The EORTC QLQ-C30 is one of the most widely used health-related quality of life (HRQOL) instruments globally. The Quality of Life Group is developing a new version of the EORTC QLQ-C30 questionnaire based on computerized adaptive testing (CAT). The new CAT instrument will measure the same HRQOL concepts as the QLQ-C30 but with higher precision and flexibility. Currently, the development of CAT item banks for 10 out of 14 dimensions has been completed. Completion of the remaining dimensions is expected during 2013. The new EORTC CAT instrument will be tested in an international clinical validation study starting in 2013.