Mogens Grønvold
Professor
Section of Health Services Research
Øster Farimagsgade 5 opg. B
1353 København K
- 2021
- Published
Effectiveness of a nurse-delivered (FOCUS plus ) and a web-based (iFOCUS) psychoeducational intervention for people with advanced cancer and their family caregivers (DIAdIC): study protocol for an international randomized controlled trial
Matthys, O., De Vleminck, A., Dierickx, S., Deliens, L., Van Goethem, V., Lapeire, L., Grønvold, M., Lund, L., Arnfeldt, C. M., Sengeløv, L., Pappot, H., Johnsen, A. T., Guerin, S., Larkin, P. J., Jordan, C., Connolly, M., D'Alton, P., Costantini, M., Di Leo, S., Guberti, M. & 17 others, , 2021, In: BMC Palliative Care. 20, 1, 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Establishing anchor-based minimally important differences for the EORTC QLQ-C30 in glioma patients
Dirven, L., Musoro, J. Z., Coens, C., Reijneveld, J. C., Taphoorn, M. J. B., Boele, F. W., Grønvold, Mogens, van den Bent, M. J., Stupp, R., Velikova, G., Cocks, K., Sprangers, M. A. G., King, M. T., Flechtner, H. & Bottomley, A., 2021, In: Neuro-Oncology. 23, 8, p. 1327–1336 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Evaluating the Thresholds for Clinical Importance of the EORTC QLQ-C15-PAL in Patients Receiving Palliative Treatment
Pilz, M. J., Aaronson, N. K., Arraras, J. I., Caocci, G., Efficace, F., Grønvold, Mogens, Holzner, B., van Leeuwen, M., Loth, F. L. C., Petersen, M. A., Ramage, J., Tomaszewski, K. A., Young, T. & Giesinger, J. M., 2021, In: Journal of Palliative Medicine. 24, 3, 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Functional impairment, symptom severity, and overall quality of life in patients with advanced lung or colorectal cancer in six European countries: baseline findings from the ACTION study
Verkissen, M. N., De Vleminck, A., Grønvold, Mogens, Jabbarian, L. J., Bulli, F., Cools, W., van Delden, J. J. M., Lunder, U., Miccinesi, G., Payne, S. A., Pollock, K., Rietjens, J. A. C. & Deliens, L., 2021, In: Supportive Care in Cancer. 29, p. 5797–5810 14 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Investigating the response scale of the EORTC QLQ-C30 in German cancer patients and a population survey
Koller, M., Müller, K., Nolte, S., Schmidt, H., Harvey, C., Mölle, U., Boehm, A., Engeler, D., Metzger, J., Sztankay, M., Holzner, B., Grønvold, Mogens, Kuliś, D., Bottomley, A. & EORTC Quality of Life Group, E. Q. O. L. G., 2021, In: Health and Quality of Life Outcomes. 19, 1, 14 p., 235.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Minimally important differences for the EORTC QLQ-C30 in prostate cancer clinical trials
Gamper, E. M., Musoro, J. Z., Coens, C., Stelmes, J., Falato, C., Grønvold, Mogens, Velikova, G., Cocks, K., Flechtner, H., King, M. T., Bottomley, A. & EORTC Genito-Urinary Tract Cancer Group and Quality of Life Groups, E. G. T. C. G. A. Q. O. L. G., 2021, In: BMC Cancer. 21, 1, 8 p., 1083.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Missing not at random in end of life care studies: multiple imputation and sensitivity analysis on data from the ACTION study
Carreras, G., Miccinesi, G., Wilcock, A., Preston, N., Nieboer, D., Deliens, L., Grønvold, Mogens, Lunder, U., van der Heide, A. & Baccini, M., 2021, In: BMC Medical Research Methodology. 21, 1, 12 p., 13.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Regional and age differences in specialised palliative care for patients with pancreatic cancer
Adsersen, M., Chen, I. M., Rasmussen, L. S., Johansen, Julia Sidenius, Nissen, M., Grønvold, Mogens & Marsaa, K., 2021, In: BMC Palliative Care. 20, 1, 9 p., 192.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Size and composition of family networks of decedents: A nationwide register-based study
Kristensen, M. S., Thygesen, L. C., Tay, D. L., Kumar, R., Grønvold, Mogens, Aldridge, M. & Ornstein, K. A., 2021, In: Palliative Medicine. 35, 9, p. 1652-1662 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Spørgeskemaundersøgelser
Grønvold, Mogens, 2021, Forskningsmetoder i Folkesundhedsvidenskab. Jensen, A. M. B. & Vallgårda, S. (eds.). 6 ed. København: Munksgaard , p. 272-302 31 p.Research output: Chapter in Book/Report/Conference proceeding › Book chapter › Communication
