Prenatal TVOCs exposure negatively influences postnatal neurobehavioral development
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Prenatal TVOCs exposure negatively influences postnatal neurobehavioral development. / Chang, Moonhee; Lee, Dongheon; Park, Hyesook; Ha, Mina; Hong, Yun-Chul; Kim, Yangho; Kim, Boong-Nyun; Kim, Yeni; Lim, Youn-Hee; Ha, Eun-Hee.
In: The Science of the Total Environment, Vol. 618, 2018, p. 977-981.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Prenatal TVOCs exposure negatively influences postnatal neurobehavioral development
AU - Chang, Moonhee
AU - Lee, Dongheon
AU - Park, Hyesook
AU - Ha, Mina
AU - Hong, Yun-Chul
AU - Kim, Yangho
AU - Kim, Boong-Nyun
AU - Kim, Yeni
AU - Lim, Youn-Hee
AU - Ha, Eun-Hee
N1 - Copyright © 2017 Elsevier B.V. All rights reserved.
PY - 2018
Y1 - 2018
N2 - Prenatal exposure to volatile organic compounds may restrict fetal development and adversely influence infants' life. Therefore, we investigated the relationship between prenatal exposure to total volatile organic compounds (TVOC) and postnatal neurobehavioral development. A subsample of 383 pregnant participants was chosen from the prospective birth cohort study of Mother and Children's Environmental Health Study; MOCEH (N=1,751) from three regions of the Republic of Korea (Seoul, Cheon-an, and Ulsan). Participants were enrolled during their first trimester with informed consent. We investigated maternal characteristics including socio-economic and obstetrical history using questionnaires. An environmental hygienist measured participating mothers' personal TVOC exposure using passive samplers during pregnancy. Participants visited the research center at 6, 12, 24 and 36 months. At each visit, questionnaires about infantile environment and health conditions were answered and a neurobehavioral test (BSID-II) was conducted by certified investigators. We conducted multiple general linear and mixed model analyses to investigate the relationship between TVOC and infantile neurobehavioral development (SAS 9.3). Mean prenatal TVOC exposure was 284.2μg/m3. In longitudinal analyses on infantile neurobehavioral development, adjusted mean psychomotor development index and mental developmental index scores in high TVOC exposure group (cut off at Q3: 374.0 ug/m3) were 3 points lower than the low exposure group. Results suggested exposure to higher TVOC during the fetal period may adversely influence neurobehavioral development in the early life stage.
AB - Prenatal exposure to volatile organic compounds may restrict fetal development and adversely influence infants' life. Therefore, we investigated the relationship between prenatal exposure to total volatile organic compounds (TVOC) and postnatal neurobehavioral development. A subsample of 383 pregnant participants was chosen from the prospective birth cohort study of Mother and Children's Environmental Health Study; MOCEH (N=1,751) from three regions of the Republic of Korea (Seoul, Cheon-an, and Ulsan). Participants were enrolled during their first trimester with informed consent. We investigated maternal characteristics including socio-economic and obstetrical history using questionnaires. An environmental hygienist measured participating mothers' personal TVOC exposure using passive samplers during pregnancy. Participants visited the research center at 6, 12, 24 and 36 months. At each visit, questionnaires about infantile environment and health conditions were answered and a neurobehavioral test (BSID-II) was conducted by certified investigators. We conducted multiple general linear and mixed model analyses to investigate the relationship between TVOC and infantile neurobehavioral development (SAS 9.3). Mean prenatal TVOC exposure was 284.2μg/m3. In longitudinal analyses on infantile neurobehavioral development, adjusted mean psychomotor development index and mental developmental index scores in high TVOC exposure group (cut off at Q3: 374.0 ug/m3) were 3 points lower than the low exposure group. Results suggested exposure to higher TVOC during the fetal period may adversely influence neurobehavioral development in the early life stage.
KW - Adult
KW - Child Development/drug effects
KW - Child, Preschool
KW - Female
KW - Humans
KW - Infant
KW - Maternal Exposure/adverse effects
KW - Pregnancy
KW - Prenatal Exposure Delayed Effects/physiopathology
KW - Prospective Studies
KW - Republic of Korea
KW - Seoul
KW - Volatile Organic Compounds/adverse effects
U2 - 10.1016/j.scitotenv.2017.09.046
DO - 10.1016/j.scitotenv.2017.09.046
M3 - Journal article
C2 - 29153381
VL - 618
SP - 977
EP - 981
JO - Science of the Total Environment
JF - Science of the Total Environment
SN - 0048-9697
ER -
ID: 230068454