Martin Roursgaard

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Primary fields of research

My primary focus is the toxicological effects of exposure to environmental factors. The research focuses is on mechanisms of action of environmental agents, using cell cultures,  experimental laboratory models and controlled human exposures. The outcome aim to develop better models for understadning of the following: 

• Molecular and functional assessment of exposure, susceptibility and effects
• Experimental in vitro and in vivo model systems
• Alternatives to animal experimentation

Current research

Use of in vitro models to investigate cell-cell interactions as well as cell exposure interactions. The primary use of the cell models are investigation of the effect of exposure to different types of particle  such as air pollution and combustion particles as well as micro- and nanoplastic particles. Major focus is on cellular effects such as oxidative stress, inflammation and DNA damage. 

Key word

• Particle toxicology

• Nanoparticles

• Nanoplastic

• Mikroplastic 

• Nanomedicine

• co-cultures

• Oxidativ stress

• DNA damage 

• Cell-cell interaction

• Cell-particle interaction

• Pulmonary effects

• Cardiovascular effects

Possible conflicts of interest

No conflicts of interest 

Selected publications

1. Published

   Effects of alcohol consumption on the allergen-specific immune response in mice

   Linneberg, Allan René, Roursgaard, Martin, Hersoug, L. & Larsen, S. T., 2008, In: Alcoholism: Clinical and Experimental Research. 32, 3, p. 553-557 4 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

2. Published

   Effect of vitamin C and iron chelation on diesel exhaust particle and carbon black induced oxidative damage and cell adhesion molecule expression in human endothelial cells

   Frikke-Schmidt, H. R., Roursgaard, Martin, Lykkesfeldt, Jens, Loft, Steffen, Nøjgaard, J. K. & Møller, Peter, 2011, In: Toxicology Letters. 203, 3, p. 181-189 9 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

3. Published

   Oxidative stress, genotoxicity, and vascular cell adhesion molecule expression in cells exposed to particulate matter from combustion of conventional diesel and methyl ester biodiesel blends

   Hemmingsen, J. G., Møller, Peter, Nøjgaard, J. K., Roursgaard, Martin & Loft, Steffen, 1 Oct 2011, In: Environmental Science & Technology (Washington). 45, 19, p. 8545-51 7 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

4. Published

   Urinary excretion of 8-oxo-7,8-dihydroguanine as biomarker of oxidative damage to DNA

   Loft, Steffen, Danielsen, P. H., Løhr, M., Jantzen, K., Hemmingsen, J. G., Roursgaard, Martin, Karottki, D. G. & Møller, Peter, 2012, In: Archives of Biochemistry and Biophysics. 518, 2, p. 142-50 9 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

5. Published

   Transport of SiO(2) Nanoparticles through Human Skin

   Staronová, K., Nielsen, J. B., Roursgaard, Martin & Knudsen, Lisbeth E., 2012, In: Basic & Clinical Pharmacology & Toxicology Online. 111, 2, p. 142-4 3 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

6. Published

   Expression of adhesion molecules, monocyte interactions and oxidative stress in human endothelial cells exposed to wood smoke and diesel exhaust particulate matter

   Forchhammer, L., Loft, Steffen, Roursgaard, Martin, Cao, Y., Riddervold, I. S., Sigsgaard, T. & Møller, Peter, 2012, In: Toxicology Letters. 209, 2, p. 121-8 8 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

7. Published

   Carbon black nanoparticles and vascular dysfunction in cultured endothelial cells and artery segments

   Vesterdal, L. K., Mikkelsen, L., Folkmann, J. K., Sheykhzade, Majid, Cao, Y., Roursgaard, Martin, Loft, Steffen & Møller, Peter, 2012, In: Toxicology Letters. 214, 1, p. 19-26 8 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

8. Published

   Oxidative damage to DNA by diesel exhaust particle exposure in co-cultures of human lung epithelial cells and macrophages

   Jantzen, K., Roursgaard, Martin, Desler, Claus, Loft, Steffen, Rasmussen, Lene Juel & Møller, Peter, Nov 2012, In: Mutagenesis. 27, 6, p. 693-701 9 p.

   Research output: Contribution to journal › Journal article › Research › peer-review

9. Published

   Pulmonary exposure to particles from diesel exhaust, urban dust or single-walled carbon nanotubes and oxidatively damaged DNA and vascular function in apoE(-/-)mice

   Vesterdal, L. K., Jantzen, K., Sheykhzade, Majid, Roursgaard, Martin, Folkmann, J. K., Loft, Steffen & Møller, Peter, 14 Nov 2012, In: Nanotoxicology. 8, 1, p. 61-71

   Research output: Contribution to journal › Journal article › Research › peer-review

10. Published

    Oxidatively damaged DNA in animals exposed to particles

    Møller, Peter, Danielsen, P. H., Jantzen, K., Roursgaard, Martin & Loft, Steffen, Feb 2013, In: Critical Reviews in Toxicology. 43, 2, p. 96-118 23 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

11. Published

    Hazard identification of particulate matter on vasomotor dysfunction and progression of atherosclerosis

    Møller, Peter, Mikkelsen, L., Vesterdal, L. K., Folkmann, J. K., Forchhammer, L., Roursgaard, Martin, Danielsen, P. H. & Loft, Steffen, 1 Apr 2011, In: Critical Reviews in Toxicology. 41, 4, p. 339-68 30 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

12. Published

    Acute and subchronic airway inflammation after intratracheal instillation of quartz and titanium dioxide agglomerates in mice

    Roursgaard, Martin, Jensen, K. A., Poulsen, Steen Seier, Jensen, N. E. V., Poulsen, Lars K., Hammer, M., Nielsen, G. D. & Larsen, S. T., 1 Jan 2011, In: Scientific World Journal. 11, p. 801-25 25 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

13. Published

    Time-response relationship of nano and micro particle induced lung inflammation. Quartz as reference compound

    Roursgaard, Martin, Poulsen, Steen Seier, Poulsen, Lars K., Hammer, M., Jensen, K. A., Utsunomiya, S., Ewing, R. C., Balic Zunic, Tonci, Nielsen, G. D. & Larsen, S. T., 2010, In: Human & Experimental Toxicology. 29, 11, p. 915-933 19 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

14. Published

    Genotoxic potential of the perfluorinated chemicals PFOA, PFOS, PFBS, PFNA and PFHxA in human HepG2 cells

    Eriksen, K. T., Raaschou-Nielsen, O., Sørensen, M., Roursgaard, Martin, Loft, Steffen & Møller, Peter, 2010, In: Mutation Research - Fundamental and Molecular Mechanisms of Mutagenesis. 700, 1-2, p. 39-43 4 p.

    Research output: Contribution to journal › Journal article › Research › peer-review

15. Published

    Polyhydroxylated C60 fullerene (fullerenol) attenuates neutrophilic lung inflammation in mice

    Roursgaard, Martin, Poulsen, Steen Seier, Kepley, C. L., Hammer, M., Nielsen, G. D. & Larsen, S. T., 1 Oct 2008, In: Basic & Clinical Pharmacology & Toxicology Online. 103, 4, p. 386-8 3 p.

    Research output: Contribution to journal › Journal article › Research › peer-review