- 2020
- Published
Dansk Palliativ Database: Årsrapport 2019
Hansen, M. B., Adsersen, M. & Grønvold, Mogens, Jun 2020, København: DMCG-PAL. 71 p.Research output: Book/Report › Report › Communication
- Published
Reply to: Olanzapine: Sancho Panza for clinicians who care for patients with advanced cancer
Harder, S., Grønvold, Mogens & Herrstedt, Jørn, Apr 2020, In: Supportive Care in Cancer. 28, 4, p. 1539 1 p.Research output: Contribution to journal › Journal article › Research
- Published
International standards for the analysis of quality-of-life and patient-reported outcome endpoints in cancer randomised controlled trials: recommendations of the SISAQOL Consortium
Coens, C., Pe, M., Dueck, A. C., Sloan, J., Basch, E., Calvert, M., Campbell, A., Cleeland, C., Cocks, K., Collette, L., Devlin, N., Dorme, L., Flechtner, H-H., Gotay, C., Griebsch, I., Groenvold, M., King, M., Kluetz, P. G., Koller, M., Malone, D. C. & 16 others, , Feb 2020, In: Lancet Oncology. 21, 2, p. e83-e96 14 p.Research output: Contribution to journal › Review › Research › peer-review
- Published
Advance care planning in patients with advanced cancer: A 6-country, cluster-randomised clinical trial
Korfage, I. J., Carreras, G., Arnfeldt Christensen, C. M., Billekens, P., Bramley, L., Briggs, L., Bulli, F., Caswell, G., Červ, B., van Delden, J. J. M., Deliens, L., Dunleavy, L., Eecloo, K., Gorini, G., Groenvold, M., Hammes, B., Ingravallo, F., Jabbarian, L. J., Kars, M. C., Kodba-Čeh, H. & 17 others, , 2020, In: PLoS Medicine. 17, 11, 16 p., e1003422.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Advance care planning in patients with advanced cancer: results from the European 6 country, cluster-randomized ACTION trial
Korfage, I., Miccinesi, G., van Delden, J., Deliens, L., Grønvold, Mogens, Lunder, U., Payne, S., Pollock, K., van der Heide, A. & Rietjens, J., 2020, p. S64. 1 p.Research output: Contribution to conference › Conference abstract for conference › Research › peer-review
- Published
Clinical research in cancer palliative care: a metaresearch analysis
Vinches, M., Neven, A., Fenwarth, L., Terada, M., Rossi, G., Kelly, S., Peron, J., Thomaso, M., Grønvold, Mogens & De Rojas, T., 2020, In: BMJ Supportive & Palliative Care. 10, 2, p. 249-258 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Content analysis of Advance Directives completed by patients with advanced cancer as part of an Advance Care Planning intervention: insights gained from the ACTION trial
Zwakman, M., van Delden, J. J. M., Caswell, G., Deliens, L., Ingravallo, F., Jabbarian, L. J., Johnsen, A. T., Korfage, I. J., Mimic, A., Arnfeldt, C. M., Preston, N., Kars, M. C., van der Heide, A., Korfage, I. J., Rietjens, J. A. C., Jabbarian, L. J., Polinder, S., Billekens, P. F. A., van Delden, J. J. M., Kars, M. C. & 29 others, , 2020, In: Supportive Care in Cancer. 28, 3, p. 1513-1522Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Content validation of the EORTC QLQ-C15-PAL with advanced cancer patients and health care professionals from palliative care services in Chile
Rojas-Concha, L., Hansen, M. B., Petersen, M. A. & Grønvold, Mogens, 2020, In: BMC Palliative Care. 19, 1, 10 p., 81.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Development and content validation of a questionnaire measuring patient empowerment in cancer follow-up
Eskildsen, N. B., Ross, L., Bulsara, C., Dietz, S. M., Thomsen, T. G., Grønvold, Mogens, Pedersen, S. S., Jørgensen, C. R. & Johnsen, A. T., 2020, In: Quality of Life Research. 29, p. 2253-2274Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Ecological momentary assessments (EMAs) did not improve responsiveness of patient-reported outcomes on quality of life
Boesen, V. B., Bjørner, Jakob Bue, Grønvold, Mogens, Cramon, P. K., Rasmussen, A. K., Watt, Torquil & Feldt-Rasmussen, Ulla, 2020, In: Journal of Clinical Epidemiology. 125, p. 138-147 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Exploratory analyses of the Danish Palliative Care Trial (DanPaCT): a randomized trial of early specialized palliative care plus standard care versus standard care in advanced cancer patients
