Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort
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Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort. / Taj, Tahir; Chen, Jie; Rodopoulou, Sophia; Strak, Maciej; de Hoogh, Kees; Poulsen, Aslak Harbo; Andersen, Zorana J; Bellander, Tom; Brandt, Jørgen; Zitt, Emanuel; Fecht, Daniela; Forastiere, Francesco; Gulliver, John; Hertel, Ole; Hoffmann, Barbara; Hvidtfeldt, Ulla Arthur; Jørgensen, Jeanette T; Katsouyanni, Klea; Ketzel, Matthias; Lager, Anton; Leander, Karin; Liu, Shuo; Ljungman, Petter; Severi, Gianluca; Besson, Caroline; Magnusson, Patrik K E; Nagel, Gabriele; Pershagen, Göran; Peters, Annette; Rizzuto, Debora; Samoli, Evangelia; Sørensen, Mette; Stafoggia, Massimo; Tjønneland, Anne; Weinmayr, Gudrun; Wolf, Kathrin; Brunekreef, Bert; Hoek, Gerard; Raaschou-Nielsen, Ole.
In: Environmental Pollution, Vol. 343, 123097, 2024.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long-term exposure to ambient air pollution and risk of leukemia and lymphoma in a pooled European cohort
AU - Taj, Tahir
AU - Chen, Jie
AU - Rodopoulou, Sophia
AU - Strak, Maciej
AU - de Hoogh, Kees
AU - Poulsen, Aslak Harbo
AU - Andersen, Zorana J
AU - Bellander, Tom
AU - Brandt, Jørgen
AU - Zitt, Emanuel
AU - Fecht, Daniela
AU - Forastiere, Francesco
AU - Gulliver, John
AU - Hertel, Ole
AU - Hoffmann, Barbara
AU - Hvidtfeldt, Ulla Arthur
AU - Jørgensen, Jeanette T
AU - Katsouyanni, Klea
AU - Ketzel, Matthias
AU - Lager, Anton
AU - Leander, Karin
AU - Liu, Shuo
AU - Ljungman, Petter
AU - Severi, Gianluca
AU - Besson, Caroline
AU - Magnusson, Patrik K E
AU - Nagel, Gabriele
AU - Pershagen, Göran
AU - Peters, Annette
AU - Rizzuto, Debora
AU - Samoli, Evangelia
AU - Sørensen, Mette
AU - Stafoggia, Massimo
AU - Tjønneland, Anne
AU - Weinmayr, Gudrun
AU - Wolf, Kathrin
AU - Brunekreef, Bert
AU - Hoek, Gerard
AU - Raaschou-Nielsen, Ole
N1 - Copyright © 2023 Elsevier Ltd. All rights reserved.
PY - 2024
Y1 - 2024
N2 - Leukemia and lymphoma are the two most common forms of hematologic malignancy, and their etiology is largely unknown. Pathophysiological mechanisms suggest a possible association with air pollution, but little empirical evidence is available. We aimed to investigate the association between long-term residential exposure to outdoor air pollution and risk of leukemia and lymphoma. We pooled data from four cohorts from three European countries as part of the "Effects of Low-level Air Pollution: a Study in Europe" (ELAPSE) collaboration. We used Europe-wide land use regression models to assess annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone (O3) at residences. We also estimated concentrations of PM2.5 elemental components: copper (Cu), iron (Fe), zinc (Zn); sulfur (S); nickel (Ni), vanadium (V), silicon (Si) and potassium (K). We applied Cox proportional hazards models to investigate the associations. Among the study population of 247,436 individuals, 760 leukemia and 1122 lymphoma cases were diagnosed during 4,656,140 person-years of follow-up. The results showed a leukemia hazard ratio (HR) of 1.13 (95% confidence intervals [CI]: 1.01-1.26) per 10 μg/m3 NO2, which was robust in two-pollutant models and consistent across the four cohorts and according to smoking status. Sex-specific analyses suggested that this association was confined to the male population. Further, the results showed increased lymphoma HRs for PM2.5 (HR = 1.16; 95% CI: 1.02-1.34) and potassium content of PM2.5, which were consistent in two-pollutant models and according to sex. Our results suggest that air pollution at the residence may be associated with adult leukemia and lymphoma.
AB - Leukemia and lymphoma are the two most common forms of hematologic malignancy, and their etiology is largely unknown. Pathophysiological mechanisms suggest a possible association with air pollution, but little empirical evidence is available. We aimed to investigate the association between long-term residential exposure to outdoor air pollution and risk of leukemia and lymphoma. We pooled data from four cohorts from three European countries as part of the "Effects of Low-level Air Pollution: a Study in Europe" (ELAPSE) collaboration. We used Europe-wide land use regression models to assess annual mean concentrations of fine particulate matter (PM2.5), nitrogen dioxide (NO2), black carbon (BC) and ozone (O3) at residences. We also estimated concentrations of PM2.5 elemental components: copper (Cu), iron (Fe), zinc (Zn); sulfur (S); nickel (Ni), vanadium (V), silicon (Si) and potassium (K). We applied Cox proportional hazards models to investigate the associations. Among the study population of 247,436 individuals, 760 leukemia and 1122 lymphoma cases were diagnosed during 4,656,140 person-years of follow-up. The results showed a leukemia hazard ratio (HR) of 1.13 (95% confidence intervals [CI]: 1.01-1.26) per 10 μg/m3 NO2, which was robust in two-pollutant models and consistent across the four cohorts and according to smoking status. Sex-specific analyses suggested that this association was confined to the male population. Further, the results showed increased lymphoma HRs for PM2.5 (HR = 1.16; 95% CI: 1.02-1.34) and potassium content of PM2.5, which were consistent in two-pollutant models and according to sex. Our results suggest that air pollution at the residence may be associated with adult leukemia and lymphoma.
U2 - 10.1016/j.envpol.2023.123097
DO - 10.1016/j.envpol.2023.123097
M3 - Journal article
C2 - 38065336
VL - 343
JO - Environmental Pollution
JF - Environmental Pollution
SN - 0269-7491
M1 - 123097
ER -
ID: 380053360