A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort

Research output: Contribution to journal › Journal article › Research › peer-review

Standard

A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity : results from a large European cohort. / Christakoudi, Sofia; Tsilidis, Konstantinos K.; Muller, David C.; Freisling, Heinz; Weiderpass, Elisabete; Overvad, Kim; Söderberg, Stefan; Häggström, Christel; Pischon, Tobias; Dahm, Christina C.; Zhang, Jie; Tjønneland, Anne; Halkjær, Jytte; MacDonald, Conor; Boutron-Ruault, Marie Christine; Mancini, Francesca Romana; Kühn, Tilman; Kaaks, Rudolf; Schulze, Matthias B.; Trichopoulou, Antonia; Karakatsani, Anna; Peppa, Eleni; Masala, Giovanna; Pala, Valeria; Panico, Salvatore; Tumino, Rosario; Sacerdote, Carlotta; Quirós, J. Ramón; Agudo, Antonio; Sánchez, Maria Jose; Cirera, Lluís; Barricarte-Gurrea, Aurelio; Amiano, Pilar; Memarian, Ensieh; Sonestedt, Emily; Bueno-de-Mesquita, Bas; May, Anne M.; Khaw, Kay Tee; Wareham, Nicholas J.; Tong, Tammy Y.N.; Huybrechts, Inge; Noh, Hwayoung; Aglago, Elom K.; Ellingjord-Dale, Merete; Ward, Heather A.; Aune, Dagfinn; Riboli, Elio.

In: Scientific Reports, Vol. 10, No. 1, 14541, 2020.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Christakoudi, S, Tsilidis, KK, Muller, DC, Freisling, H, Weiderpass, E, Overvad, K, Söderberg, S, Häggström, C, Pischon, T, Dahm, CC, Zhang, J, Tjønneland, A, Halkjær, J, MacDonald, C, Boutron-Ruault, MC, Mancini, FR, Kühn, T, Kaaks, R, Schulze, MB, Trichopoulou, A, Karakatsani, A, Peppa, E, Masala, G, Pala, V, Panico, S, Tumino, R, Sacerdote, C, Quirós, JR, Agudo, A, Sánchez, MJ, Cirera, L, Barricarte-Gurrea, A, Amiano, P, Memarian, E, Sonestedt, E, Bueno-de-Mesquita, B, May, AM, Khaw, KT, Wareham, NJ, Tong, TYN, Huybrechts, I, Noh, H, Aglago, EK, Ellingjord-Dale, M, Ward, HA, Aune, D & Riboli, E 2020, 'A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort', Scientific Reports, vol. 10, no. 1, 14541. https://doi.org/10.1038/s41598-020-71302-5

APA

Christakoudi, S., Tsilidis, K. K., Muller, D. C., Freisling, H., Weiderpass, E., Overvad, K., Söderberg, S., Häggström, C., Pischon, T., Dahm, C. C., Zhang, J., Tjønneland, A., Halkjær, J., MacDonald, C., Boutron-Ruault, M. C., Mancini, F. R., Kühn, T., Kaaks, R., Schulze, M. B., ... Riboli, E. (2020). A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort. Scientific Reports, 10(1), [14541]. https://doi.org/10.1038/s41598-020-71302-5

Vancouver

Christakoudi S, Tsilidis KK, Muller DC, Freisling H, Weiderpass E, Overvad K et al. A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort. Scientific Reports. 2020;10(1). 14541. https://doi.org/10.1038/s41598-020-71302-5

Author

Christakoudi, Sofia ; Tsilidis, Konstantinos K. ; Muller, David C. ; Freisling, Heinz ; Weiderpass, Elisabete ; Overvad, Kim ; Söderberg, Stefan ; Häggström, Christel ; Pischon, Tobias ; Dahm, Christina C. ; Zhang, Jie ; Tjønneland, Anne ; Halkjær, Jytte ; MacDonald, Conor ; Boutron-Ruault, Marie Christine ; Mancini, Francesca Romana ; Kühn, Tilman ; Kaaks, Rudolf ; Schulze, Matthias B. ; Trichopoulou, Antonia ; Karakatsani, Anna ; Peppa, Eleni ; Masala, Giovanna ; Pala, Valeria ; Panico, Salvatore ; Tumino, Rosario ; Sacerdote, Carlotta ; Quirós, J. Ramón ; Agudo, Antonio ; Sánchez, Maria Jose ; Cirera, Lluís ; Barricarte-Gurrea, Aurelio ; Amiano, Pilar ; Memarian, Ensieh ; Sonestedt, Emily ; Bueno-de-Mesquita, Bas ; May, Anne M. ; Khaw, Kay Tee ; Wareham, Nicholas J. ; Tong, Tammy Y.N. ; Huybrechts, Inge ; Noh, Hwayoung ; Aglago, Elom K. ; Ellingjord-Dale, Merete ; Ward, Heather A. ; Aune, Dagfinn ; Riboli, Elio. / A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity : results from a large European cohort. In: Scientific Reports. 2020 ; Vol. 10, No. 1.

