A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges

Research output: Contribution to journalReviewpeer-review

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A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers : Achievements and Future Challenges. / Kermanizadeh, Ali; Jacobsen, Nicklas Raun; Murphy, Fiona; Powell, Leagh; Parry, Lee; Zhang, Haiyuan; Møller, Peter.

In: Advanced Therapeutics, Vol. 4, No. 2, 2000186, 2021.

Research output: Contribution to journalReviewpeer-review

Harvard

Kermanizadeh, A, Jacobsen, NR, Murphy, F, Powell, L, Parry, L, Zhang, H & Møller, P 2021, 'A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges', Advanced Therapeutics, vol. 4, no. 2, 2000186. https://doi.org/10.1002/adtp.202000186

APA

Kermanizadeh, A., Jacobsen, N. R., Murphy, F., Powell, L., Parry, L., Zhang, H., & Møller, P. (2021). A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges. Advanced Therapeutics, 4(2), [2000186]. https://doi.org/10.1002/adtp.202000186

Vancouver

Kermanizadeh A, Jacobsen NR, Murphy F, Powell L, Parry L, Zhang H et al. A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges. Advanced Therapeutics. 2021;4(2). 2000186. https://doi.org/10.1002/adtp.202000186

Author

Kermanizadeh, Ali ; Jacobsen, Nicklas Raun ; Murphy, Fiona ; Powell, Leagh ; Parry, Lee ; Zhang, Haiyuan ; Møller, Peter. / A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers : Achievements and Future Challenges. In: Advanced Therapeutics. 2021 ; Vol. 4, No. 2.

Bibtex

@article{fae11499601347d5ae70d49b6fba717d,
title = "A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers: Achievements and Future Challenges",
abstract = "The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack of specific targeting, overt systemic toxicity and low efficacy. The use of nanomaterials show particular promise as candidates for cancer treatment due to their high surface to volume ratio and tuneable size, shape, and surface chemistry, which in combination, allow for improved tumor targeting and enhanced therapeutic efficacy. The scrutinization of the literature demonstrates the potential of nanosized carrier systems over traditional approaches (at the molecular level) for specific targeting of the tumors. Despite the great promise showing in preclinical studies, the number of nanomedicines reaching clinical testing is still very low. This review attempts to address this issue by using a weight of evidence approach to the different strategies for use of nanomedicines in combating cancer, as well as highlighting a number of areas that the field of nanomedicines is clearly lagging behind in, as compared to conventional drug discovery and development. It is hoped that the recommendations in this review will allow for better translation of nanomedicines reaching clinical trials.",
keywords = "cancer, inappropriate test models, nanomedicines, oncological nanomedicines, targeting and therapy, INDUCED PHOTODYNAMIC THERAPY, CHEMO-PHOTOTHERMAL THERAPY, IN-VIVO, GOLD-NANORODS, MAGNETIC-RESONANCE, DRUG-DELIVERY, HYBRID NANOCOMPOSITES, SURFACE MODIFICATION, NANOCARRIER SYSTEM, COLORECTAL-CANCER",
author = "Ali Kermanizadeh and Jacobsen, {Nicklas Raun} and Fiona Murphy and Leagh Powell and Lee Parry and Haiyuan Zhang and Peter M{\o}ller",
year = "2021",
doi = "10.1002/adtp.202000186",
language = "English",
volume = "4",
journal = "Advanced Therapeutics",
issn = "2366-3987",
publisher = "Wiley-Blackwell",
number = "2",

}

RIS

TY - JOUR

T1 - A Review of the Current State of Nanomedicines for Targeting and Treatment of Cancers

T2 - Achievements and Future Challenges

AU - Kermanizadeh, Ali

AU - Jacobsen, Nicklas Raun

AU - Murphy, Fiona

AU - Powell, Leagh

AU - Parry, Lee

AU - Zhang, Haiyuan

AU - Møller, Peter

PY - 2021

Y1 - 2021

N2 - The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack of specific targeting, overt systemic toxicity and low efficacy. The use of nanomaterials show particular promise as candidates for cancer treatment due to their high surface to volume ratio and tuneable size, shape, and surface chemistry, which in combination, allow for improved tumor targeting and enhanced therapeutic efficacy. The scrutinization of the literature demonstrates the potential of nanosized carrier systems over traditional approaches (at the molecular level) for specific targeting of the tumors. Despite the great promise showing in preclinical studies, the number of nanomedicines reaching clinical testing is still very low. This review attempts to address this issue by using a weight of evidence approach to the different strategies for use of nanomedicines in combating cancer, as well as highlighting a number of areas that the field of nanomedicines is clearly lagging behind in, as compared to conventional drug discovery and development. It is hoped that the recommendations in this review will allow for better translation of nanomedicines reaching clinical trials.

AB - The design and utilization of nanomedicines offers great potential for treating various diseases including cancers. Current challenges with traditional cancer treatment strategies include but are not limited to lack of specific targeting, overt systemic toxicity and low efficacy. The use of nanomaterials show particular promise as candidates for cancer treatment due to their high surface to volume ratio and tuneable size, shape, and surface chemistry, which in combination, allow for improved tumor targeting and enhanced therapeutic efficacy. The scrutinization of the literature demonstrates the potential of nanosized carrier systems over traditional approaches (at the molecular level) for specific targeting of the tumors. Despite the great promise showing in preclinical studies, the number of nanomedicines reaching clinical testing is still very low. This review attempts to address this issue by using a weight of evidence approach to the different strategies for use of nanomedicines in combating cancer, as well as highlighting a number of areas that the field of nanomedicines is clearly lagging behind in, as compared to conventional drug discovery and development. It is hoped that the recommendations in this review will allow for better translation of nanomedicines reaching clinical trials.

KW - cancer

KW - inappropriate test models

KW - nanomedicines

KW - oncological nanomedicines

KW - targeting and therapy

KW - INDUCED PHOTODYNAMIC THERAPY

KW - CHEMO-PHOTOTHERMAL THERAPY

KW - IN-VIVO

KW - GOLD-NANORODS

KW - MAGNETIC-RESONANCE

KW - DRUG-DELIVERY

KW - HYBRID NANOCOMPOSITES

KW - SURFACE MODIFICATION

KW - NANOCARRIER SYSTEM

KW - COLORECTAL-CANCER

U2 - 10.1002/adtp.202000186

DO - 10.1002/adtp.202000186

M3 - Review

VL - 4

JO - Advanced Therapeutics

JF - Advanced Therapeutics

SN - 2366-3987

IS - 2

M1 - 2000186

ER -

ID: 252550048