Objectives: To understand the impact of United States President’s Emergency Plan for AIDS Relief (PEPFAR’s) DREAMS (Determined, Resilient, Empowered, AIDS-Free, Mentored, and Safe) Partnership on new HIV diagnoses among women in antenatal care (ANC) settings in 10 African countries from 2015 to 2020. Design: We modeled spatiotemporal changes in new HIV diagnoses among women in ANC settings using PEPFAR data. Statistical tests were performed in R to compare differences in new diagnoses rates between DREAMS and non-DREAMS subnational units (SNUs) and to explore predictors of new diagnoses declines within DREAMS SNUs. Methods: We used a predictive geospatial model to forecast the rate of new diagnoses for each time period in a 5 km grid cell (n ¼ 861 SNUs). Linear model analyses were conducted using predictor variables: urbanicity, DREAMS geographic footprint, ‘layering’ proxy, and community-level male viral load suppression. Results: New HIV diagnoses in ANC from 2015 to 2020 declined in nearly all SNUs. ‘Always’ DREAMS SNUs reported declines of 45% while ‘Never’ DREAMS SNUs reported a decline of only 37% (F ¼ 8.1, 1 and 829 DF, P < 0.01). Within Always DREAMS SNUs, greater declines were seen in areas with a higher number of minimum services in their DREAMS primary package (t ¼ 2.77, P < 0.01). Conclusion: New HIV diagnoses among women are declining in both DREAMS and non-DREAMS SNUs; mirroring HIV incidence decreases and reflecting increasing community viral load suppression and voluntary male medical circumcision rates. DREAMS programming may have contributed to accelerated declines of new HIV diagnoses in DREAMS SNUs compared with non-DREAMS SNUs. Increased progress is needed to further reduce the disparities between adolescent girls and young women (AGYW) and young men to achieve epidemic control.