Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project

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Long-term exposure to low-level air pollution and incidence of asthma : the ELAPSE project. / Liu, Shuo; Jorgensen, Jeanette Therming; Ljungman, Petter; Pershagen, Goran; Bellander, Tom; Leander, Karin; Magnusson, Patrik K. E.; Rizzuto, Debora; Hvidtfeldt, Ulla A.; Nielsen, Ole Raaschou; Wolf, Kathrin; Hoffmann, Barbara; Brnekree, Bert; Strak, Maciej; Chen, Jie; Mehta, Amar; Atkinson, Richard W.; Bauwelrick, Mariska; Varraso, Raphaelle; Boutron-Ruault, Marie-Christine; Brandt, Jorgen; Cesaroni, Giulia; Forastiere, Francesco; Fecht, Daniela; Gulliver, John; Herte, Ole; de Hoogh, Kees; Janssen, Nicole A. H.; Katsouyanni, Klea; Ketzel, Matthias; Klompmaker, Jochem O.; Nagel, Gabriele; Oftedal, Bente; Peters, Annette; Tjonneland, Anne; Rodopoulou, Sophia P.; Samoli, Evangelia; Kristoffersen, Doris Tove; Sigsgaard, Torben; Stafoggia, Massimo; Vienneau, Danielle; Weinmayr, Gudrun; Hoek, Gerard; Andersen, Zorana Jovanovic.

In: European Respiratory Journal, Vol. 57, No. 6, 2003099, 2021.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Liu, S, Jorgensen, JT, Ljungman, P, Pershagen, G, Bellander, T, Leander, K, Magnusson, PKE, Rizzuto, D, Hvidtfeldt, UA, Nielsen, OR, Wolf, K, Hoffmann, B, Brnekree, B, Strak, M, Chen, J, Mehta, A, Atkinson, RW, Bauwelrick, M, Varraso, R, Boutron-Ruault, M-C, Brandt, J, Cesaroni, G, Forastiere, F, Fecht, D, Gulliver, J, Herte, O, de Hoogh, K, Janssen, NAH, Katsouyanni, K, Ketzel, M, Klompmaker, JO, Nagel, G, Oftedal, B, Peters, A, Tjonneland, A, Rodopoulou, SP, Samoli, E, Kristoffersen, DT, Sigsgaard, T, Stafoggia, M, Vienneau, D, Weinmayr, G, Hoek, G & Andersen, ZJ 2021, 'Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project', European Respiratory Journal, vol. 57, no. 6, 2003099. https://doi.org/10.1183/13993003.030992020

APA

Liu, S., Jorgensen, J. T., Ljungman, P., Pershagen, G., Bellander, T., Leander, K., Magnusson, P. K. E., Rizzuto, D., Hvidtfeldt, U. A., Nielsen, O. R., Wolf, K., Hoffmann, B., Brnekree, B., Strak, M., Chen, J., Mehta, A., Atkinson, R. W., Bauwelrick, M., Varraso, R., ... Andersen, Z. J. (2021). Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project. European Respiratory Journal, 57(6), [2003099]. https://doi.org/10.1183/13993003.030992020

Vancouver

Liu S, Jorgensen JT, Ljungman P, Pershagen G, Bellander T, Leander K et al. Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project. European Respiratory Journal. 2021;57(6). 2003099. https://doi.org/10.1183/13993003.030992020

Author

Liu, Shuo ; Jorgensen, Jeanette Therming ; Ljungman, Petter ; Pershagen, Goran ; Bellander, Tom ; Leander, Karin ; Magnusson, Patrik K. E. ; Rizzuto, Debora ; Hvidtfeldt, Ulla A. ; Nielsen, Ole Raaschou ; Wolf, Kathrin ; Hoffmann, Barbara ; Brnekree, Bert ; Strak, Maciej ; Chen, Jie ; Mehta, Amar ; Atkinson, Richard W. ; Bauwelrick, Mariska ; Varraso, Raphaelle ; Boutron-Ruault, Marie-Christine ; Brandt, Jorgen ; Cesaroni, Giulia ; Forastiere, Francesco ; Fecht, Daniela ; Gulliver, John ; Herte, Ole ; de Hoogh, Kees ; Janssen, Nicole A. H. ; Katsouyanni, Klea ; Ketzel, Matthias ; Klompmaker, Jochem O. ; Nagel, Gabriele ; Oftedal, Bente ; Peters, Annette ; Tjonneland, Anne ; Rodopoulou, Sophia P. ; Samoli, Evangelia ; Kristoffersen, Doris Tove ; Sigsgaard, Torben ; Stafoggia, Massimo ; Vienneau, Danielle ; Weinmayr, Gudrun ; Hoek, Gerard ; Andersen, Zorana Jovanovic. / Long-term exposure to low-level air pollution and incidence of asthma : the ELAPSE project. In: European Respiratory Journal. 2021 ; Vol. 57, No. 6.

