A competing risks approach to "biologic" interaction

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In epidemiology, the concepts of "biologic" and "statistical" interactions have been the subject of extensive debate. We present a new approach to biologic interaction based on Rothman's original (Am J Epidemiol, 104:587-592, 1976) discussion of sufficient causes. We do this in a probabilistic framework using competing risks and argue that sufficient cause interaction between two factors can be evaluated via the parameters in a particular statistical model, the additive hazard rate model. We present empirical conditions for presence of sufficient cause interaction and an example based on data from a liver cirrhosis trial illustrates the ideas.

Original languageEnglish
JournalLifetime Data Analysis
Volume21
Issue number2
Pages (from-to)300-314
Number of pages15
ISSN1380-7870
DOIs
Publication statusPublished - Apr 2015

ID: 135436589