A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections

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A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections. / Hersoug, Lars-Georg; Arnau, José.

In: Medical Hypotheses, Vol. 68, No. 5, 2007, p. 1001-8.

Research output: Contribution to journal › Journal article › Research › peer-review

Harvard

Hersoug, L-G & Arnau, J 2007, 'A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections', Medical Hypotheses, vol. 68, no. 5, pp. 1001-8. https://doi.org/10.1016/j.mehy.2006.10.009

APA

Hersoug, L-G., & Arnau, J. (2007). A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections. Medical Hypotheses, 68(5), 1001-8. https://doi.org/10.1016/j.mehy.2006.10.009

Vancouver

Hersoug L-G, Arnau J. A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections. Medical Hypotheses. 2007;68(5):1001-8. https://doi.org/10.1016/j.mehy.2006.10.009

Author

Hersoug, Lars-Georg ; Arnau, José. / A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections. In: Medical Hypotheses. 2007 ; Vol. 68, No. 5. pp. 1001-8.

Bibtex

@article{86cdaa41c3c94117b1904c29e430ec59,
title = "A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections",
abstract = "A new hypothesis for some cancers, which combines the chromosomal instability theories with a co-carcinogenic effect of viruses causing latent or persistent infection, is presented. The hypothesis incorporates the multi-step model of cancer and that pre-cancerous cells reach a state of chromosomal instability. Because of chromosomal instability, the genome of these cell lines will lead to changes from generation to generation and will face a remarkable selection pressure both from lost traits, apoptosis, and from the immune system. Viruses causing latent or persistent infections have evolved many different genes capable to evade the immune system. If these viruses are harboured in the genome of pre-cancerous cells they could provide them with {"}superpowers{"} and with genes that may assist the cells to elude the immune system. The theory explains why cancer predominantly is a disease of old age. Upon aging, the immune system becomes reduced including the ability to control and suppress the viruses that cause latent or persistent infections. The risk of cancer could thereby increase as the immune functions decrease. The theory provides new insights to the genesis of cancers.",
keywords = "Animals, Chronic Disease, Communicable Diseases, Humans, Models, Biological, Neoplasms, Virus Latency, Virus Physiological Phenomena, Viruses",
author = "Lars-Georg Hersoug and Jos{\'e} Arnau",
year = "2007",
doi = "10.1016/j.mehy.2006.10.009",
language = "English",
volume = "68",
pages = "1001--8",
journal = "Medical Hypotheses",
issn = "0306-9877",
publisher = "Churchill Livingstone",
number = "5",

}

RIS

TY - JOUR

T1 - A built-in co-carcinogenic effect due to viruses involved in latent or persistent infections

AU - Hersoug, Lars-Georg

AU - Arnau, José

PY - 2007

Y1 - 2007

N2 - A new hypothesis for some cancers, which combines the chromosomal instability theories with a co-carcinogenic effect of viruses causing latent or persistent infection, is presented. The hypothesis incorporates the multi-step model of cancer and that pre-cancerous cells reach a state of chromosomal instability. Because of chromosomal instability, the genome of these cell lines will lead to changes from generation to generation and will face a remarkable selection pressure both from lost traits, apoptosis, and from the immune system. Viruses causing latent or persistent infections have evolved many different genes capable to evade the immune system. If these viruses are harboured in the genome of pre-cancerous cells they could provide them with "superpowers" and with genes that may assist the cells to elude the immune system. The theory explains why cancer predominantly is a disease of old age. Upon aging, the immune system becomes reduced including the ability to control and suppress the viruses that cause latent or persistent infections. The risk of cancer could thereby increase as the immune functions decrease. The theory provides new insights to the genesis of cancers.

AB - A new hypothesis for some cancers, which combines the chromosomal instability theories with a co-carcinogenic effect of viruses causing latent or persistent infection, is presented. The hypothesis incorporates the multi-step model of cancer and that pre-cancerous cells reach a state of chromosomal instability. Because of chromosomal instability, the genome of these cell lines will lead to changes from generation to generation and will face a remarkable selection pressure both from lost traits, apoptosis, and from the immune system. Viruses causing latent or persistent infections have evolved many different genes capable to evade the immune system. If these viruses are harboured in the genome of pre-cancerous cells they could provide them with "superpowers" and with genes that may assist the cells to elude the immune system. The theory explains why cancer predominantly is a disease of old age. Upon aging, the immune system becomes reduced including the ability to control and suppress the viruses that cause latent or persistent infections. The risk of cancer could thereby increase as the immune functions decrease. The theory provides new insights to the genesis of cancers.

KW - Animals

KW - Chronic Disease

KW - Communicable Diseases

KW - Humans

KW - Models, Biological

KW - Neoplasms

KW - Virus Latency

KW - Virus Physiological Phenomena

KW - Viruses

U2 - 10.1016/j.mehy.2006.10.009

DO - 10.1016/j.mehy.2006.10.009

M3 - Journal article

C2 - 17125934

VL - 68

SP - 1001

EP - 1008

JO - Medical Hypotheses

JF - Medical Hypotheses

SN - 0306-9877

IS - 5

ER -

ID: 45422517