Age-specific differences between conventional and ambulatory daytime blood pressure values

Research output: Contribution to journalJournal articleResearchpeer-review

  • David Conen
  • Stefanie Aeschbacher
  • Lutgarde Thijs
  • Yan Li
  • José Boggia
  • Kei Asayama
  • Tine W Hansen
  • Masahiro Kikuya
  • Kristina Björklund-Bodegård
  • Takayoshi Ohkubo
  • Jørgen Jeppesen
  • Yu-Mei Gu
  • Eamon Dolan
  • Tatiana Kuznetsova
  • Katarzyna Stolarz-Skrzypek
  • Valérie Tikhonoff
  • Tobias Schoen
  • Sofia Malyutina
  • Edoardo Casiglia
  • Yuri Nikitin
  • Lars Lind
  • Edgardo Sandoya
  • Kalina Kawecka-Jaszcz
  • Luis Mena
  • Gladys E Maestre
  • Jan Filipovský
  • Yutaka Imai
  • Eoin O'Brien
  • Ji-Guang Wang
  • Lorenz Risch
  • Jan A Staessen

Mean daytime ambulatory blood pressure (BP) values are considered to be lower than conventional BP values, but data on this relation among younger individuals <50 years are scarce. Conventional and 24-hour ambulatory BP were measured in 9550 individuals not taking antihypertensive treatment from 13 population-based cohorts. We compared individual differences between daytime ambulatory and conventional BP according to 10-year age categories. Age-specific prevalences of white coat and masked hypertension were calculated. Among individuals aged 18 to 30, 30 to 40, and 40 to 50 years, mean daytime BP was significantly higher than the corresponding conventional BP (6.0, 5.2, and 4.7 mm Hg for systolic; 2.5, 2.7, and 1.7 mm Hg for diastolic BP; all P<0.0001). In individuals aged 60 to 70 and ≥70 years, conventional BP was significantly higher than daytime ambulatory BP (5.0 and 13.0 mm Hg for systolic; 2.0 and 4.2 mm Hg for diastolic BP; all P<0.0001).The prevalence of white coat hypertension exponentially increased from 2.2% to 19.5% from those aged 18 to 30 years to those aged ≥70 years, with little variation between men and women (8.0% versus 6.1%; P=0.0003). Masked hypertension was more prevalent among men (21.1% versus 11.4%; P<0.0001). The age-specific prevalences of masked hypertension were 18.2%, 27.3%, 27.8%, 20.1%, 13.6%, and 10.2% among men and 9.0%, 9.9%, 12.2%, 11.9%, 14.7%, and 12.1% among women. In conclusion, this large collaborative analysis showed that the relation between daytime ambulatory and conventional BP strongly varies by age. These findings may have implications for diagnosing hypertension and its subtypes in clinical practice.

Original languageEnglish
Issue number5
Pages (from-to)1073-1079
Number of pages7
Publication statusPublished - Nov 2014

    Research areas

  • Adolescent, Adult, Aging, Blood Pressure, Blood Pressure Monitoring, Ambulatory, Circadian Rhythm, Cohort Studies, Cross-Sectional Studies, Female, Humans, Male, Masked Hypertension, Middle Aged, Office Visits, Prevalence, White Coat Hypertension, Young Adult

ID: 138810988