A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans

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A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. / Erritzoe, David; Holst, Klaus; Frokjaer, Vibe G; Licht, Cecilie Löe; Kalbitzer, Jan; Nielsen, Finn A; Svarer, Claus; Madsen, Jacob; Knudsen, Gitte.

In: Journal of Neuroscience, Vol. 30, No. 9, 03.03.2010, p. 3391-7.

Research output: Contribution to journalJournal articleResearchpeer-review

Harvard

Erritzoe, D, Holst, K, Frokjaer, VG, Licht, CL, Kalbitzer, J, Nielsen, FA, Svarer, C, Madsen, J & Knudsen, G 2010, 'A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans', Journal of Neuroscience, vol. 30, no. 9, pp. 3391-7. https://doi.org/10.1523/JNEUROSCI.2852-09.2010, https://doi.org/10.1523/JNEUROSCI.2852-09.2010

APA

Erritzoe, D., Holst, K., Frokjaer, V. G., Licht, C. L., Kalbitzer, J., Nielsen, F. A., ... Knudsen, G. (2010). A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. Journal of Neuroscience, 30(9), 3391-7. https://doi.org/10.1523/JNEUROSCI.2852-09.2010, https://doi.org/10.1523/JNEUROSCI.2852-09.2010

Vancouver

Erritzoe D, Holst K, Frokjaer VG, Licht CL, Kalbitzer J, Nielsen FA et al. A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. Journal of Neuroscience. 2010 Mar 3;30(9):3391-7. https://doi.org/10.1523/JNEUROSCI.2852-09.2010, https://doi.org/10.1523/JNEUROSCI.2852-09.2010

Author

Erritzoe, David ; Holst, Klaus ; Frokjaer, Vibe G ; Licht, Cecilie Löe ; Kalbitzer, Jan ; Nielsen, Finn A ; Svarer, Claus ; Madsen, Jacob ; Knudsen, Gitte. / A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans. In: Journal of Neuroscience. 2010 ; Vol. 30, No. 9. pp. 3391-7.

Bibtex

@article{2d0a5d308b5111df928f000ea68e967b,
title = "A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans",
abstract = "Serotonergic neurotransmission is involved in the regulation of physiological functions such as mood, sleep, memory, and appetite. Within the serotonin transmitter system, both the postsynaptically located serotonin 2A (5-HT(2A)) receptor and the presynaptic serotonin transporter (SERT) are sensitive to chronic changes in cerebral 5-HT levels. Additionally, experimental studies suggest that alterations in either the 5-HT(2A) receptor or SERT level can affect the protein level of the counterpart. The aim of this study was to explore the covariation between cerebral 5-HT(2A) receptor and SERT in vivo in the same healthy human subjects. Fifty-six healthy human subjects with a mean age of 36 +/- 19 years were investigated. The SERT binding was imaged with [(11)C]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB) and 5-HT(2A) receptor binding with [(18)F]altanserin using positron emission tomography. Within each individual, a regional intercorrelation for the various brain regions was seen with both markers, most notably for 5-HT(2A) receptor binding. An inverted U-shaped relationship between the 5-HT(2A) receptor and the SERT binding was identified. The observed regional intercorrelation for both the 5-HT(2A) receptor and the SERT cerebral binding suggests that, within the single individual, each marker has a set point adjusted through a common regulator. A quadratic relationship between the two markers is consistent with data from experimental studies of the effect on SERT and 5-HT(2A) receptor binding of chronic changes in 5-HT levels. That is, the observed association between the 5-HT(2A) receptor and SERT binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand.",
author = "David Erritzoe and Klaus Holst and Frokjaer, {Vibe G} and Licht, {Cecilie L{\"o}e} and Jan Kalbitzer and Nielsen, {Finn A} and Claus Svarer and Jacob Madsen and Gitte Knudsen",
note = "Keywords: Adult; Aged; Aged, 80 and over; Benzylamines; Binding, Competitive; Brain Chemistry; Brain Mapping; Cerebral Cortex; Computer Simulation; Female; Humans; Ketanserin; Male; Middle Aged; Positron-Emission Tomography; Radioisotopes; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission; Young Adult",
year = "2010",
month = "3",
day = "3",
doi = "10.1523/JNEUROSCI.2852-09.2010",
language = "English",
volume = "30",
pages = "3391--7",
journal = "The Journal of neuroscience : the official journal of the Society for Neuroscience",
issn = "0270-6474",
publisher = "Society for Neuroscience",
number = "9",

