TY - JOUR

T1 - Acute differences in pulse wave velocity, augmentation index, and central pulse pressure following controlled exposures to cookstove air pollution in the Subclinical Tests of Volunteers Exposed to Smoke (SToVES) study

AU - Walker, Ethan S.

AU - Fedak, Kristen M.

AU - Good, Nicholas

AU - Balmes, John

AU - Brook, Robert D.

AU - Clark, Maggie L.

AU - Cole-Hunter, Tom

AU - Dinenno, Frank

AU - Devlin, Robert B.

AU - L'Orange, Christian

AU - Luckasen, Gary

AU - Mehaffy, John

AU - Shelton, Rhiannon

AU - Wilson, Ander

AU - Volckens, John

AU - Peel, Jennifer L.

N1 - Funding Information: This work was supported by the National Institute of Environmental Health Sciences of the National Institutes of Health under grant number R01ES023688 (Principal Investigators: Jennifer L. Peel and John Volckens). Publisher Copyright: © 2019 Elsevier Inc.

PY - 2020

Y1 - 2020

N2 - Household air pollution emitted from solid-fuel cookstoves used for domestic cooking is a leading risk factor for morbidity and premature mortality globally. There have been attempts to design and distribute lower emission cookstoves, yet it is unclear if they meaningfully improve health. Using a crossover design, we assessed differences in central aortic hemodynamics and arterial stiffness following controlled exposures to air pollution emitted from five different cookstove technologies compared to a filtered air control. Forty-eight young, healthy participants were assigned to six 2-h controlled treatments of pollution from five different cookstoves and a filtered air control. Each treatment had a target concentration for fine particulate matter: filtered air control = 0 μg/m3, liquefied petroleum gas = 10 μg/m3, gasifier = 35 μg/m3, fan rocket = 100 μg/m3, rocket elbow = 250 μg/m3, three stone fire = 500 μg/m3. Pulse wave velocity (PWV), central augmentation index (AIx), and central pulse pressure (CPP) were measured before and at three time points after each treatment (0, 3, and 24 h). Linear mixed models were used to assess differences in the outcomes for each cookstove treatment compared to control. PWV and CPP were marginally higher 24 h after all cookstove treatments compared to control. For example, PWV was 0.15 m/s higher (95% confidence interval: −0.02, 0.31) and CPP was 0.6 mmHg higher (95% confidence interval: −0.8, 2.1) 24 h after the three stone fire treatment compared to control. The magnitude of the differences compared to control was similar across all cookstove treatments. PWV and CPP had no consistent trends at the other post-treatment time points (0 and 3 h). No consistent trends were observed for AIx at any post-treatment time point. Our findings suggest higher levels of PWV and CPP within 24 h after 2-h controlled treatments of pollution from five different cookstove technologies. The similar magnitude of the differences following each cookstove treatment compared to control may indicate that acute exposures from even the cleanest cookstove technologies can adversely impact these subclinical markers of cardiovascular health, although differences were small and may not be clinically meaningful.

AB - Household air pollution emitted from solid-fuel cookstoves used for domestic cooking is a leading risk factor for morbidity and premature mortality globally. There have been attempts to design and distribute lower emission cookstoves, yet it is unclear if they meaningfully improve health. Using a crossover design, we assessed differences in central aortic hemodynamics and arterial stiffness following controlled exposures to air pollution emitted from five different cookstove technologies compared to a filtered air control. Forty-eight young, healthy participants were assigned to six 2-h controlled treatments of pollution from five different cookstoves and a filtered air control. Each treatment had a target concentration for fine particulate matter: filtered air control = 0 μg/m3, liquefied petroleum gas = 10 μg/m3, gasifier = 35 μg/m3, fan rocket = 100 μg/m3, rocket elbow = 250 μg/m3, three stone fire = 500 μg/m3. Pulse wave velocity (PWV), central augmentation index (AIx), and central pulse pressure (CPP) were measured before and at three time points after each treatment (0, 3, and 24 h). Linear mixed models were used to assess differences in the outcomes for each cookstove treatment compared to control. PWV and CPP were marginally higher 24 h after all cookstove treatments compared to control. For example, PWV was 0.15 m/s higher (95% confidence interval: −0.02, 0.31) and CPP was 0.6 mmHg higher (95% confidence interval: −0.8, 2.1) 24 h after the three stone fire treatment compared to control. The magnitude of the differences compared to control was similar across all cookstove treatments. PWV and CPP had no consistent trends at the other post-treatment time points (0 and 3 h). No consistent trends were observed for AIx at any post-treatment time point. Our findings suggest higher levels of PWV and CPP within 24 h after 2-h controlled treatments of pollution from five different cookstove technologies. The similar magnitude of the differences following each cookstove treatment compared to control may indicate that acute exposures from even the cleanest cookstove technologies can adversely impact these subclinical markers of cardiovascular health, although differences were small and may not be clinically meaningful.

KW - Air pollution

KW - Arterial stiffness

KW - Biomass burning

KW - Central hemodynamics

KW - Epidemiology

U2 - 10.1016/j.envres.2019.108831

DO - 10.1016/j.envres.2019.108831

M3 - Journal article

C2 - 31648072

AN - SCOPUS:85073554070

VL - 180

JO - Environmental Research

JF - Environmental Research

SN - 0013-9351

M1 - 108831

ER -