Johnsen, A. T., Petersen, M. A., Sjøgren, P., Pedersen, L., Neergaard, M. A., Damkier, A., Gluud, C., Fayers, P., Lindschou, J., Strömgren, A. S., Nielsen, J. B., Higginson, I. J. & Grønvold, Mogens, 2020, In: Supportive Care in Cancer. 28, p. 2145–2155 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Improving information to caregivers of cancer patients: the Herlev Hospital Empowerment of Relatives through More and Earlier information Supply (HERMES) randomized controlled trial
Lund, Line, Ross, L., Petersen, M. A., Sengeløv, L. & Grønvold, Mogens, 2020, In: Supportive Care in Cancer. 28, p. 939-950 12 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Integration af specialiseret palliation og onkologi
Sørensen, J., Neergaard, M. A., Grønvold, Mogens, Jensen, A. B., Sjøgren, P., Marsaa, K. & Kurita, G. P., 2020, In: Ugeskrift for Laeger. 182, 18, 10 p., V06190343.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
International validation of the EORTC CAT Core: a new adaptive instrument for measuring core quality of life domains in cancer
Petersen, Morten, Aaronson, N. K., Conroy, T., Costantini, A., Giesinger, J. M., Hammerlid, E., Holzner, B., Johnson, C. D., Kieffer, J. M., van Leeuwen, M., Nolte, S., Ramage, J. K., Tomaszewski, K. A., Waldmann, A., Young, T., Zotti, P. & Grønvold, Mogens, 2020, In: Quality of Life Research. 29, 5, p. 1405-1417 13 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Methylphenidate as Needed for Fatigue in Patients With Advanced Cancer: A Prospective, Double-Blind, and Placebo-Controlled Study
Pedersen, L., Lund, Line, Petersen, M. A., Sjøgren, P. & Grønvold, Mogens, 2020, In: Journal of Pain and Symptom Management. 60, 5, p. 992-1002 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer (EORTC) Quality of life Questionnaire core 30 scores in patients with ovarian cancer
Musoro, J. Z., Coens, C., Greimel, E., King, M. T., Sprangers, M. A. G., Nordin, A., van Dorst, E. B. L., Grønvold, Mogens, Cocks, K., Velikova, G., Flechtner, H. H., Bottomley, A. & on behalf of the EORTC Gynecological and Quality of Life Groups, O. B. O. T. E. G. A. Q. O. L. G., 2020, In: Gynecologic Oncology. 159, 2, p. 515-521 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Minimally important differences for interpreting European Organisation for Research and Treatment of Cancer Quality of Life Questionnaire Core 30 scores in patients with head and neck cancer
Musoro, J. Z., Coens, C., Singer, S., Tribius, S., Oosting, S. F., Grønvold, Mogens, Simon, C., Machiels, J. P., Grégoire, V., Velikova, G., Cocks, K., Sprangers, M. A. G., King, M. T. & Bottomley, A., 2020, In: Head and Neck. 42, 11, p. 3141-3152Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Minimally important differences for interpreting the EORTC QLQ-C30 in patients with advanced colorectal cancer treated with chemotherapy
Musoro, J. Z., Sodergren, S. C., Coens, C., Pochesci, A., Terada, M., King, M. T., Sprangers, M. A. G., Grønvold, Mogens, Cocks, K., Velikova, G., Flechtner, H. H. & Bottomley, A., 2020, In: Colorectal Disease. 22, 12, p. 2278-2287 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
New antidepressant utilization pre- and post-bereavement: a population-based study of partners and adult children
Ornstein, K. A., Aldridge, M., Gillezeau, C., Kristensen, M. S., Gazibara, T., Grønvold, Mogens & Thygesen, L. C., 2020, In: Social Psychiatry and Psychiatric Epidemiology. 55, 10, p. 1261-1271 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Patient-reported symptoms and problems at admission to specialized palliative care improved survival prediction in 30,969 cancer patients: A nationwide register-based study
Hansen, Maiken Bang, Nylandsted, L. R., Petersen, M. A., Adsersen, M., Rojas-Concha, L. & Grønvold, Mogens, 2020, In: Palliative Medicine. 34, 6, p. 795-805 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Response to Letter to the Editor: Improving information to caregivers of cancer patients: the Herlev Hospital Empowerment of Relatives through More and Earlier information Supply (HERMES) randomized controlled trial
Lund, Line, Ross, L., Petersen, M. A., Sengelov, L. & Grønvold, Mogens, 2020, In: Supportive Care in Cancer. 28, 2, p. 417 1 p.Research output: Contribution to journal › Comment/debate › Research
- Published
