A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges
Research output: Contribution to journal › Review › Research › peer-review
Standard
A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers : Achievements and Future Challenges. / Kermanizadeh, Ali; Jacobsen, Nicklas Raun; Murphy, Fiona; Powell, Leagh; Parry, Lee; Zhang, Haiyuan; Møller, Peter.
In: Advanced Therapeutics, Vol. 4, No. 2, 2000186, 2021.Research output: Contribution to journal › Review › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers
T2 - Achievements and Future Challenges
AU - Kermanizadeh, Ali
AU - Jacobsen, Nicklas Raun
AU - Murphy, Fiona
AU - Powell, Leagh
AU - Parry, Lee
AU - Zhang, Haiyuan
AU - Møller, Peter
PY - 2021
Y1 - 2021
N2 - The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack of specific targeting, overt systemic toxicity and low efficacy. The use of nanomaterials show particular promise as candidates for cancer treatment due to their high surface to volume ratio and tuneable size, shape, and surface chemistry, which in combination, allow for improved tumor targeting and enhanced therapeutic efficacy. The scrutinization of the literature demonstrates the potential of nanosized carrier systems over traditional approaches (at the molecular level) for specific targeting of the tumors. Despite the great promise showing in preclinical studies, the number of nanomedicines reaching clinical testing is still very low. This review attempts to address this issue by using a weight of evidence approach to the different strategies for use of nanomedicines in combating cancer, as well as highlighting a number of areas that the field of nanomedicines is clearly lagging behind in, as compared to conventional drug discovery and development. It is hoped that the recommendations in this review will allow for better translation of nanomedicines reaching clinical trials.
AB - The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack of specific targeting, overt systemic toxicity and low efficacy. The use of nanomaterials show particular promise as candidates for cancer treatment due to their high surface to volume ratio and tuneable size, shape, and surface chemistry, which in combination, allow for improved tumor targeting and enhanced therapeutic efficacy. The scrutinization of the literature demonstrates the potential of nanosized carrier systems over traditional approaches (at the molecular level) for specific targeting of the tumors. Despite the great promise showing in preclinical studies, the number of nanomedicines reaching clinical testing is still very low. This review attempts to address this issue by using a weight of evidence approach to the different strategies for use of nanomedicines in combating cancer, as well as highlighting a number of areas that the field of nanomedicines is clearly lagging behind in, as compared to conventional drug discovery and development. It is hoped that the recommendations in this review will allow for better translation of nanomedicines reaching clinical trials.
KW - cancer
KW - inappropriate test models
KW - nanomedicines
KW - oncological nanomedicines
KW - targeting and therapy
KW - INDUCED PHOTODYNAMIC THERAPY
KW - CHEMO-PHOTOTHERMAL THERAPY
KW - IN-VIVO
KW - GOLD-NANORODS
KW - MAGNETIC-RESONANCE
KW - DRUG-DELIVERY
KW - HYBRID NANOCOMPOSITES
KW - SURFACE MODIFICATION
KW - NANOCARRIER SYSTEM
KW - COLORECTAL-CANCER
U2 - 10.1002/adtp.202000186
DO - 10.1002/adtp.202000186
M3 - Review
VL - 4
JO - Advanced Therapeutics
JF - Advanced Therapeutics
SN - 2366-3987
IS - 2
M1 - 2000186
ER -
ID: 252550048