Bibtex

@article{ee741758efad424e8b43924311c94892,
title = "Long-term exposure to low-level air pollution and incidence of asthma: the ELAPSE project",
abstract = "Background: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameterMethods: We pooled data from three cohorts in Denmark and Sweden with information on asthma hospital diagnoses. The average concentrations of air pollutants in 2010 were modelled by hybrid land-use regression models at participants' baseline residential addresses. Associations of air pollution exposures with asthma incidence were explored with Cox proportional hazard models, adjusting for potential confounders.Results: Of 98326 participants, 1965 developed asthma during a mean follow-up of 16.6 years. We observed associations in fully adjusted models with hazard ratios of 1.22 (95% CI 1.04-1.43) per 5 mu g.m(-3) for PM2.5, 1.17 (95% CI 1.10-1.25) per 10 mu g.m(-3) for NO2 and 1.15 (95% CI 1.08-1.23) per 0.5 x 10(-5) m(-1) for BC. Hazard ratios were larger in cohort subsets with exposure levels below the European Union and US limit values and possibly World Health Organization guidelines for PM2.5 and NO2. NO 2 and BC estimates remained unchanged in two-pollutant models with PM2.5, whereas PM2.5 estimates were attenuated to unity. The concentration-response curves showed no evidence of a threshold.Conclusions: Long-term exposure to air pollution, especially from fossil fuel combustion sources such as motorised traffic, was associated with adult-onset asthma, even at levels below the current limit values.",
keywords = "ADULT-ONSET ASTHMA, EUROPEAN COHORTS, GLOBAL BURDEN, FOLLOW-UP, DISEASE, MORTALITY, HEALTH, NO2, PM2.5, SCALE",
author = "Shuo Liu and Jorgensen, {Jeanette Therming} and Petter Ljungman and Goran Pershagen and Tom Bellander and Karin Leander and Magnusson, {Patrik K. E.} and Debora Rizzuto and Hvidtfeldt, {Ulla A.} and Nielsen, {Ole Raaschou} and Kathrin Wolf and Barbara Hoffmann and Bert Brnekree and Maciej Strak and Jie Chen and Amar Mehta and Atkinson, {Richard W.} and Mariska Bauwelrick and Raphaelle Varraso and Marie-Christine Boutron-Ruault and Jorgen Brandt and Giulia Cesaroni and Francesco Forastiere and Daniela Fecht and John Gulliver and Ole Herte and {de Hoogh}, Kees and Janssen, {Nicole A. H.} and Klea Katsouyanni and Matthias Ketzel and Klompmaker, {Jochem O.} and Gabriele Nagel and Bente Oftedal and Annette Peters and Anne Tjonneland and Rodopoulou, {Sophia P.} and Evangelia Samoli and Kristoffersen, {Doris Tove} and Torben Sigsgaard and Massimo Stafoggia and Danielle Vienneau and Gudrun Weinmayr and Gerard Hoek and Andersen, {Zorana Jovanovic}",
year = "2021",
doi = "10.1183/13993003.030992020",
language = "English",
volume = "57",
journal = "The European Respiratory Journal",
issn = "0903-1936",
publisher = "European Respiratory Society",
number = "6",

}

RIS

TY - JOUR

T1 - Long-term exposure to low-level air pollution and incidence of asthma

T2 - the ELAPSE project

AU - Liu, Shuo

AU - Jorgensen, Jeanette Therming

AU - Ljungman, Petter

AU - Pershagen, Goran

AU - Bellander, Tom

AU - Leander, Karin

AU - Magnusson, Patrik K. E.

AU - Rizzuto, Debora

AU - Hvidtfeldt, Ulla A.

AU - Nielsen, Ole Raaschou

AU - Wolf, Kathrin

AU - Hoffmann, Barbara

AU - Brnekree, Bert

AU - Strak, Maciej

AU - Chen, Jie

AU - Mehta, Amar

AU - Atkinson, Richard W.

