantzen, K., Roursgaard, Martin & Loft, Steffen, Feb 2013, In: Critical Reviews in Toxicology. 43, 2, p. 96-118 23 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Hazard identification of particulate matter on vasomotor dysfunction and progression of atherosclerosis
Møller, Peter, Mikkelsen, L., Vesterdal, L. K., Folkmann, J. K., Forchhammer, L., Roursgaard, Martin, Danielsen, P. H. & Loft, Steffen, 1 Apr 2011, In: Critical Reviews in Toxicology. 41, 4, p. 339-68 30 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Acute and subchronic airway inflammation after intratracheal instillation of quartz and titanium dioxide agglomerates in mice
Roursgaard, Martin, Jensen, K. A., Poulsen, Steen Seier, Jensen, N. E. V., Poulsen, Lars K., Hammer, M., Nielsen, G. D. & Larsen, S. T., 1 Jan 2011, In: Scientific World Journal. 11, p. 801-25 25 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Time-response relationship of nano and micro particle induced lung inflammation. Quartz as reference compound
Roursgaard, Martin, Poulsen, Steen Seier, Poulsen, Lars K., Hammer, M., Jensen, K. A., Utsunomiya, S., Ewing, R. C., Balic Zunic, Tonci, Nielsen, G. D. & Larsen, S. T., 2010, In: Human & Experimental Toxicology. 29, 11, p. 915-933 19 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells
Eriksen, K. T., Raaschou-Nielsen, O., Sørensen, M., Roursgaard, Martin, Loft, Steffen & Møller, Peter, 2010, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 700, 1-2, p. 39-43 4 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Polyhydroxylated C60 fullerene (fullerenol) attenuates neutrophilic lung inflammation in mice
Roursgaard, Martin, Poulsen, Steen Seier, Kepley, C. L., Hammer, M., Nielsen, G. D. & Larsen, S. T., 1 Oct 2008, In: Basic & Clinical Pharmacology & Toxicology Online. 103, 4, p. 386-8 3 p.Research output: Contribution to journal › Journal article › Research › peer-review
ID: 14356010
Most downloads
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204
downloads
Hepatic toxicity assessment of cationic liposome exposure in healthy and chronic alcohol fed mice
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
141
downloads
Vasomotor function in rat arteries after ex vivo and intragastric exposure to food-grade titanium dioxide and vegetable carbon particles
Research output: Contribution to journal › Journal article › Research › peer-review
Published -
131
downloads
Health effects of exposure to diesel exhaust in diesel-powered trains
Research output: Contribution to journal › Journal article › Research › peer-review
Published