Blood sampling patterns in primary care change several years before a cancer diagnosis
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Blood sampling patterns in primary care change several years before a cancer diagnosis. / Christensen, Mathilde Egelund; Grand, Mia Klinten; Kriegbaum, Margit; Lind, Bent Struer; Grønbæk, Kirsten; Persson, Frederik; Johansen, Christoffer; Andersen, Christen Lykkegaard.
In: Acta oncologica (Stockholm, Sweden), Vol. 63, 2024, p. 17-22.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Blood sampling patterns in primary care change several years before a cancer diagnosis
AU - Christensen, Mathilde Egelund
AU - Grand, Mia Klinten
AU - Kriegbaum, Margit
AU - Lind, Bent Struer
AU - Grønbæk, Kirsten
AU - Persson, Frederik
AU - Johansen, Christoffer
AU - Andersen, Christen Lykkegaard
PY - 2024
Y1 - 2024
N2 - A sudden increase in blood sample requisitions from primary care physicians may indicate an incentive to investigate cer-tain symptoms further. Patients with slowly progressing malig-nancies may debut with insidious symptoms and seek medical attention with increasing frequency, which indeed has been demonstrated through different markers of primary care activ-ity in the last 1–2 years prior to a cancer diagnosis [1, 2]. However, within hematological malignancies in particular, early signs of slowly progressing or pre-malignant conditions may in fact be detectable several years before the malignant disease is diagnosed [3–5]. Identifying early signs of malig-nancy or pre-malignancy is important in order to increase chances of successful treatment and lower morbidity and mor-tality [6–8]. Even in asymptomatic and otherwise low-risk hematological patients, it has been demonstrated that early detection may enable risk stratification for follow-up of the (pre-)malignant conditions, help provide relevant care and improve early disease detection in the right patients [9]. In this descriptive study we aimed to describe the pre-diagnostic activity in primary care going back 15 years prior to the malig-nant diagnosis in order to explore if laboratory activity may indicate that early (pre-)malignant conditions register in pri-mary care years before a diagnosis is made. This was done by describing the blood sampling activity patterns in primary care in both cancer patients to-be and controls, looking at both solid tumors and hematological malignancies. The overall aim of the study was to evaluate the potential for earlier diag-nosis of certain malignant diseases
AB - A sudden increase in blood sample requisitions from primary care physicians may indicate an incentive to investigate cer-tain symptoms further. Patients with slowly progressing malig-nancies may debut with insidious symptoms and seek medical attention with increasing frequency, which indeed has been demonstrated through different markers of primary care activ-ity in the last 1–2 years prior to a cancer diagnosis [1, 2]. However, within hematological malignancies in particular, early signs of slowly progressing or pre-malignant conditions may in fact be detectable several years before the malignant disease is diagnosed [3–5]. Identifying early signs of malig-nancy or pre-malignancy is important in order to increase chances of successful treatment and lower morbidity and mor-tality [6–8]. Even in asymptomatic and otherwise low-risk hematological patients, it has been demonstrated that early detection may enable risk stratification for follow-up of the (pre-)malignant conditions, help provide relevant care and improve early disease detection in the right patients [9]. In this descriptive study we aimed to describe the pre-diagnostic activity in primary care going back 15 years prior to the malig-nant diagnosis in order to explore if laboratory activity may indicate that early (pre-)malignant conditions register in pri-mary care years before a diagnosis is made. This was done by describing the blood sampling activity patterns in primary care in both cancer patients to-be and controls, looking at both solid tumors and hematological malignancies. The overall aim of the study was to evaluate the potential for earlier diag-nosis of certain malignant diseases
U2 - 10.2340/1651-226X.2024.28559
DO - 10.2340/1651-226X.2024.28559
M3 - Journal article
C2 - 38349122
AN - SCOPUS:85185144467
VL - 63
SP - 17
EP - 22
JO - Acta Oncologica
JF - Acta Oncologica
SN - 1100-1704
ER -
ID: 385114198