Late and very-late first-contact schizophrenia and the risk of dementia--a nationwide register based study
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Late and very-late first-contact schizophrenia and the risk of dementia--a nationwide register based study. / Kørner, Alex; Lopez, Ana Garcia; Lauritzen, Lise; Andersen, Per Kragh; Kessing, Lars Vedel; Kørner, Alex; Lopez, Ana Garcia; Lauritzen, Lise; Andersen, Per Kragh; Kessing, Lars Vedel.
In: International Journal of Geriatric Psychiatry, Vol. 24, No. 1, 2009, p. 61-7.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Late and very-late first-contact schizophrenia and the risk of dementia--a nationwide register based study
AU - Kørner, Alex
AU - Lopez, Ana Garcia
AU - Lauritzen, Lise
AU - Andersen, Per Kragh
AU - Kessing, Lars Vedel
AU - Kørner, Alex
AU - Lopez, Ana Garcia
AU - Lauritzen, Lise
AU - Andersen, Per Kragh
AU - Kessing, Lars Vedel
N1 - Keywords: Age of Onset; Aged; Dementia; Denmark; Female; Follow-Up Studies; Hospitals, Psychiatric; Humans; Male; Middle Aged; Osteoarthritis; Prognosis; Registries; Regression Analysis; Risk Assessment; Risk Factors; Schizophrenia
PY - 2009
Y1 - 2009
N2 - OBJECTIVE: To examine whether late and very-late first-contact schizophrenia carry a risk for later development of dementia. METHODS: By linkage of the psychiatric and the somatic nation-wide registers of all out- and in-patients with hospital contact in Denmark, we identified all patients with first ever contact during the period from January 1994 to December 2001 with one of the index main diagnoses: late (age >or=40) and very-late first-contact (age >or=60) schizophrenia. First contact osteoarthritis patients as well as data on the general population were used as controls. The first diagnosis of dementia for each individual at discharge or at out-patient contact was established. The probability of getting a dementia diagnosis is estimated using Poisson regression models with dementia as the outcome of interest. RESULTS: Twelve thousand six hundred and sixteen and 7,712 individuals were included in the late and very-late sample, respectively. Follow-up time was between 3.00 and 4.58 years. The rate ratio (RR) of developing dementia in late and very-late first-contact schizophrenia compared to osteoarthritis patients were 3.47 (95%CI: 2.19-5.50) and 3.15 (95%CI: 1.93-5.14), respectively. Compared to the general population the RR were 2.36 (95%CI: 1.54-3.62) and 2.21 (95%CI: 1.39-3.50), respectively. CONCLUSION: schizophrenic patients with late- and very-late first-contact with the psychiatric hospital system are at two to three times higher risk of subsequently getting a diagnosis of dementia compared to patients with osteoarthritis and compared to the general population.
AB - OBJECTIVE: To examine whether late and very-late first-contact schizophrenia carry a risk for later development of dementia. METHODS: By linkage of the psychiatric and the somatic nation-wide registers of all out- and in-patients with hospital contact in Denmark, we identified all patients with first ever contact during the period from January 1994 to December 2001 with one of the index main diagnoses: late (age >or=40) and very-late first-contact (age >or=60) schizophrenia. First contact osteoarthritis patients as well as data on the general population were used as controls. The first diagnosis of dementia for each individual at discharge or at out-patient contact was established. The probability of getting a dementia diagnosis is estimated using Poisson regression models with dementia as the outcome of interest. RESULTS: Twelve thousand six hundred and sixteen and 7,712 individuals were included in the late and very-late sample, respectively. Follow-up time was between 3.00 and 4.58 years. The rate ratio (RR) of developing dementia in late and very-late first-contact schizophrenia compared to osteoarthritis patients were 3.47 (95%CI: 2.19-5.50) and 3.15 (95%CI: 1.93-5.14), respectively. Compared to the general population the RR were 2.36 (95%CI: 1.54-3.62) and 2.21 (95%CI: 1.39-3.50), respectively. CONCLUSION: schizophrenic patients with late- and very-late first-contact with the psychiatric hospital system are at two to three times higher risk of subsequently getting a diagnosis of dementia compared to patients with osteoarthritis and compared to the general population.
U2 - 10.1002/gps.2075
DO - 10.1002/gps.2075
M3 - Journal article
C2 - 18561206
VL - 24
SP - 61
EP - 67
JO - International Journal of Geriatric Psychiatry
JF - International Journal of Geriatric Psychiatry
SN - 0885-6230
IS - 1
ER -
ID: 11480100