Randomised controlled trial of genetic amniocentesis in 4606 low-risk women.

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

Randomised controlled trial of genetic amniocentesis in 4606 low-risk women. / Tabor, A; Philip, J; Madsen, Mette; Bang, J; Obel, E B; Nørgaard-Pedersen, B.

In: Lancet, Vol. 1, No. 8493, 1986, p. 1287-93.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Tabor, A, Philip, J, Madsen, M, Bang, J, Obel, EB & Nørgaard-Pedersen, B 1986, 'Randomised controlled trial of genetic amniocentesis in 4606 low-risk women.', Lancet, vol. 1, no. 8493, pp. 1287-93.

APA

Tabor, A., Philip, J., Madsen, M., Bang, J., Obel, E. B., & Nørgaard-Pedersen, B. (1986). Randomised controlled trial of genetic amniocentesis in 4606 low-risk women. Lancet, 1(8493), 1287-93.

Vancouver

Tabor A, Philip J, Madsen M, Bang J, Obel EB, Nørgaard-Pedersen B. Randomised controlled trial of genetic amniocentesis in 4606 low-risk women. Lancet. 1986;1(8493):1287-93.

Author

Tabor, A ; Philip, J ; Madsen, Mette ; Bang, J ; Obel, E B ; Nørgaard-Pedersen, B. / Randomised controlled trial of genetic amniocentesis in 4606 low-risk women. In: Lancet. 1986 ; Vol. 1, No. 8493. pp. 1287-93.

Bibtex

@article{a4732d60493c11ddb7b4000ea68e967b,
title = "Randomised controlled trial of genetic amniocentesis in 4606 low-risk women.",
abstract = "Outcome of pregnancy after amniocentesis was studied in a randomised controlled trial of 4606 women, age-range 25-34 years, without known risk of genetic disease. Spontaneous abortion rate was 1.7% in the study group after amniocentesis and 0.7% in the control group after ultrasound (relative risk 2.3). In the study group, increased levels of maternal serum alpha-fetoprotein before amniocentesis, perforation of the placenta during amniocentesis, and withdrawal of discoloured amniotic fluid were associated with an increased risk of spontaneous abortion. In the first six weeks after amniocentesis/ultrasound scan, amniotic fluid leakage occurred more often in the study group but there was no difference in the rate of vaginal bleeding. Frequency of postural malformations in the infants in the two groups was the same. In the study group, respiratory distress syndrome was diagnosed more often (relative risk 2.1) and more babies were treated for pneumonia (relative risk 2.5).",
author = "A Tabor and J Philip and Mette Madsen and J Bang and Obel, {E B} and B N{\o}rgaard-Pedersen",
note = "Keywords: Abortion, Spontaneous; Adult; Amniocentesis; Clinical Trials as Topic; Female; Gestational Age; Humans; Infant, Newborn; Male; Pilot Projects; Pneumonia; Pregnancy; Pregnancy Complications; Random Allocation; Respiratory Distress Syndrome, Newborn; Time Factors; Ultrasonography; alpha-Fetoproteins",
year = "1986",
language = "English",
volume = "1",
pages = "1287--93",
journal = "The Lancet",
issn = "0140-6736",
publisher = "TheLancet Publishing Group",
number = "8493",

}

RIS

TY - JOUR

T1 - Randomised controlled trial of genetic amniocentesis in 4606 low-risk women.

AU - Tabor, A

AU - Philip, J

AU - Madsen, Mette

AU - Bang, J

AU - Obel, E B

AU - Nørgaard-Pedersen, B

N1 - Keywords: Abortion, Spontaneous; Adult; Amniocentesis; Clinical Trials as Topic; Female; Gestational Age; Humans; Infant, Newborn; Male; Pilot Projects; Pneumonia; Pregnancy; Pregnancy Complications; Random Allocation; Respiratory Distress Syndrome, Newborn; Time Factors; Ultrasonography; alpha-Fetoproteins

PY - 1986

Y1 - 1986

N2 - Outcome of pregnancy after amniocentesis was studied in a randomised controlled trial of 4606 women, age-range 25-34 years, without known risk of genetic disease. Spontaneous abortion rate was 1.7% in the study group after amniocentesis and 0.7% in the control group after ultrasound (relative risk 2.3). In the study group, increased levels of maternal serum alpha-fetoprotein before amniocentesis, perforation of the placenta during amniocentesis, and withdrawal of discoloured amniotic fluid were associated with an increased risk of spontaneous abortion. In the first six weeks after amniocentesis/ultrasound scan, amniotic fluid leakage occurred more often in the study group but there was no difference in the rate of vaginal bleeding. Frequency of postural malformations in the infants in the two groups was the same. In the study group, respiratory distress syndrome was diagnosed more often (relative risk 2.1) and more babies were treated for pneumonia (relative risk 2.5).

AB - Outcome of pregnancy after amniocentesis was studied in a randomised controlled trial of 4606 women, age-range 25-34 years, without known risk of genetic disease. Spontaneous abortion rate was 1.7% in the study group after amniocentesis and 0.7% in the control group after ultrasound (relative risk 2.3). In the study group, increased levels of maternal serum alpha-fetoprotein before amniocentesis, perforation of the placenta during amniocentesis, and withdrawal of discoloured amniotic fluid were associated with an increased risk of spontaneous abortion. In the first six weeks after amniocentesis/ultrasound scan, amniotic fluid leakage occurred more often in the study group but there was no difference in the rate of vaginal bleeding. Frequency of postural malformations in the infants in the two groups was the same. In the study group, respiratory distress syndrome was diagnosed more often (relative risk 2.1) and more babies were treated for pneumonia (relative risk 2.5).

M3 - Journal article

C2 - 2423826

VL - 1

SP - 1287

EP - 1293

JO - The Lancet

JF - The Lancet

SN - 0140-6736

IS - 8493

ER -

ID: 4853509