High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders. / Lam, J.U.H.; Elfström, K M; Ejegod, D. M.; Pedersen, H.; Rygaard, C.; Rebolj, M.; Lynge, E; Juul, K. E.; Kjær, S. K.; Dillner, J.; Bonde, J.

In: B J C, Vol. 118, 2018, p. 138–144 .

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Lam, JUH, Elfström, KM, Ejegod, DM, Pedersen, H, Rygaard, C, Rebolj, M, Lynge, E, Juul, KE, Kjær, SK, Dillner, J & Bonde, J 2018, 'High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders', B J C, vol. 118, pp. 138–144 . https://doi.org/10.1038/bjc.2017.371

APA

Lam, J. U. H., Elfström, K. M., Ejegod, D. M., Pedersen, H., Rygaard, C., Rebolj, M., Lynge, E., Juul, K. E., Kjær, S. K., Dillner, J., & Bonde, J. (2018). High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders. B J C, 118, 138–144 . https://doi.org/10.1038/bjc.2017.371

Vancouver

Lam JUH, Elfström KM, Ejegod DM, Pedersen H, Rygaard C, Rebolj M et al. High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders. B J C. 2018;118:138–144 . https://doi.org/10.1038/bjc.2017.371

Author

Lam, J.U.H. ; Elfström, K M ; Ejegod, D. M. ; Pedersen, H. ; Rygaard, C. ; Rebolj, M. ; Lynge, E ; Juul, K. E. ; Kjær, S. K. ; Dillner, J. ; Bonde, J. / High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders. In: B J C. 2018 ; Vol. 118. pp. 138–144 .

Bibtex

@article{9449b41f2d8d4948958cf2276b2eb96c,
title = "High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders",
abstract = "BACKGROUND: Self-sampling for human papillomavirus (HPV) offered to women who do not participate in cervical cancer screening is an increasingly popular method to increase screening coverage. The rationale behind self-sampling is that unscreened women harbour a high proportion of undetected precancer lesions. Here, we compare the cervical intraepithelial neoplasia grade 2 or worse (⩾CIN2) detection rate between non-attenders who participated in self-sampling and women attending routine screening.METHODS: A total of 23 632 women who were qualified as non-attenders in the Copenhagen Region were invited for HPV-based self-sampling. Of these, 4824 women returned a self-sample, and HPV-positive women were referred for cytology and HPV co-testing as follow-up. The entire cohort and a reference cohort (3347 routinely screened women) were followed for histopathology confirmed ⩾CIN2. Odds ratio (OR) and the relative positive predictive value of ⩾CIN2 detection between the two populations were estimated.RESULTS: Women participating in self-sampling had a higher ⩾CIN2 detection than women undergoing routine cytology-based screening (OR=1.83, 95% CI: 1.21-2.77) and a similar detection as routinely screened women tested with cytology and HPV testing (OR=1.03, 95% CI: 0.75-1.40). The positive predictive value for ⩾CIN2 was higher in screening non-attenders than in routinely HPV- and cytology-screened screened women (36.5% vs 25.6%, respectively).CONCLUSIONS: Self-sampling offered to non-attenders showed higher detection rates for ⩾CIN2 than routine cytology-based screening, and similar detection rates as HPV and cytology co-testing. This reinforces the importance of self-sampling for screening non-attenders in organised cervical cancer screening.British Journal of Cancer advance online publication, 14 November 2017; doi:10.1038/bjc.2017.371 www.bjcancer.com.",
keywords = "Journal Article",
author = "J.U.H. Lam and Elfstr{\"o}m, {K M} and Ejegod, {D. M.} and H. Pedersen and C. Rygaard and M. Rebolj and E Lynge and Juul, {K. E.} and Kj{\ae}r, {S. K.} and J. Dillner and J. Bonde",
year = "2018",
doi = "10.1038/bjc.2017.371",
language = "English",
volume = "118",
pages = "138–144 ",
journal = "The British journal of cancer. Supplement",
issn = "0007-0920",
publisher = "nature publishing group",

}

RIS

TY - JOUR

T1 - High-grade cervical intraepithelial neoplasia in human papillomavirus self-sampling of screening non-attenders

AU - Lam, J.U.H.

