Pulmonary function of healthy Korean children from 3 independent birth cohorts: validation of the Global Lung function Initiative (GLI) 2012 equation

Research output: Contribution to journalJournal articleResearchpeer-review


  • Fulltext

    Accepted author manuscript, 795 KB, PDF document

  • Ji Soo Park
  • Dong In Suh
  • Yun Jung Choi
  • Kangmo Ahn
  • Kyung Won Kim
  • Youn Ho Shin
  • So-Yeon Lee
  • Hyun-Ju Cho
  • Eun Lee
  • Gwang Cheon Jang
  • Ji-Won Kwon
  • Yong Han Sun
  • Sung-Il Woo
  • You-Sook Youn
  • Kang Seo Park
  • Myung-Hee Kook
  • Hwa Jin Cho
  • Hai Lee Chung
  • Ja Hyung Kim
  • Hyung Young Kim
  • Jin A Jung
  • Hyang-Ok Woo
  • Yoon Kyung Choi
  • Jeong Rim Lee
  • Young Ah Lee
  • Choong Ho Shin
  • Boong Nyun Kim
  • Johanna Inhyang Kim
  • Kyung-Shin Lee
  • Yun-Chul Hong
  • Soo-Jong Hong
Background and objective Global Lung Function Initiative (GLI) 2012 equations were developed to resolve the age-related disparity in interpreting spirometry results. Local validation of the equation is needed, especially in Northeast Asian children. This study evaluated the GLI equation in Korean children. Methods Spirometry indices (FEV1, FVC, FEV1/FVC and FEF25-75 and clinical information were gathered from three population-based birth cohorts. Predicted GLI reference values and z-scores of spirometry results were calculated for 1239 healthy children. The mean, standard deviation of z-scores were compared to the expected 0 and 1. Probabilities of falling below the lower limit of normal [LLN] (z-score: -1.64) were compared to the expected value 5scores were assessed according to low (2) BMI z-score groups. Results Mean z-scores significantly differed from 0 for FEV1/FVC in males (mean [95: 0.18 [0.08, 0.27]) and FEV1 and FVC in females (-0.23 [-0.31, -0.15] and -0.26 [-0.36, -0.16], respectively). The standard deviation was larger than 1 for all variables in males and FVC and FEV1/FVC in females. The probability of falling below the LLN was significantly larger than 5 (12.139.64, 14.77]), FVC (15.8613.06, 18.81]), and FEF25–757.315.29, 9.49]) in males and FVC (11.919.40, 14.60]) in females. FEV1 and FVC z-scores increased across low to high BMI groups, and FEV1/FVC decreased from low to high BMI groups. Conclusion GLI equations marginally differ from real-world values, which should be considered by pulmonologists in practice or research.
Original languageEnglish
JournalPediatric Pulmonology
Issue number10
Pages (from-to)3310-3320
Number of pages11
Publication statusPublished - 2021

    Research areas

  • Asian, Children, Global Lung Function Initiative, Reference equation, Spirometry

Number of downloads are based on statistics from Google Scholar and www.ku.dk

No data available

ID: 276230675