AU - Bauwelrick, Mariska

AU - Varraso, Raphaelle

AU - Boutron-Ruault, Marie-Christine

AU - Brandt, Jorgen

AU - Cesaroni, Giulia

AU - Forastiere, Francesco

AU - Fecht, Daniela

AU - Gulliver, John

AU - Herte, Ole

AU - de Hoogh, Kees

AU - Janssen, Nicole A. H.

AU - Katsouyanni, Klea

AU - Ketzel, Matthias

AU - Klompmaker, Jochem O.

AU - Nagel, Gabriele

AU - Oftedal, Bente

AU - Peters, Annette

AU - Tjonneland, Anne

AU - Rodopoulou, Sophia P.

AU - Samoli, Evangelia

AU - Kristoffersen, Doris Tove

AU - Sigsgaard, Torben

AU - Stafoggia, Massimo

AU - Vienneau, Danielle

AU - Weinmayr, Gudrun

AU - Hoek, Gerard

AU - Andersen, Zorana Jovanovic

PY - 2021

Y1 - 2021

N2 - Background: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameterMethods: We pooled data from three cohorts in Denmark and Sweden with information on asthma hospital diagnoses. The average concentrations of air pollutants in 2010 were modelled by hybrid land-use regression models at participants' baseline residential addresses. Associations of air pollution exposures with asthma incidence were explored with Cox proportional hazard models, adjusting for potential confounders.Results: Of 98326 participants, 1965 developed asthma during a mean follow-up of 16.6 years. We observed associations in fully adjusted models with hazard ratios of 1.22 (95% CI 1.04-1.43) per 5 mu g.m(-3) for PM2.5, 1.17 (95% CI 1.10-1.25) per 10 mu g.m(-3) for NO2 and 1.15 (95% CI 1.08-1.23) per 0.5 x 10(-5) m(-1) for BC. Hazard ratios were larger in cohort subsets with exposure levels below the European Union and US limit values and possibly World Health Organization guidelines for PM2.5 and NO2. NO 2 and BC estimates remained unchanged in two-pollutant models with PM2.5, whereas PM2.5 estimates were attenuated to unity. The concentration-response curves showed no evidence of a threshold.Conclusions: Long-term exposure to air pollution, especially from fossil fuel combustion sources such as motorised traffic, was associated with adult-onset asthma, even at levels below the current limit values.

AB - Background: Long-term exposure to ambient air pollution has been linked to childhood-onset asthma, although evidence is still insufficient. Within the multicentre project Effects of Low-Level Air Pollution: A Study in Europe (ELAPSE), we examined the associations of long-term exposures to particulate matter with a diameterMethods: We pooled data from three cohorts in Denmark and Sweden with information on asthma hospital diagnoses. The average concentrations of air pollutants in 2010 were modelled by hybrid land-use regression models at participants' baseline residential addresses. Associations of air pollution exposures with asthma incidence were explored with Cox proportional hazard models, adjusting for potential confounders.Results: Of 98326 participants, 1965 developed asthma during a mean follow-up of 16.6 years. We observed associations in fully adjusted models with hazard ratios of 1.22 (95% CI 1.04-1.43) per 5 mu g.m(-3) for PM2.5, 1.17 (95% CI 1.10-1.25) per 10 mu g.m(-3) for NO2 and 1.15 (95% CI 1.08-1.23) per 0.5 x 10(-5) m(-1) for BC. Hazard ratios were larger in cohort subsets with exposure levels below the European Union and US limit values and possibly World Health Organization guidelines for PM2.5 and NO2. NO 2 and BC estimates remained unchanged in two-pollutant models with PM2.5, whereas PM2.5 estimates were attenuated to unity. The concentration-response curves showed no evidence of a threshold.Conclusions: Long-term exposure to air pollution, especially from fossil fuel combustion sources such as motorised traffic, was associated with adult-onset asthma, even at levels below the current limit values.

KW - ADULT-ONSET ASTHMA

KW - EUROPEAN COHORTS

KW - GLOBAL BURDEN

KW - FOLLOW-UP

KW - DISEASE

KW - MORTALITY

KW - HEALTH

KW - NO2

KW - PM2.5

KW - SCALE

U2 - 10.1183/13993003.030992020

DO - 10.1183/13993003.030992020

M3 - Journal article

C2 - 33303534

VL - 57

JO - The European Respiratory Journal

JF - The European Respiratory Journal

SN - 0903-1936

IS - 6

M1 - 2003099

ER -

ID: 272071965