TY - JOUR

T1 - Trajectories of Infant Weight Gain from Birth to 12 Months and Adult-Onset Coronary Heart Disease

AU - Blond, Kim

AU - Jensen, Britt W.

AU - Petersen, Janne

AU - Baker, Jennifer L.

AU - Bjerregaard, Lise G.

PY - 2022

Y1 - 2022

N2 - ObjectiveTo investigate associations between infant weight gain trajectories and coronary heart disease (CHD).Study designWe followed 3645 Danish individuals born between 1959 and 1961 with information on weight at birth and at age 2 weeks and 1, 2, 3, 4, 6, or 12 months. Sex-specific weight trajectories were generated using latent class modeling. Cases of CHD (n = 279) were identified from national health registers. Hazard ratios (HRs) were estimated by Cox regression with sequential adjustment for sex, socioeconomic status, prepregnancy body mass index, maternal smoking, preterm birth, parity, and birth weight.ResultsWe identified 5 trajectories of weight development in infancy in our cohort: very low–moderate increase (11.5% of the population), low-marked increase (13.9%), low-stable increase (32.4%), average-stable increase (29.8%), and high-moderate increase (12.4%). Compared with the average-stable increasing trajectory, having a very low–moderately increasing weight trajectory in infancy was associated with a higher frequency of adult CHD (HR, 1.56; 95% CI, 1.04-2.33). The higher frequency remained after adjustment for maternal factors but was slightly attenuated after additional adjustment for preterm birth and parity (HR, 1.41; 95% CI, 0.91-2.23) and disappeared after adjustment for birth weight (HR, 0.78; 95% CI, 0.44-1.37). The associations with CHD did not differ between the other trajectories and the average-stable increasing trajectory.ConclusionsAlthough a pattern of very low–moderate increasing weight during infancy was associated with a higher frequency of adult CHD, the association did not persist after adjustment for birth weight, highlighting the importance of prenatal exposures.

AB - ObjectiveTo investigate associations between infant weight gain trajectories and coronary heart disease (CHD).Study designWe followed 3645 Danish individuals born between 1959 and 1961 with information on weight at birth and at age 2 weeks and 1, 2, 3, 4, 6, or 12 months. Sex-specific weight trajectories were generated using latent class modeling. Cases of CHD (n = 279) were identified from national health registers. Hazard ratios (HRs) were estimated by Cox regression with sequential adjustment for sex, socioeconomic status, prepregnancy body mass index, maternal smoking, preterm birth, parity, and birth weight.ResultsWe identified 5 trajectories of weight development in infancy in our cohort: very low–moderate increase (11.5% of the population), low-marked increase (13.9%), low-stable increase (32.4%), average-stable increase (29.8%), and high-moderate increase (12.4%). Compared with the average-stable increasing trajectory, having a very low–moderately increasing weight trajectory in infancy was associated with a higher frequency of adult CHD (HR, 1.56; 95% CI, 1.04-2.33). The higher frequency remained after adjustment for maternal factors but was slightly attenuated after additional adjustment for preterm birth and parity (HR, 1.41; 95% CI, 0.91-2.23) and disappeared after adjustment for birth weight (HR, 0.78; 95% CI, 0.44-1.37). The associations with CHD did not differ between the other trajectories and the average-stable increasing trajectory.ConclusionsAlthough a pattern of very low–moderate increasing weight during infancy was associated with a higher frequency of adult CHD, the association did not persist after adjustment for birth weight, highlighting the importance of prenatal exposures.

U2 - 10.1016/j.jpeds.2022.03.055

DO - 10.1016/j.jpeds.2022.03.055

M3 - Journal article

C2 - 35398117

VL - 246

SP - 123

EP - 130

JO - Journal of Pediatrics

JF - Journal of Pediatrics

SN - 0022-3476

ER -