}

RIS

TY - JOUR

T1 - A nonlinear relationship between cerebral serotonin transporter and 5-HT(2A) receptor binding: an in vivo molecular imaging study in humans

AU - Erritzoe, David

AU - Holst, Klaus

AU - Frokjaer, Vibe G

AU - Licht, Cecilie Löe

AU - Kalbitzer, Jan

AU - Nielsen, Finn A

AU - Svarer, Claus

AU - Madsen, Jacob

AU - Knudsen, Gitte

N1 - Keywords: Adult; Aged; Aged, 80 and over; Benzylamines; Binding, Competitive; Brain Chemistry; Brain Mapping; Cerebral Cortex; Computer Simulation; Female; Humans; Ketanserin; Male; Middle Aged; Positron-Emission Tomography; Radioisotopes; Radioligand Assay; Receptor, Serotonin, 5-HT2A; Serotonin; Serotonin Plasma Membrane Transport Proteins; Synaptic Transmission; Young Adult

PY - 2010/3/3

Y1 - 2010/3/3

N2 - Serotonergic neurotransmission is involved in the regulation of physiological functions such as mood, sleep, memory, and appetite. Within the serotonin transmitter system, both the postsynaptically located serotonin 2A (5-HT(2A)) receptor and the presynaptic serotonin transporter (SERT) are sensitive to chronic changes in cerebral 5-HT levels. Additionally, experimental studies suggest that alterations in either the 5-HT(2A) receptor or SERT level can affect the protein level of the counterpart. The aim of this study was to explore the covariation between cerebral 5-HT(2A) receptor and SERT in vivo in the same healthy human subjects. Fifty-six healthy human subjects with a mean age of 36 +/- 19 years were investigated. The SERT binding was imaged with [(11)C]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB) and 5-HT(2A) receptor binding with [(18)F]altanserin using positron emission tomography. Within each individual, a regional intercorrelation for the various brain regions was seen with both markers, most notably for 5-HT(2A) receptor binding. An inverted U-shaped relationship between the 5-HT(2A) receptor and the SERT binding was identified. The observed regional intercorrelation for both the 5-HT(2A) receptor and the SERT cerebral binding suggests that, within the single individual, each marker has a set point adjusted through a common regulator. A quadratic relationship between the two markers is consistent with data from experimental studies of the effect on SERT and 5-HT(2A) receptor binding of chronic changes in 5-HT levels. That is, the observed association between the 5-HT(2A) receptor and SERT binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand.

AB - Serotonergic neurotransmission is involved in the regulation of physiological functions such as mood, sleep, memory, and appetite. Within the serotonin transmitter system, both the postsynaptically located serotonin 2A (5-HT(2A)) receptor and the presynaptic serotonin transporter (SERT) are sensitive to chronic changes in cerebral 5-HT levels. Additionally, experimental studies suggest that alterations in either the 5-HT(2A) receptor or SERT level can affect the protein level of the counterpart. The aim of this study was to explore the covariation between cerebral 5-HT(2A) receptor and SERT in vivo in the same healthy human subjects. Fifty-six healthy human subjects with a mean age of 36 +/- 19 years were investigated. The SERT binding was imaged with [(11)C]3-amino-4-(2-dimethylaminomethyl-phenylsulfanyl)-benzonitrile (DASB) and 5-HT(2A) receptor binding with [(18)F]altanserin using positron emission tomography. Within each individual, a regional intercorrelation for the various brain regions was seen with both markers, most notably for 5-HT(2A) receptor binding. An inverted U-shaped relationship between the 5-HT(2A) receptor and the SERT binding was identified. The observed regional intercorrelation for both the 5-HT(2A) receptor and the SERT cerebral binding suggests that, within the single individual, each marker has a set point adjusted through a common regulator. A quadratic relationship between the two markers is consistent with data from experimental studies of the effect on SERT and 5-HT(2A) receptor binding of chronic changes in 5-HT levels. That is, the observed association between the 5-HT(2A) receptor and SERT binding could be driven by the projection output from the raphe nuclei, but other explanations are also at hand.

U2 - 10.1523/JNEUROSCI.2852-09.2010

DO - 10.1523/JNEUROSCI.2852-09.2010

M3 - Journal article

C2 - 20203198

VL - 30

SP - 3391

EP - 3397

JO - The Journal of neuroscience : the official journal of the Society for Neuroscience

JF - The Journal of neuroscience : the official journal of the Society for Neuroscience

SN - 0270-6474

IS - 9

ER -

ID: 20738194