Bibtex

@article{ac148555602b4ac4b8f3fd931f08bb02,
title = "A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity: results from a large European cohort",
abstract = "Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI < 18.5 kg/m2) or obese (BMI ≥ 30 kg/m2) categories, while the highest quartile of ABSI separated 18–39% of the individuals within each BMI category, which had 22–55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.",
author = "Sofia Christakoudi and Tsilidis, {Konstantinos K.} and Muller, {David C.} and Heinz Freisling and Elisabete Weiderpass and Kim Overvad and Stefan S{\"o}derberg and Christel H{\"a}ggstr{\"o}m and Tobias Pischon and Dahm, {Christina C.} and Jie Zhang and Anne Tj{\o}nneland and Jytte Halkj{\ae}r and Conor MacDonald and Boutron-Ruault, {Marie Christine} and Mancini, {Francesca Romana} and Tilman K{\"u}hn and Rudolf Kaaks and Schulze, {Matthias B.} and Antonia Trichopoulou and Anna Karakatsani and Eleni Peppa and Giovanna Masala and Valeria Pala and Salvatore Panico and Rosario Tumino and Carlotta Sacerdote and Quir{\'o}s, {J. Ram{\'o}n} and Antonio Agudo and S{\'a}nchez, {Maria Jose} and Llu{\'i}s Cirera and Aurelio Barricarte-Gurrea and Pilar Amiano and Ensieh Memarian and Emily Sonestedt and Bas Bueno-de-Mesquita and May, {Anne M.} and Khaw, {Kay Tee} and Wareham, {Nicholas J.} and Tong, {Tammy Y.N.} and Inge Huybrechts and Hwayoung Noh and Aglago, {Elom K.} and Merete Ellingjord-Dale and Ward, {Heather A.} and Dagfinn Aune and Elio Riboli",
year = "2020",
doi = "10.1038/s41598-020-71302-5",
language = "English",
volume = "10",
journal = "Scientific Reports",
issn = "2045-2322",
publisher = "nature publishing group",
number = "1",

}

RIS

TY - JOUR

T1 - A Body Shape Index (ABSI) achieves better mortality risk stratification than alternative indices of abdominal obesity

T2 - results from a large European cohort

AU - Christakoudi, Sofia

AU - Tsilidis, Konstantinos K.

AU - Muller, David C.

AU - Freisling, Heinz

AU - Weiderpass, Elisabete

AU - Overvad, Kim

AU - Söderberg, Stefan

AU - Häggström, Christel

AU - Pischon, Tobias

AU - Dahm, Christina C.

AU - Zhang, Jie

AU - Tjønneland, Anne

AU - Halkjær, Jytte

AU - MacDonald, Conor

AU - Boutron-Ruault, Marie Christine

AU - Mancini, Francesca Romana

AU - Kühn, Tilman

AU - Kaaks, Rudolf

AU - Schulze, Matthias B.

AU - Trichopoulou, Antonia

AU - Karakatsani, Anna

AU - Peppa, Eleni

AU - Masala, Giovanna

AU - Pala, Valeria

AU - Panico, Salvatore

AU - Tumino, Rosario

AU - Sacerdote, Carlotta

AU - Quirós, J. Ramón

AU - Agudo, Antonio

AU - Sánchez, Maria Jose

AU - Cirera, Lluís

AU - Barricarte-Gurrea, Aurelio

AU - Amiano, Pilar

AU - Memarian, Ensieh

AU - Sonestedt, Emily

AU - Bueno-de-Mesquita, Bas

AU - May, Anne M.

AU - Khaw, Kay Tee

AU - Wareham, Nicholas J.

AU - Tong, Tammy Y.N.

AU - Huybrechts, Inge

AU - Noh, Hwayoung

AU - Aglago, Elom K.

AU - Ellingjord-Dale, Merete

AU - Ward, Heather A.

AU - Aune, Dagfinn

AU - Riboli, Elio

PY - 2020

Y1 - 2020

N2 - Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI < 18.5 kg/m2) or obese (BMI ≥ 30 kg/m2) categories, while the highest quartile of ABSI separated 18–39% of the individuals within each BMI category, which had 22–55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.

AB - Abdominal and general adiposity are independently associated with mortality, but there is no consensus on how best to assess abdominal adiposity. We compared the ability of alternative waist indices to complement body mass index (BMI) when assessing all-cause mortality. We used data from 352,985 participants in the European Prospective Investigation into Cancer and Nutrition (EPIC) and Cox proportional hazards models adjusted for other risk factors. During a mean follow-up of 16.1 years, 38,178 participants died. Combining in one model BMI and a strongly correlated waist index altered the association patterns with mortality, to a predominantly negative association for BMI and a stronger positive association for the waist index, while combining BMI with the uncorrelated A Body Shape Index (ABSI) preserved the association patterns. Sex-specific cohort-wide quartiles of waist indices correlated with BMI could not separate high-risk from low-risk individuals within underweight (BMI < 18.5 kg/m2) or obese (BMI ≥ 30 kg/m2) categories, while the highest quartile of ABSI separated 18–39% of the individuals within each BMI category, which had 22–55% higher risk of death. In conclusion, only a waist index independent of BMI by design, such as ABSI, complements BMI and enables efficient risk stratification, which could facilitate personalisation of screening, treatment and monitoring.

U2 - 10.1038/s41598-020-71302-5

DO - 10.1038/s41598-020-71302-5

M3 - Journal article

C2 - 32883969

AN - SCOPUS:85090137097

VL - 10

JO - Scientific Reports

JF - Scientific Reports

SN - 2045-2322

IS - 1

M1 - 14541

ER -

ID: 249765626