A competing risks approach to "biologic" interaction

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Standard

A competing risks approach to "biologic" interaction. / Andersen, Per Kragh; Skrondal, Anders.

In: Lifetime Data Analysis, Vol. 21, No. 2, 04.2015, p. 300-314.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Andersen, PK & Skrondal, A 2015, 'A competing risks approach to "biologic" interaction', Lifetime Data Analysis, vol. 21, no. 2, pp. 300-314. https://doi.org/10.1007/s10985-015-9318-z

APA

Andersen, P. K., & Skrondal, A. (2015). A competing risks approach to "biologic" interaction. Lifetime Data Analysis, 21(2), 300-314. https://doi.org/10.1007/s10985-015-9318-z

Vancouver

Andersen PK, Skrondal A. A competing risks approach to "biologic" interaction. Lifetime Data Analysis. 2015 Apr;21(2):300-314. https://doi.org/10.1007/s10985-015-9318-z

Author

Andersen, Per Kragh ; Skrondal, Anders. / A competing risks approach to "biologic" interaction. In: Lifetime Data Analysis. 2015 ; Vol. 21, No. 2. pp. 300-314.

Bibtex

@article{05afb518e092453aa42160865bddf27b,
title = "A competing risks approach to {"}biologic{"} interaction",
abstract = "In epidemiology, the concepts of {"}biologic{"} and {"}statistical{"} interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas.",
author = "Andersen, {Per Kragh} and Anders Skrondal",
year = "2015",
month = apr,
doi = "10.1007/s10985-015-9318-z",
language = "English",
volume = "21",
pages = "300--314",
journal = "Lifetime Data Analysis",
issn = "1380-7870",
publisher = "Springer",
number = "2",

}

RIS

TY - JOUR

T1 - A competing risks approach to "biologic" interaction

AU - Andersen, Per Kragh

AU - Skrondal, Anders

PY - 2015/4

Y1 - 2015/4

N2 - In epidemiology, the concepts of "biologic" and "statistical" interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas.

AB - In epidemiology, the concepts of "biologic" and "statistical" interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas.

U2 - 10.1007/s10985-015-9318-z

DO - 10.1007/s10985-015-9318-z

M3 - Journal article

C2 - 25613424

VL - 21

SP - 300

EP - 314

JO - Lifetime Data Analysis

JF - Lifetime Data Analysis

SN - 1380-7870

IS - 2

ER -

ID: 135436589