Mild Anemia and Risk for All-Cause, Cardiovascular and Cancer Deaths in Apparently Healthy Elderly Koreans
Research output: Contribution to journal › Journal article › Research › peer-review
Standard
Mild Anemia and Risk for All-Cause, Cardiovascular and Cancer Deaths in Apparently Healthy Elderly Koreans. / Han, Sil Vi; Park, Minseon; Kwon, Young-Min; Yoon, Hyung-Jin; Chang, Yoosoo; Kim, Ho; Lim, Youn-Hee; Kim, Su Gyeong; Ko, Ahryoung.
In: Korean Journal of Family Medicine, Vol. 40, No. 3, 2019, p. 151-158.Research output: Contribution to journal › Journal article › Research › peer-review
Harvard
APA
Vancouver
Author
Bibtex
}
RIS
TY - JOUR
T1 - Mild Anemia and Risk for All-Cause, Cardiovascular and Cancer Deaths in Apparently Healthy Elderly Koreans
AU - Han, Sil Vi
AU - Park, Minseon
AU - Kwon, Young-Min
AU - Yoon, Hyung-Jin
AU - Chang, Yoosoo
AU - Kim, Ho
AU - Lim, Youn-Hee
AU - Kim, Su Gyeong
AU - Ko, Ahryoung
PY - 2019
Y1 - 2019
N2 - BACKGROUND: Being common, mild anemia is sometimes considered a mere consequence of aging; however, aging alone is unlikely to lead to anemia. Therefore, this study aimed to investigate the association between mild anemia and total mortality and cause-specific mortality in apparently healthy elderly subjects.METHODS: A retrospective cohort study was conducted on 10,114 apparently healthy elderly individuals who underwent cancer screening and routine medical check-ups at one Health Promotion Center between May 1995 and December 2007. We defined mild anemia as a hemoglobin concentration between 10.0 g/dL and 11.9 g/dL in women and between 10.0 g/dL and 12.9 g/dL in men. We assessed the relationship between the overall, cardiovascular (CV), and cancer mortality and mild anemia using Cox proportional hazard models.RESULTS: Mild anemia was present in 143 men (3.1%) and 246 women (6.1%). During an average follow-up of 7.6 years, 495 deaths occurred, including 121 CV and 225 cancer deaths. After adjustments, mild anemia was associated with a 128% increase in the risk of all-cause mortality hazard ratio (HR, 2.28; 95% confidence interval [CI], 1.54- 3.37) in men and cancer-related mortality (HR, 2.25; 95% CI, 1.22-4.13), particularly lung cancer (HR, 2.70; 95% CI, 1.03-7.08) in men, but not in women. In the subgroup analyses based on smoking status, obesity, and age, the associations were more prominent in never or former smoker groups and the older group.CONCLUSION: The present study shows that overall and cancer-related mortality was associated with mild anemia in elderly men. Future prospective studies are needed to consolidate our findings.
AB - BACKGROUND: Being common, mild anemia is sometimes considered a mere consequence of aging; however, aging alone is unlikely to lead to anemia. Therefore, this study aimed to investigate the association between mild anemia and total mortality and cause-specific mortality in apparently healthy elderly subjects.METHODS: A retrospective cohort study was conducted on 10,114 apparently healthy elderly individuals who underwent cancer screening and routine medical check-ups at one Health Promotion Center between May 1995 and December 2007. We defined mild anemia as a hemoglobin concentration between 10.0 g/dL and 11.9 g/dL in women and between 10.0 g/dL and 12.9 g/dL in men. We assessed the relationship between the overall, cardiovascular (CV), and cancer mortality and mild anemia using Cox proportional hazard models.RESULTS: Mild anemia was present in 143 men (3.1%) and 246 women (6.1%). During an average follow-up of 7.6 years, 495 deaths occurred, including 121 CV and 225 cancer deaths. After adjustments, mild anemia was associated with a 128% increase in the risk of all-cause mortality hazard ratio (HR, 2.28; 95% confidence interval [CI], 1.54- 3.37) in men and cancer-related mortality (HR, 2.25; 95% CI, 1.22-4.13), particularly lung cancer (HR, 2.70; 95% CI, 1.03-7.08) in men, but not in women. In the subgroup analyses based on smoking status, obesity, and age, the associations were more prominent in never or former smoker groups and the older group.CONCLUSION: The present study shows that overall and cancer-related mortality was associated with mild anemia in elderly men. Future prospective studies are needed to consolidate our findings.
U2 - 10.4082/kjfm.17.0089
DO - 10.4082/kjfm.17.0089
M3 - Journal article
C2 - 30650952
VL - 40
SP - 151
EP - 158
JO - Korean Journal of Family Medicine
JF - Korean Journal of Family Medicine
SN - 2005-6443
IS - 3
ER -
ID: 230065730