Association between days alive without life support/out of hospital and health-related quality of life
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Association between days alive without life support/out of hospital and health-related quality of life. / Granholm, Anders; Schjorring, Olav Lilleholt; Jensen, Aksel Karl Georg; Kaas-Hansen, Benjamin Skov; Munch, Marie Warrer; Klitgaard, Thomas Lass; Crescioli, Elena; Kjaer, Maj-Brit Norregaard; Strom, Thomas; Lange, Theis; Perner, Anders; Rasmussen, Bodil Steen; Moller, Morten Hylander.
In: Acta Anaesthesiologica Scandinavica, Vol. 67, No. 6, 2023, p. 762-771.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Association between days alive without life support/out of hospital and health-related quality of life
AU - Granholm, Anders
AU - Schjorring, Olav Lilleholt
AU - Jensen, Aksel Karl Georg
AU - Kaas-Hansen, Benjamin Skov
AU - Munch, Marie Warrer
AU - Klitgaard, Thomas Lass
AU - Crescioli, Elena
AU - Kjaer, Maj-Brit Norregaard
AU - Strom, Thomas
AU - Lange, Theis
AU - Perner, Anders
AU - Rasmussen, Bodil Steen
AU - Moller, Morten Hylander
PY - 2023
Y1 - 2023
N2 - Background: Trials in critically ill patients increasingly focus on days alive without life support (DAWOLS) or days alive out of hospital (DAOOH) and health-related quality of life (HRQoL). DAWOLS and DAOOH convey more information than mortality and are simpler and faster to collect than HRQoL. However, whether these outcomes are associated with HRQoL is uncertain. We thus aimed to assess the associations between DAWOLS and DAOOH and long-term HRQoL.Methods: Secondary analysis of the COVID STEROID 2 trial including adults with COVID-19 and severe hypoxaemia and the Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU) trial including adult intensive care unit patients with acute hypoxaemic respiratory failure. Associations between DAWOLS and DAOOH at day 28 and 90 and long-term HRQoL (after 6 or 12 months) using the EuroQol 5-dimension 5-level survey (EQ VAS and EQ-5D-5L index values) were assessed using flexible models and evaluated using measures of fit and prediction adequacy in both datasets (comprising internal performance and external validation), non-parametric correlation coefficients and graphical presentations.Results: We found no strong associations between DAWOLS or DAOOH and HRQoL in survivors at HRQoL-follow-up (615 and 1476 patients, respectively). There was substantial variability in outcomes, and predictions from the best fitted models were poor both internally and externally in the other trial dataset, which also showed inadequate calibration. Moderate associations were found when including non-survivors, although predictions remained uncertain and calibration inadequate.Conclusion: DAWOLS and DAOOH were poorly associated with HRQoL in adult survivors of severe or critical illness included in the COVID STEROID 2 and HOT-ICU trials.
AB - Background: Trials in critically ill patients increasingly focus on days alive without life support (DAWOLS) or days alive out of hospital (DAOOH) and health-related quality of life (HRQoL). DAWOLS and DAOOH convey more information than mortality and are simpler and faster to collect than HRQoL. However, whether these outcomes are associated with HRQoL is uncertain. We thus aimed to assess the associations between DAWOLS and DAOOH and long-term HRQoL.Methods: Secondary analysis of the COVID STEROID 2 trial including adults with COVID-19 and severe hypoxaemia and the Handling Oxygenation Targets in the Intensive Care Unit (HOT-ICU) trial including adult intensive care unit patients with acute hypoxaemic respiratory failure. Associations between DAWOLS and DAOOH at day 28 and 90 and long-term HRQoL (after 6 or 12 months) using the EuroQol 5-dimension 5-level survey (EQ VAS and EQ-5D-5L index values) were assessed using flexible models and evaluated using measures of fit and prediction adequacy in both datasets (comprising internal performance and external validation), non-parametric correlation coefficients and graphical presentations.Results: We found no strong associations between DAWOLS or DAOOH and HRQoL in survivors at HRQoL-follow-up (615 and 1476 patients, respectively). There was substantial variability in outcomes, and predictions from the best fitted models were poor both internally and externally in the other trial dataset, which also showed inadequate calibration. Moderate associations were found when including non-survivors, although predictions remained uncertain and calibration inadequate.Conclusion: DAWOLS and DAOOH were poorly associated with HRQoL in adult survivors of severe or critical illness included in the COVID STEROID 2 and HOT-ICU trials.
KW - critical care
KW - days alive out of hospital
KW - days alive without life support
KW - health-related quality of life
KW - outcome selection
KW - VENTILATOR-FREE DAYS
KW - FOLLOW-UP
KW - OUTCOMES
KW - TRIALS
U2 - 10.1111/aas.14231
DO - 10.1111/aas.14231
M3 - Journal article
C2 - 36915265
VL - 67
SP - 762
EP - 771
JO - Acta Anaesthesiologica Scandinavica
JF - Acta Anaesthesiologica Scandinavica
SN - 0001-5172
IS - 6
ER -
ID: 342055070