Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts
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Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts. / Wolf, Kathrin; Stafoggia, Massimo; Cesaroni, Giulia; Andersen, Zorana Jovanovic; Beelen, Rob; Galassi, Claudia; Hennig, Frauke; Migliore, Enrica; Penell, Johanna; Ricceri, Fulvio; Sørensen, Mette; Turunen, Anu W; Hampel, Regina; Hoffmann, Barbara; Kälsch, Hagen; Laatikainen, Tiina; Pershagen, Göran; Raaschou-Nielsen, Ole; Sacerdote, Carlotta; Vineis, Paolo; Badaloni, Chiara; Cyrys, Josef; de Hoogh, Kees; Eriksen, Kirsten T; Jedynska, Aleksandra; Keuken, Menno; Kooter, Ingeborg; Lanki, Timo; Ranzi, Andrea; Sugiri, Dorothea; Tsai, Ming-Yi; Wang, Meng; Hoek, Gerard; Brunekreef, Bert; Peters, Annette; Forastiere, Francesco.
In: Epidemiology (Cambridge, Mass.), Vol. 26, No. 4, 07.2015, p. 565–574.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Long-term Exposure to Particulate Matter Constituents and the Incidence of Coronary Events in 11 European Cohorts
AU - Wolf, Kathrin
AU - Stafoggia, Massimo
AU - Cesaroni, Giulia
AU - Andersen, Zorana Jovanovic
AU - Beelen, Rob
AU - Galassi, Claudia
AU - Hennig, Frauke
AU - Migliore, Enrica
AU - Penell, Johanna
AU - Ricceri, Fulvio
AU - Sørensen, Mette
AU - Turunen, Anu W
AU - Hampel, Regina
AU - Hoffmann, Barbara
AU - Kälsch, Hagen
AU - Laatikainen, Tiina
AU - Pershagen, Göran
AU - Raaschou-Nielsen, Ole
AU - Sacerdote, Carlotta
AU - Vineis, Paolo
AU - Badaloni, Chiara
AU - Cyrys, Josef
AU - de Hoogh, Kees
AU - Eriksen, Kirsten T
AU - Jedynska, Aleksandra
AU - Keuken, Menno
AU - Kooter, Ingeborg
AU - Lanki, Timo
AU - Ranzi, Andrea
AU - Sugiri, Dorothea
AU - Tsai, Ming-Yi
AU - Wang, Meng
AU - Hoek, Gerard
AU - Brunekreef, Bert
AU - Peters, Annette
AU - Forastiere, Francesco
PY - 2015/7
Y1 - 2015/7
N2 - BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM. This study examined the association of residential long-term exposure to PM components with incident coronary events.METHODS: Eleven cohorts from Finland, Sweden, Denmark, Germany, and Italy participated in this analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM < 10 μm (PM10), PM < 2.5 μm (PM2.5), and a priori selected constituents (copper, iron, nickel, potassium, silicon, sulfur, vanadium, and zinc) were estimated with land-use regression models. We used Cox proportional hazard models adjusted for a common set of confounders to estimate cohort-specific component effects with and without including PM mass, and random effects meta-analyses to pool cohort-specific results.RESULTS: A 100 ng/m³ increase in PM10 K and a 50 ng/m³ increase in PM2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM10 Si and PM2.5 Fe were also elevated. All other PM constituents indicated a positive association with coronary events. When additionally adjusting for PM mass, the estimates decreased except for K.CONCLUSIONS: This multicenter study of 11 European cohorts pointed to an association between long-term exposure to PM constituents and coronary events, especially for indicators of road dust.
AB - BACKGROUND: Long-term exposure to particulate matter (PM) has been associated with increased cardiovascular morbidity and mortality but little is known about the role of the chemical composition of PM. This study examined the association of residential long-term exposure to PM components with incident coronary events.METHODS: Eleven cohorts from Finland, Sweden, Denmark, Germany, and Italy participated in this analysis. 5,157 incident coronary events were identified within 100,166 persons followed on average for 11.5 years. Long-term residential concentrations of PM < 10 μm (PM10), PM < 2.5 μm (PM2.5), and a priori selected constituents (copper, iron, nickel, potassium, silicon, sulfur, vanadium, and zinc) were estimated with land-use regression models. We used Cox proportional hazard models adjusted for a common set of confounders to estimate cohort-specific component effects with and without including PM mass, and random effects meta-analyses to pool cohort-specific results.RESULTS: A 100 ng/m³ increase in PM10 K and a 50 ng/m³ increase in PM2.5 K were associated with a 6% (hazard ratio and 95% confidence interval: 1.06 [1.01, 1.12]) and 18% (1.18 [1.06, 1.32]) increase in coronary events. Estimates for PM10 Si and PM2.5 Fe were also elevated. All other PM constituents indicated a positive association with coronary events. When additionally adjusting for PM mass, the estimates decreased except for K.CONCLUSIONS: This multicenter study of 11 European cohorts pointed to an association between long-term exposure to PM constituents and coronary events, especially for indicators of road dust.
U2 - 10.1097/EDE.0000000000000300
DO - 10.1097/EDE.0000000000000300
M3 - Journal article
C2 - 25978793
VL - 26
SP - 565
EP - 574
JO - Epidemiology
JF - Epidemiology
SN - 1044-3983
IS - 4
ER -
ID: 138143139