Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
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Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort. / Lécuyer, Lucie; Laouali, Nasser; Viallon, Vivian; Artaud, Fanny; Hébert, James R.; Shivappa, Nitin; Agudo, Antonio; Tjønneland, Anne; Mellemkjær, Lene; Kaaks, Rudolf; Katzke, Verena A.; Schulze, Matthias B.; Frenoy, Pauline; Mancini, Francesca Romana; De Magistris, Maria Santucci; Macciotta, Alessandra; Masala, Giovanna; Agnoli, Claudia; Tumino, Rosario; Boer, Jolanda M.A.; Verschuren, W. M.Monique; Enget Jensen, Torill M.; Olsen, Karina Standahl; Skeie, Guri; Chirlaque, María Dolores; Petrova, Dafina; Castro-Espin, Carlota; Quirós, J. Ramón; Guevara, Marcela; Amiano, Pilar; Borné, Yan; Sandström, Maria; Nilsson, Lena Maria; Heath, Alicia K.; Mayen, Ana Lucia; Huybrechts, Inge; Weiderpass, Elisabete; Boutron-Ruault, Marie Christine; Dossus, Laure; Rinaldi, Sabina; Truong, Thérèse.
In: Clinical Nutrition, Vol. 42, No. 7, 2023, p. 1115-1125.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Associations between dietary inflammatory scores and biomarkers of inflammation in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort
AU - Lécuyer, Lucie
AU - Laouali, Nasser
AU - Viallon, Vivian
AU - Artaud, Fanny
AU - Hébert, James R.
AU - Shivappa, Nitin
AU - Agudo, Antonio
AU - Tjønneland, Anne
AU - Mellemkjær, Lene
AU - Kaaks, Rudolf
AU - Katzke, Verena A.
AU - Schulze, Matthias B.
AU - Frenoy, Pauline
AU - Mancini, Francesca Romana
AU - De Magistris, Maria Santucci
AU - Macciotta, Alessandra
AU - Masala, Giovanna
AU - Agnoli, Claudia
AU - Tumino, Rosario
AU - Boer, Jolanda M.A.
AU - Verschuren, W. M.Monique
AU - Enget Jensen, Torill M.
AU - Olsen, Karina Standahl
AU - Skeie, Guri
AU - Chirlaque, María Dolores
AU - Petrova, Dafina
AU - Castro-Espin, Carlota
AU - Quirós, J. Ramón
AU - Guevara, Marcela
AU - Amiano, Pilar
AU - Borné, Yan
AU - Sandström, Maria
AU - Nilsson, Lena Maria
AU - Heath, Alicia K.
AU - Mayen, Ana Lucia
AU - Huybrechts, Inge
AU - Weiderpass, Elisabete
AU - Boutron-Ruault, Marie Christine
AU - Dossus, Laure
AU - Rinaldi, Sabina
AU - Truong, Thérèse
N1 - Publisher Copyright: © 2023
PY - 2023
Y1 - 2023
N2 - Background: Since the first version of the dietary inflammatory index (DII®) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation. Objective: We aimed to investigate the relationship between four dietary inflammatory scores [DII, two energy-adjusted derivatives (E-DII and E-DIIr), and the Inflammatory Score of the Diet (ISD)], and circulating levels of several inflammatory markers and adipokines. Methods: This study included 17 637 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with at least one marker of inflammation measured in blood. Associations between the four scores and C-reactive protein (CRP), interleukin (IL)6, IL10, IL1RA, tumor necrosis factor-α (TNFα), soluble tumor necrosis factor receptor-1 (sTNFR1), sTNFR2, leptin, soluble leptin receptor (sLeptin R), adiponectin, and High Molecular Weight (HMW) adiponectin were evaluated using multivariable linear regressions adjusted for potential confounders. Results: Positive associations were observed between the four dietary inflammatory scores and levels of CRP, IL6, sTNFR1, sTNFR2 and leptin. However, only the DII and the ISD were positively associated with IL1RA levels and only the DII and the E-DIIr were positively associated with TNFα levels. The proportion of variance of each biomarker explained by the scores was lower than 2%, which was equivalent to the variance explained by smoking status but much lower than that explained by body mass index. Conclusions: Our results suggest that the four dietary inflammatory scores were associated with some biomarkers of inflammation and could be used to assess the inflammatory potential of diet in European adults but are not sufficient to capture the inflammatory status of an individual. These findings can help to better understand the inflammatory potential of diet, but they need to be replicated in studies with repeated dietary measurements.
AB - Background: Since the first version of the dietary inflammatory index (DII®) developed in the past decade, several other versions have been developed. However, to date no study has attempted to compare these versions with respect to their associations with biomarkers of inflammation. Objective: We aimed to investigate the relationship between four dietary inflammatory scores [DII, two energy-adjusted derivatives (E-DII and E-DIIr), and the Inflammatory Score of the Diet (ISD)], and circulating levels of several inflammatory markers and adipokines. Methods: This study included 17 637 participants from the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort with at least one marker of inflammation measured in blood. Associations between the four scores and C-reactive protein (CRP), interleukin (IL)6, IL10, IL1RA, tumor necrosis factor-α (TNFα), soluble tumor necrosis factor receptor-1 (sTNFR1), sTNFR2, leptin, soluble leptin receptor (sLeptin R), adiponectin, and High Molecular Weight (HMW) adiponectin were evaluated using multivariable linear regressions adjusted for potential confounders. Results: Positive associations were observed between the four dietary inflammatory scores and levels of CRP, IL6, sTNFR1, sTNFR2 and leptin. However, only the DII and the ISD were positively associated with IL1RA levels and only the DII and the E-DIIr were positively associated with TNFα levels. The proportion of variance of each biomarker explained by the scores was lower than 2%, which was equivalent to the variance explained by smoking status but much lower than that explained by body mass index. Conclusions: Our results suggest that the four dietary inflammatory scores were associated with some biomarkers of inflammation and could be used to assess the inflammatory potential of diet in European adults but are not sufficient to capture the inflammatory status of an individual. These findings can help to better understand the inflammatory potential of diet, but they need to be replicated in studies with repeated dietary measurements.
KW - Biomarkers
KW - Cohort
KW - Dietary inflammatory scores
KW - EPIC
KW - Inflammation
U2 - 10.1016/j.clnu.2023.05.012
DO - 10.1016/j.clnu.2023.05.012
M3 - Journal article
C2 - 37271707
AN - SCOPUS:85160866795
VL - 42
SP - 1115
EP - 1125
JO - Clinical Nutrition
JF - Clinical Nutrition
SN - 0261-5614
IS - 7
ER -
ID: 360021640