Mild Cognitive Impairment Status and Mobility Performance: An Analysis From the Boston RISE Study
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Mild Cognitive Impairment Status and Mobility Performance : An Analysis From the Boston RISE Study. / Pedersen, Mette; Holt, Nicole E; Grande, Laura; Kurlinski, Laura A; Beauchamp, Marla K; Kiely, Dan K; Petersen, Janne; Leveille, Suzanne; Bean, Jonathan F.
In: Journals of Gerontology. Series A: Biological Sciences & Medical Sciences, Vol. 69, No. 12, 12.2014, p. 1511-1518.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Mild Cognitive Impairment Status and Mobility Performance
T2 - An Analysis From the Boston RISE Study
AU - Pedersen, Mette
AU - Holt, Nicole E
AU - Grande, Laura
AU - Kurlinski, Laura A
AU - Beauchamp, Marla K
AU - Kiely, Dan K
AU - Petersen, Janne
AU - Leveille, Suzanne
AU - Bean, Jonathan F
N1 - © The Author 2014. Published by Oxford University Press on behalf of The Gerontological Society of America. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.
PY - 2014/12
Y1 - 2014/12
N2 - BACKGROUND: The prevalence of mild cognitive impairment (MCI) and mobility limitations is high among older adults. The aim of this study was to investigate the association between MCI status and both performance-based and self-report measures of mobility in community-dwelling older adults.METHODS: An analysis was conducted on baseline data from the Boston Rehabilitative Impairment Study in the Elderly study, a cohort study of 430 primary care patients aged 65 or older. Neuropsychological tests identified participants with MCI and further subclassified those with impairment in memory domains (aMCI), nonmemory domains (naMCI), and multiple domains (mdMCI). Linear regression models were used to assess the association between MCI status and mobility performance in the Habitual Gait Speed, Figure of 8 Walk, Short Physical Performance Battery, and self-reported Late Life Function and Disability Instrument's Basic Lower Extremity and Advanced Lower Extremity function scales.RESULTS: Participants had a mean age of 76.6 years, and 42% were characterized with MCI. Participants with MCI performed significantly worse than participants without MCI (No-MCI) on all performance and self-report measures (p < .01). All MCI subtypes performed significantly worse than No-MCI on all mobility measures (p < .05) except for aMCI versus No-MCI on the Figure of 8 Walk (p = .054) and Basic Lower Extremity (p = .11). Moreover, compared with aMCI, mdMCI manifested worse performance on the Figure of 8 Walk and Short Physical Performance Battery, and naMCI manifested worse performance on Short Physical Performance Battery and Basic Lower Extremity.CONCLUSIONS: Among older community-dwelling primary care patients, performance on a broad range of mobility measures was worse among those with MCI, appearing poorest among those with nonmemory MCI.
AB - BACKGROUND: The prevalence of mild cognitive impairment (MCI) and mobility limitations is high among older adults. The aim of this study was to investigate the association between MCI status and both performance-based and self-report measures of mobility in community-dwelling older adults.METHODS: An analysis was conducted on baseline data from the Boston Rehabilitative Impairment Study in the Elderly study, a cohort study of 430 primary care patients aged 65 or older. Neuropsychological tests identified participants with MCI and further subclassified those with impairment in memory domains (aMCI), nonmemory domains (naMCI), and multiple domains (mdMCI). Linear regression models were used to assess the association between MCI status and mobility performance in the Habitual Gait Speed, Figure of 8 Walk, Short Physical Performance Battery, and self-reported Late Life Function and Disability Instrument's Basic Lower Extremity and Advanced Lower Extremity function scales.RESULTS: Participants had a mean age of 76.6 years, and 42% were characterized with MCI. Participants with MCI performed significantly worse than participants without MCI (No-MCI) on all performance and self-report measures (p < .01). All MCI subtypes performed significantly worse than No-MCI on all mobility measures (p < .05) except for aMCI versus No-MCI on the Figure of 8 Walk (p = .054) and Basic Lower Extremity (p = .11). Moreover, compared with aMCI, mdMCI manifested worse performance on the Figure of 8 Walk and Short Physical Performance Battery, and naMCI manifested worse performance on Short Physical Performance Battery and Basic Lower Extremity.CONCLUSIONS: Among older community-dwelling primary care patients, performance on a broad range of mobility measures was worse among those with MCI, appearing poorest among those with nonmemory MCI.
KW - Aged
KW - Aging
KW - Boston
KW - Cognition
KW - Cross-Sectional Studies
KW - Disease Progression
KW - Female
KW - Humans
KW - Male
KW - Memory
KW - Mild Cognitive Impairment
KW - Mobility Limitation
KW - Neuropsychological Tests
KW - Prevalence
KW - Walking
U2 - 10.1093/gerona/glu063
DO - 10.1093/gerona/glu063
M3 - Journal article
C2 - 24799356
VL - 69
SP - 1511
EP - 1518
JO - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
JF - Journals of Gerontology. Series A: Biological Sciences & Medical Sciences
SN - 1079-5006
IS - 12
ER -
ID: 138422051