Assembly of Alzheimer-like filaments from full-length tau protein
Research output: Contribution to journal › Journal article › Research › peer-review
The principal fibrous component of neurofibrillary pathology in Alzheimer's disease, the paired helical filament, is formed from hyperphosphorylated microtubule-associated protein tau. Here we show that recombinant tau protein either in a non-phosphorylated state or following phosphorylation with brain extract can be assembled in vitro into filaments resembling those seen in Alzheimer's disease. © 1994.
| Original language | English |
|---|---|
| Journal | FEBS Letters |
| Volume | 337 |
| Issue number | 2 |
| Pages (from-to) | 135-138 |
| Number of pages | 4 |
| ISSN | 0014-5793 |
| DOIs | |
| Publication status | Published - 10 Jan 1994 |
- Alzheimer's disease, Hyper-phosphorylation, Microtubule-associated protein tau, Paired helical filament
Research areas
ID: 252064208