AU - Elfström, K M

AU - Ejegod, D. M.

AU - Pedersen, H.

AU - Rygaard, C.

AU - Rebolj, M.

AU - Lynge, E

AU - Juul, K. E.

AU - Kjær, S. K.

AU - Dillner, J.

AU - Bonde, J.

PY - 2018

Y1 - 2018

N2 - BACKGROUND: Self-sampling for human papillomavirus (HPV) offered to women who do not participate in cervical cancer screening is an increasingly popular method to increase screening coverage. The rationale behind self-sampling is that unscreened women harbour a high proportion of undetected precancer lesions. Here, we compare the cervical intraepithelial neoplasia grade 2 or worse (⩾CIN2) detection rate between non-attenders who participated in self-sampling and women attending routine screening.METHODS: A total of 23 632 women who were qualified as non-attenders in the Copenhagen Region were invited for HPV-based self-sampling. Of these, 4824 women returned a self-sample, and HPV-positive women were referred for cytology and HPV co-testing as follow-up. The entire cohort and a reference cohort (3347 routinely screened women) were followed for histopathology confirmed ⩾CIN2. Odds ratio (OR) and the relative positive predictive value of ⩾CIN2 detection between the two populations were estimated.RESULTS: Women participating in self-sampling had a higher ⩾CIN2 detection than women undergoing routine cytology-based screening (OR=1.83, 95% CI: 1.21-2.77) and a similar detection as routinely screened women tested with cytology and HPV testing (OR=1.03, 95% CI: 0.75-1.40). The positive predictive value for ⩾CIN2 was higher in screening non-attenders than in routinely HPV- and cytology-screened screened women (36.5% vs 25.6%, respectively).CONCLUSIONS: Self-sampling offered to non-attenders showed higher detection rates for ⩾CIN2 than routine cytology-based screening, and similar detection rates as HPV and cytology co-testing. This reinforces the importance of self-sampling for screening non-attenders in organised cervical cancer screening.British Journal of Cancer advance online publication, 14 November 2017; doi:10.1038/bjc.2017.371 www.bjcancer.com.

AB - BACKGROUND: Self-sampling for human papillomavirus (HPV) offered to women who do not participate in cervical cancer screening is an increasingly popular method to increase screening coverage. The rationale behind self-sampling is that unscreened women harbour a high proportion of undetected precancer lesions. Here, we compare the cervical intraepithelial neoplasia grade 2 or worse (⩾CIN2) detection rate between non-attenders who participated in self-sampling and women attending routine screening.METHODS: A total of 23 632 women who were qualified as non-attenders in the Copenhagen Region were invited for HPV-based self-sampling. Of these, 4824 women returned a self-sample, and HPV-positive women were referred for cytology and HPV co-testing as follow-up. The entire cohort and a reference cohort (3347 routinely screened women) were followed for histopathology confirmed ⩾CIN2. Odds ratio (OR) and the relative positive predictive value of ⩾CIN2 detection between the two populations were estimated.RESULTS: Women participating in self-sampling had a higher ⩾CIN2 detection than women undergoing routine cytology-based screening (OR=1.83, 95% CI: 1.21-2.77) and a similar detection as routinely screened women tested with cytology and HPV testing (OR=1.03, 95% CI: 0.75-1.40). The positive predictive value for ⩾CIN2 was higher in screening non-attenders than in routinely HPV- and cytology-screened screened women (36.5% vs 25.6%, respectively).CONCLUSIONS: Self-sampling offered to non-attenders showed higher detection rates for ⩾CIN2 than routine cytology-based screening, and similar detection rates as HPV and cytology co-testing. This reinforces the importance of self-sampling for screening non-attenders in organised cervical cancer screening.British Journal of Cancer advance online publication, 14 November 2017; doi:10.1038/bjc.2017.371 www.bjcancer.com.

KW - Journal Article

U2 - 10.1038/bjc.2017.371

DO - 10.1038/bjc.2017.371

M3 - Journal article

C2 - 29136403

VL - 118

SP - 138

EP - 144

JO - The British journal of cancer. Supplement

JF - The British journal of cancer. Supplement

SN - 0007-0920

ER -

ID: 185945587