The Relationship Between Harmful Alcohol Use and Antiretroviral Non-adherence in People Accessing HIV Treatment in Cape Town, South Africa: An Event-Level Analysis
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The Relationship Between Harmful Alcohol Use and Antiretroviral Non-adherence in People Accessing HIV Treatment in Cape Town, South Africa : An Event-Level Analysis. / Rose, Alexandra L.; Belus, Jennifer M.; Ma, Tianzhou; Lee, Jasper S.; Wan, Christine; De los Reyes, Andres; Joska, John A.; Andersen, Lena S.; Myers, Bronwyn; Magidson, Jessica F.
In: AIDS and Behavior, Vol. 26, 2022, p. 2055–2066.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - The Relationship Between Harmful Alcohol Use and Antiretroviral Non-adherence in People Accessing HIV Treatment in Cape Town, South Africa
T2 - An Event-Level Analysis
AU - Rose, Alexandra L.
AU - Belus, Jennifer M.
AU - Ma, Tianzhou
AU - Lee, Jasper S.
AU - Wan, Christine
AU - De los Reyes, Andres
AU - Joska, John A.
AU - Andersen, Lena S.
AU - Myers, Bronwyn
AU - Magidson, Jessica F.
PY - 2022
Y1 - 2022
N2 - Harmful alcohol consumption can significantly compromise adherence to antiretroviral therapy (ART). Prior research has identified aggregate relationships between alcohol use and ART non-adherence, largely relying on concurrent assessment of these domains. There is relatively limited evidence on more nuanced day-level associations between alcohol use and ART non-adherence, despite potentially important clinical implications. We recruited adults with HIV treatment adherence challenges and harmful alcohol use (n=53) from HIV care in South Africa. We examined relationships between alcohol use and same and next day ART adherence, accounting for the role of weekends/holidays and participant demographics, including gender. Results demonstrated that ART adherence was significantly worse on weekend/holiday days. Next day adherence was significantly worse in the context of weekend alcohol use and among men. These results suggest the importance of tailoring intervention strategies to support ART adherence during weekend drinking and for men engaged in heavy episodic drinking.
AB - Harmful alcohol consumption can significantly compromise adherence to antiretroviral therapy (ART). Prior research has identified aggregate relationships between alcohol use and ART non-adherence, largely relying on concurrent assessment of these domains. There is relatively limited evidence on more nuanced day-level associations between alcohol use and ART non-adherence, despite potentially important clinical implications. We recruited adults with HIV treatment adherence challenges and harmful alcohol use (n=53) from HIV care in South Africa. We examined relationships between alcohol use and same and next day ART adherence, accounting for the role of weekends/holidays and participant demographics, including gender. Results demonstrated that ART adherence was significantly worse on weekend/holiday days. Next day adherence was significantly worse in the context of weekend alcohol use and among men. These results suggest the importance of tailoring intervention strategies to support ART adherence during weekend drinking and for men engaged in heavy episodic drinking.
KW - HIV
KW - Alcohol
KW - Antiretroviral therapy
KW - South Africa
KW - Treatment adherence
U2 - 10.1007/s10461-021-03552-x
DO - 10.1007/s10461-021-03552-x
M3 - Journal article
C2 - 35022939
VL - 26
SP - 2055
EP - 2066
JO - AIDS & Behavior
JF - AIDS & Behavior
SN - 1090-7165
ER -
ID: 290517655