The association between maternal malaria exposure and cardiometabolic risk in the offspring: a 20 year follow-up study

The objective is to determine the possible additive, detrimental effect of maternal malaria in the placenta on the offspring in regard to epigenetic changes in skeletal muscle and subsequent risk of cardiometabolic disease in adulthood.

Private photo: Danish-Tanzanian research team collecting data in the lab at Teule Hospital in Muheza, Tanzania. From left: Performance of fitness test; Euglycaemic, hyper-insulinaemic clamp test; Skeletal muscle biopsy.

Data were collected in 2010-11 in 100 men and women 18-22 years of age. The study is a follow-up study on a malaria in pregnancy study conducted during the period 1988-92.

The study has been supported by the Cluster of International Health Grant at University of Copenhagen, the Novo Nordisk Foundation and Brdr. Hartmann's Foundation.