Increased risk of neonatal complications and infections in children of kidney-transplanted women: A nationwide controlled cohort study
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Increased risk of neonatal complications and infections in children of kidney-transplanted women : A nationwide controlled cohort study. / Egerup, Pia; Carlson, Nicholas; Bruun Oestergaard, Louise; Blanche, Paul; Scott, James R.; Hornum, Mads; Torp-Pedersen, Christian; Christiansen, Ole Bjarne.
In: American Journal of Transplantation, Vol. 21, No. 3, 2021, p. 1171-1178.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Increased risk of neonatal complications and infections in children of kidney-transplanted women
T2 - A nationwide controlled cohort study
AU - Egerup, Pia
AU - Carlson, Nicholas
AU - Bruun Oestergaard, Louise
AU - Blanche, Paul
AU - Scott, James R.
AU - Hornum, Mads
AU - Torp-Pedersen, Christian
AU - Christiansen, Ole Bjarne
PY - 2021
Y1 - 2021
N2 - Information related to short- and long-term risks of children born to kidney-transplanted women remains limited. With the aim of investigating the risk of neonatal complications, and the short- and long-term risk of infections in offspring of kidney-transplanted women, all children born to kidney-transplanted women in Denmark from 1964 to 2016 were identified in a nationwide retrospective matched cohort study. A total of 124 children of kidney-transplanted women were identified and matched on gender, birth year, and number of siblings at birth 1:10 with children born to nontransplanted women identified in the Danish general population. Prevalence of low birth weight (37.9%, risk ratio [RR] = 12.61; 95% confidence interval [CI], 8.5-18.5), premature birth (46.0%, RR = 11.32; 95% CI, 8.1-15.7) and malformations (11.3%, RR = 1.98; 95% CI, 1.2-3.4) was increased in children of kidney-transplanted women compared with controls. Similarly, prevalence of hospitalization due to infection was increased during the first year of life (21.0%, RR = 1.94; 95% CI, 1.3-2.8), from age 1 to 5 (34.2%, RR = 1.89; 95% CI, 1.4-2.5), and overall (41.9%, RR = 1.67; 95% CI, 1.3-2.1). The risk of infection was also higher in children of kidney-transplanted mothers born preterm or with low birth weight compared with similar controls. In conclusion, risk of neonatal complications, malformations, and both early and late infection were increased in children born to kidney-transplanted women.
AB - Information related to short- and long-term risks of children born to kidney-transplanted women remains limited. With the aim of investigating the risk of neonatal complications, and the short- and long-term risk of infections in offspring of kidney-transplanted women, all children born to kidney-transplanted women in Denmark from 1964 to 2016 were identified in a nationwide retrospective matched cohort study. A total of 124 children of kidney-transplanted women were identified and matched on gender, birth year, and number of siblings at birth 1:10 with children born to nontransplanted women identified in the Danish general population. Prevalence of low birth weight (37.9%, risk ratio [RR] = 12.61; 95% confidence interval [CI], 8.5-18.5), premature birth (46.0%, RR = 11.32; 95% CI, 8.1-15.7) and malformations (11.3%, RR = 1.98; 95% CI, 1.2-3.4) was increased in children of kidney-transplanted women compared with controls. Similarly, prevalence of hospitalization due to infection was increased during the first year of life (21.0%, RR = 1.94; 95% CI, 1.3-2.8), from age 1 to 5 (34.2%, RR = 1.89; 95% CI, 1.4-2.5), and overall (41.9%, RR = 1.67; 95% CI, 1.3-2.1). The risk of infection was also higher in children of kidney-transplanted mothers born preterm or with low birth weight compared with similar controls. In conclusion, risk of neonatal complications, malformations, and both early and late infection were increased in children born to kidney-transplanted women.
KW - clinical research/practice
KW - epidemiology
KW - immunosuppression/immune modulation
KW - immunosuppressive regimens
KW - innate immunity
KW - kidney transplantation/nephrology
KW - obstetrics and gynecology
KW - pregnancy
KW - reproductive biology
U2 - 10.1111/ajt.16259
DO - 10.1111/ajt.16259
M3 - Journal article
C2 - 32786135
AN - SCOPUS:85090972793
VL - 21
SP - 1171
EP - 1178
JO - American Journal of Transplantation
JF - American Journal of Transplantation
SN - 1600-6135
IS - 3
ER -
ID: 249242834