Non-Linear Concentration-Response Relationships between Ambient Ozone and Daily Mortality
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Non-Linear Concentration-Response Relationships between Ambient Ozone and Daily Mortality. / Bae, Sanghyuk; Lim, Youn-Hee; Kashima, Saori; Yorifuji, Takashi; Honda, Yasushi; Kim, Ho; Hong, Yun-Chul.
In: PLoS ONE, Vol. 10, No. 6, e0129423, 2015.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Non-Linear Concentration-Response Relationships between Ambient Ozone and Daily Mortality
AU - Bae, Sanghyuk
AU - Lim, Youn-Hee
AU - Kashima, Saori
AU - Yorifuji, Takashi
AU - Honda, Yasushi
AU - Kim, Ho
AU - Hong, Yun-Chul
PY - 2015
Y1 - 2015
N2 - BACKGROUND: Ambient ozone (O3) concentration has been reported to be significantly associated with mortality. However, linearity of the relationships and the presence of a threshold has been controversial.OBJECTIVES: The aim of the present study was to examine the concentration-response relationship and threshold of the association between ambient O3 concentration and non-accidental mortality in 13 Japanese and Korean cities from 2000 to 2009.METHODS: We selected Japanese and Korean cities which have population of over 1 million. We constructed Poisson regression models adjusting daily mean temperature, daily mean PM10, humidity, time trend, season, year, day of the week, holidays and yearly population. The association between O3 concentration and mortality was examined using linear, spline and linear-threshold models. The thresholds were estimated for each city, by constructing linear-threshold models. We also examined the city-combined association using a generalized additive mixed model.RESULTS: The mean O3 concentration did not differ greatly between Korea and Japan, which were 26.2 ppb and 24.2 ppb, respectively. Seven out of 13 cities showed better fits for the spline model compared with the linear model, supporting a non-linear relationships between O3 concentration and mortality. All of the 7 cities showed J or U shaped associations suggesting the existence of thresholds. The range of city-specific thresholds was from 11 to 34 ppb. The city-combined analysis also showed a non-linear association with a threshold around 30-40 ppb.CONCLUSION: We have observed non-linear concentration-response relationship with thresholds between daily mean ambient O3 concentration and daily number of non-accidental death in Japanese and Korean cities.
AB - BACKGROUND: Ambient ozone (O3) concentration has been reported to be significantly associated with mortality. However, linearity of the relationships and the presence of a threshold has been controversial.OBJECTIVES: The aim of the present study was to examine the concentration-response relationship and threshold of the association between ambient O3 concentration and non-accidental mortality in 13 Japanese and Korean cities from 2000 to 2009.METHODS: We selected Japanese and Korean cities which have population of over 1 million. We constructed Poisson regression models adjusting daily mean temperature, daily mean PM10, humidity, time trend, season, year, day of the week, holidays and yearly population. The association between O3 concentration and mortality was examined using linear, spline and linear-threshold models. The thresholds were estimated for each city, by constructing linear-threshold models. We also examined the city-combined association using a generalized additive mixed model.RESULTS: The mean O3 concentration did not differ greatly between Korea and Japan, which were 26.2 ppb and 24.2 ppb, respectively. Seven out of 13 cities showed better fits for the spline model compared with the linear model, supporting a non-linear relationships between O3 concentration and mortality. All of the 7 cities showed J or U shaped associations suggesting the existence of thresholds. The range of city-specific thresholds was from 11 to 34 ppb. The city-combined analysis also showed a non-linear association with a threshold around 30-40 ppb.CONCLUSION: We have observed non-linear concentration-response relationship with thresholds between daily mean ambient O3 concentration and daily number of non-accidental death in Japanese and Korean cities.
KW - Environmental Monitoring
KW - Humans
KW - Japan/epidemiology
KW - Mortality
KW - Nonlinear Dynamics
KW - Ozone/analysis
KW - Republic of Korea/epidemiology
U2 - 10.1371/journal.pone.0129423
DO - 10.1371/journal.pone.0129423
M3 - Journal article
C2 - 26076447
VL - 10
JO - PLoS ONE
JF - PLoS ONE
SN - 1932-6203
IS - 6
M1 - e0129423
ER -
ID: 230070391