Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly: a repeated measure analysis
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Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly : a repeated measure analysis. / Park, Hye Yin; Lim, Youn-Hee; Kim, Jin Hee; Bae, Sanghyuk; Oh, Se-Young; Hong, Yun-Chul.
In: Journal of Korean Medical Science, Vol. 27, No. 6, 2012, p. 653-660.Research output: Contribution to journal › Journal article › peer-review
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TY - JOUR
T1 - Association of serum 25-hydroxyvitamin D levels with markers for metabolic syndrome in the elderly
T2 - a repeated measure analysis
AU - Park, Hye Yin
AU - Lim, Youn-Hee
AU - Kim, Jin Hee
AU - Bae, Sanghyuk
AU - Oh, Se-Young
AU - Hong, Yun-Chul
PY - 2012
Y1 - 2012
N2 - The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.
AB - The purpose of current study was to investigate associations of serum 25-hydroxyvitamin D (OHVD) levels with markers for metabolic syndrome in elderly Koreans. We conducted a panel study on 301 individuals over 60 yr old in Seoul, Korea, and repeatedly measured serum OHVD, glucose, insulin, and lipid levels. Mixed effect model and generalized estimating equations were used to investigate relationships between serum OHVD levels with marker levels for metabolic syndrome and each of its categories. Of all subjects, 76.6% were vitamin D deficient (< 50 nM) and 16.9% were insufficient (< 75 nM). Inverse association was demonstrated between serum OHVD levels and insulin (P = 0.004), triglyceride (P = 0.023) and blood pressure (systolic blood pressure: P = 0.002; diastolic blood pressure: P < 0.001). Vitamin D deficiency was found to increase risk of 'hypertriglyceridemia' category of metabolic syndrome (odds ratio: 1.73, 95% confidence interval: 1.13-2.66). In conclusion, we found from our repeated measure analysis that decreasing serum OHVD levels are associated with increasing insulin resistance, increasing serum triglyceride levels and increasing blood pressure in elderly Koreans, and confirmed on the risk of 'hypertriglyceridemia' in vitamin D deficient subjects.
KW - Aged
KW - Aged, 80 and over
KW - Biomarkers/blood
KW - Blood Pressure
KW - Female
KW - Humans
KW - Hypertriglyceridemia/diagnosis
KW - Insulin/blood
KW - Insulin Resistance
KW - Male
KW - Metabolic Syndrome/diagnosis
KW - Middle Aged
KW - Odds Ratio
KW - Risk Factors
KW - Triglycerides/blood
KW - Vitamin D/analogs & derivatives
KW - Vitamin D Deficiency/complications
U2 - 10.3346/jkms.2012.27.6.653
DO - 10.3346/jkms.2012.27.6.653
M3 - Journal article
C2 - 22690097
VL - 27
SP - 653
EP - 660
JO - Journal of Korean Medical Science
JF - Journal of Korean Medical Science
SN - 1011-8934
IS - 6
ER -
ID: 230071780