Job strain and the risk of stroke: an individual-participant data meta-analysis
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Job strain and the risk of stroke : an individual-participant data meta-analysis. / Fransson, Eleonor I; Nyberg, Solja T; Heikkilä, Katriina; Alfredsson, Lars; Bjørner, Jakob; Borritz, Marianne; Burr, Hermann; Dragano, Nico; Geuskens, Goedele A; Goldberg, Marcel; Hamer, Mark; Hooftman, Wendela E; Houtman, Irene L; Joensuu, Matti; Jokela, Markus; Knutsson, Anders; Koskenvuo, Markku; Koskinen, Aki; Kumari, Meena; Leineweber, Constanze; Lunau, Thorsten; Madsen, Ida E H; Hanson, Linda L Magnusson; Nielsen, Martin L; Nordin, Maria; Oksanen, Tuula; Pentti, Jaana; Pejtersen, Jan H; Rugulies, Reiner; Salo, Paula; Shipley, Martin J; Steptoe, Andrew; Suominen, Sakari B; Theorell, Töres; Toppinen-Tanner, Salla; Vahtera, Jussi; Virtanen, Marianna; Väänänen, Ari; Westerholm, Peter J M; Westerlund, Hugo; Zins, Marie; Britton, Annie; Brunner, Eric J; Singh-Manoux, Archana; Batty, G David; Kivimäki, Mika.
In: Stroke, Vol. 46, No. 2, 2015, p. 557-559.Research output: Contribution to journal › Letter › Research › peer-review
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TY - JOUR
T1 - Job strain and the risk of stroke
T2 - an individual-participant data meta-analysis
AU - Fransson, Eleonor I
AU - Nyberg, Solja T
AU - Heikkilä, Katriina
AU - Alfredsson, Lars
AU - Bjørner, Jakob
AU - Borritz, Marianne
AU - Burr, Hermann
AU - Dragano, Nico
AU - Geuskens, Goedele A
AU - Goldberg, Marcel
AU - Hamer, Mark
AU - Hooftman, Wendela E
AU - Houtman, Irene L
AU - Joensuu, Matti
AU - Jokela, Markus
AU - Knutsson, Anders
AU - Koskenvuo, Markku
AU - Koskinen, Aki
AU - Kumari, Meena
AU - Leineweber, Constanze
AU - Lunau, Thorsten
AU - Madsen, Ida E H
AU - Hanson, Linda L Magnusson
AU - Nielsen, Martin L
AU - Nordin, Maria
AU - Oksanen, Tuula
AU - Pentti, Jaana
AU - Pejtersen, Jan H
AU - Rugulies, Reiner
AU - Salo, Paula
AU - Shipley, Martin J
AU - Steptoe, Andrew
AU - Suominen, Sakari B
AU - Theorell, Töres
AU - Toppinen-Tanner, Salla
AU - Vahtera, Jussi
AU - Virtanen, Marianna
AU - Väänänen, Ari
AU - Westerholm, Peter J M
AU - Westerlund, Hugo
AU - Zins, Marie
AU - Britton, Annie
AU - Brunner, Eric J
AU - Singh-Manoux, Archana
AU - Batty, G David
AU - Kivimäki, Mika
N1 - © 2015 American Heart Association, Inc.
PY - 2015
Y1 - 2015
N2 - BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.
AB - BACKGROUND AND PURPOSE: Psychosocial stress at work has been proposed to be a risk factor for cardiovascular disease. However, its role as a risk factor for stroke is uncertain.METHODS: We conducted an individual-participant-data meta-analysis of 196 380 males and females from 14 European cohort studies to investigate the association between job strain, a measure of work-related stress, and incident stroke.RESULTS: In 1.8 million person-years at risk (mean follow-up 9.2 years), 2023 first-time stroke events were recorded. The age- and sex-adjusted hazard ratio for job strain relative to no job strain was 1.24 (95% confidence interval, 1.05;1.47) for ischemic stroke, 1.01 (95% confidence interval, 0.75;1.36) for hemorrhagic stroke, and 1.09 (95% confidence interval, 0.94;1.26) for overall stroke. The association with ischemic stroke was robust to further adjustment for socioeconomic status.CONCLUSION: Job strain may be associated with an increased risk of ischemic stroke, but further research is needed to determine whether interventions targeting job strain would reduce stroke risk beyond existing preventive strategies.
KW - Cohort Studies
KW - Female
KW - Humans
KW - Individuality
KW - Job Satisfaction
KW - Male
KW - Prospective Studies
KW - Risk Factors
KW - Stress, Psychological
KW - Stroke
KW - Workload
U2 - 10.1161/STROKEAHA.114.008019
DO - 10.1161/STROKEAHA.114.008019
M3 - Letter
C2 - 25563644
VL - 46
SP - 557
EP - 559
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 2
ER -
ID: 138463327