Shorter Recall Period for the Thyroid-Related Patient-Reported Outcome Measure ThyPRO Did Not Change the Accuracy as Evaluated by Repeated Momentary Measurements
Boesen, V. B., Feldt-Rasmussen, Ulla, Bjørner, Jakob Bue, Cramon, P. K., Grønvold, Mogens, Rasmussen, A. K. & Watt, Torquil, 2020, In: Thyroid. 30, 2, p. 185-191 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Should analyses of large, national palliative care data sets with patient reported outcomes (PROs) be restricted to services with high patient participation? A register-based study
Hansen, Maiken Bang, Petersen, M. A., Ross, L. & Grønvold, Mogens, 2020, In: BMC Palliative Care. 19, 11 p., 89.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Similar levels of symptoms and problems were found among patients referred to specialized palliative care by general practitioners and hospital physicians: A nationwide register-based study of 31,139 cancer patients
Hansen, Maiken Bang, Ross, L., Petersen, M. A., Adsersen, M., Rojas-Concha, L. & Grønvold, Mogens, 2020, In: Palliative Medicine. 34, 8, p. 1118-1126 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thresholds for clinical importance were defined for the European Organisation for Research and Treatment of Cancer Computer Adaptive Testing Core-an adaptive measure of core quality of life domains in oncology clinical practice and research
Giesinger, J. M., Loth, F. L. C., Aaronson, N. K., Arraras, J. I., Caocci, G., Efficace, F., Grønvold, Mogens, van Leeuwen, M., Petersen, Morten, Ramage, J., Tomaszewski, K. A., Young, T., Holzner, B. & EORTC Quality of Life Group, E. Q. O. L. G., 2020, In: Journal of Clinical Epidemiology. 117, p. 117-125 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Thresholds for clinical importance were established to improve interpretation of the EORTC QLQ-C30 in clinical practice and research
Giesinger, J. M., Loth, F. L. C., Aaronson, N. K., Arraras, J. I., Caocci, G., Efficace, F., Grønvold, Mogens, van Leeuwen, M., Petersen, Morten, Ramage, J., Tomaszewski, K. A., Young, T., Holzner, B. & EORTC Quality of Life Group, E. Q. O. L. G., 2020, In: Journal of Clinical Epidemiology. 118, p. 1-8 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Updated EORTC QLQ-C30 general population norm data for Germany
Nolte, S., Waldmann, A., Liegl, G., Petersen, M. A., Grønvold, Mogens, Rose, M. & EORTC Quality Life Grp, E. Q. L. G., 2020, In: European Journal of Cancer. 137, p. 161-170 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Which symptoms and problems do advanced cancer patients admitted to specialized palliative care report in addition to those included in the EORTC QLQ-C15-PAL? A register-based national study
Rojas-Concha, L., Hansen, Maiken Bang, Petersen, M. A. & Grønvold, Mogens, 2020, In: Supportive Care in Cancer. 28, 4, p. 1725-1735 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- 2019
- Published
Development and Psychometric Evaluation of an Item Bank for Computerized Adaptive Testing of the EORTC Insomnia Dimension in Cancer Patients (EORTC CAT-SL)
Dirven, L., Petersen, Morten, Aaronson, N. K., Chie, W., Conroy, T., Costantini, A., Hammerlid, E., Velikova, G., Verdonck-de Leeuw, I. M., Young, T. & Grønvold, Mogens, 6 Dec 2019, In: Applied Research in Quality of Life. 18 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
The nature of nausea: prevalence, etiology, and treatment in patients with advanced cancer not receiving antineoplastic treatment
Harder, S., Herrstedt, Jørn, Isaksen, J., Neergaard, M. A., Frandsen, K., Sigaard, J., Mondrup, L., Jespersen, B. A. & Grønvold, Mogens, Aug 2019, In: Supportive Care in Cancer. 27, 8, p. 3071–3080Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Dansk Palliativ Database: Årsrapport 2018
Hansen, M. B., Adsersen, M. & Grønvold, Mogens, Jun 2019, København: DMCG-PAL. 71 p.Research output: Book/Report › Report › Communication
- Published
Cohabitation Status Influenced Admittance to Specialized Palliative Care for Cancer Patients: A Nationwide Study from the Danish Palliative Care Database
Adsersen, M., Thygesen, L. C., Neergaard, M. A., Jensen, A. B., Sjøgren, P., Damkier, A., Clausen, L. M. & Grønvold, Mogens, Feb 2019, In: Journal of Palliative Medicine. 22, 2, p. 164-172 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
A new model of early, integrated palliative care: palliative rehabilitation for newly diagnosed patients with non-resectable cancer
Nottelmann, L., Jensen, L. H., Vejlgaard, T. B. & Grønvold, Mogens, 2019, In: Supportive Care in Cancer. 27, 9, p. 3291-3300 10 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Antiemetic use of olanzapine in patients with advanced cancer: results from an open-label multicenter study
Harder, S., Grønvold, Mogens, Isaksen, J., Sigaard, J., Frandsen, K. B., Neergaard, M. A., Mondrup, L. & Herrstedt, Jørn, 2019, In: Supportive Care in Cancer. 27, 8, p. 2849-2856 8 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Assessing Emotional Functioning with Increased Power: Relative Validity of a Customized EORTC Short Form in the International ACTION Trial
Jabbarian, L. J., Grønvold, Mogens, Petersen, M. A., Christensen, C. A., Deliens, L., van der Heide, A., Kars, M. C., Miccinesi, G., Payne, S., Wilcock, A. & Korfage, I. J., 2019, In: Value in Health. 22, 1, p. 92-98 7 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Current state of quality of life and patient-reported outcomes research
Bottomley, A., Reijneveld, J. C., Koller, M., Flechtner, H., Tomaszewski, K. A., Greimel, E., Ganz, P. A., Ringash, J., Sasseville, M., O'Connor, D., Kluetz, P. G., Campbell, A., Tafuri, G., Grønvold, M., Snyder, C., Gotay, C., Fallowfield, D. L., Apostolidis, K., Wilson, R., Stephens, R. & 16 others, , 2019, In: European Journal of Cancer. 121, p. 55-63 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Establishing anchor-based minimally important differences (MID) for the EORTC QLQ-C30 scales across multiple cancer sites
Musoro, J. Z., Coens, C., King, M., Sprangers, M., Grønvold, M., Cocks, K., Velikova, G., Singer, S., Oosting, S., Brandberg, Y., Cardoso, F., Pochesci, A., Terada, M., Stelmes, J-J., Frederic, F., Katarzyna, P., Reijneveld, J., Dirven, L., Taphoorn, M., Greimel, E. & 3 others, , 2019, In: Quality of Life Research. 28, p. S65-S66 2 p.Research output: Contribution to journal › Conference abstract in journal › Research › peer-review
- Published
Establishing the European Norm for the health-related quality of life domains of the computer-adaptive test EORTC CAT Core
Liegl, G., Petersen, M. A., Grønvold, Mogens, Aaronson, N. K., Costantini, A., Fayers, P. M., Holzner, B., Johnson, C. D., Kemmler, G., Tomaszewski, K. A., Waldmann, A., Young, T. E., Rose, M. & Nolte, S., 2019, In: European journal of cancer (Oxford, England : 1990). 107, p. 133-141 9 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
General population normative data for the EORTC QLQ-C30 health-related quality of life questionnaire based on 15,386 persons across 13 European countries, Canada and the Unites States
Nolte, S., Liegl, G., Petersen, M. A., Aaronson, N. K., Costantini, A., Fayers, P. M., Grønvold, Mogens, Holzner, B., Johnson, C. D., Kemmler, G., Tomaszewski, K. A., Waldmann, A., Young, T. E. & Rose, M., 2019, In: European journal of cancer (Oxford, England : 1990). 107, p. 153-163 11 p.Research output: Contribution to journal › Journal article › Research › peer-review
- Published
Measuring health-related quality of life in colorectal cancer patients: systematic review of measurement properties of the EORTC QLQ-CR29
van der Hout, A., Neijenhuijs, K. I., Jansen, F., van Uden-Kraan, C. F., Aaronson, N. K., Grønvold, Mogens, Holzner, B., Terwee, C. B., van de Poll-Franse, L. V., Cuijpers, P. & Verdonck-de Leeuw, I. M., 2019, In: Supportive Care in Cancer. 27, 7, p. 2395-2412 18 p.Research output: Contribution to journal › Review › Research › peer-review
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Health-related quality of life in early breast cancer: (doctoral thesis)
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Health-Related Quality of Life in EORTC clinical trials – 30 years of progress from methodological developments to making a real impact on oncology practice
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The chronic autoimmune thyroiditis quality of life selenium trial (CATALYST): study protocol for a randomized controlled trial
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