Adherence to the EAT-Lancet Diet and Risk of Stroke and Stroke Subtypes: A Cohort Study
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Adherence to the EAT-Lancet Diet and Risk of Stroke and Stroke Subtypes : A Cohort Study. / Ibsen, Daniel B.; Christiansen, Anne H.; Olsen, Anja; Tjonneland, Anne; Overvad, Kim; Wolk, Alicja; Mortensen, Janne K.; Dahm, Christina C.
In: Stroke, Vol. 53, No. 1, 2022, p. 154-163.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Adherence to the EAT-Lancet Diet and Risk of Stroke and Stroke Subtypes
T2 - A Cohort Study
AU - Ibsen, Daniel B.
AU - Christiansen, Anne H.
AU - Olsen, Anja
AU - Tjonneland, Anne
AU - Overvad, Kim
AU - Wolk, Alicja
AU - Mortensen, Janne K.
AU - Dahm, Christina C.
PY - 2022
Y1 - 2022
N2 - Background and Purpose:We investigated the association between adherence to the EAT-Lancet diet, a sustainable and mostly plant-based diet, and risk of stroke and subtypes of stroke in a Danish population. For comparison, we also investigated the Alternate Healthy Eating Index-2010 (AHEI).Methods:We used the Danish Diet, Cancer and Health cohort (n=55 016) including adults aged 50 to 64 years at baseline (1993–1997). A food frequency questionnaire was used to assess dietary intake and group participants according to adherence to the diets. Stroke cases were identified using a national registry and subsequently validated by review of medical records (n=2253). Cox proportional hazards models were used to estimate hazard ratios and 95% CIs for associations with the EAT-Lancet diet or the AHEI and risk of stroke and stroke subtypes.Results:Adherence to the EAT-Lancet diet was associated with a lower risk of stroke, although not statistically significant (highest versus lowest adherence: hazard ratio, 0.91 [95% CI, 0.76–1.09]). A lower risk was observed for AHEI (0.75 [95% CI, 0.64–0.87]). For stroke subtypes, we found that adherence to the EAT-Lancet diet was associated with a lower risk of subarachnoid hemorrhage (0.30 [95% CI, 0.12–0.73]), and the AHEI was associated with a lower risk of ischemic stroke (0.76 [95% CI, 0.64–0.90]) and intracerebral hemorrhage (0.58 [95% CI, 0.36–0.93]).Conclusions:Adherence to the EAT-Lancet diet in midlife was associated with a lower risk of subarachnoid stroke, and the AHEI was associated with a lower risk of total stroke, mainly ischemic stroke and intracerebral hemorrhage.
AB - Background and Purpose:We investigated the association between adherence to the EAT-Lancet diet, a sustainable and mostly plant-based diet, and risk of stroke and subtypes of stroke in a Danish population. For comparison, we also investigated the Alternate Healthy Eating Index-2010 (AHEI).Methods:We used the Danish Diet, Cancer and Health cohort (n=55 016) including adults aged 50 to 64 years at baseline (1993–1997). A food frequency questionnaire was used to assess dietary intake and group participants according to adherence to the diets. Stroke cases were identified using a national registry and subsequently validated by review of medical records (n=2253). Cox proportional hazards models were used to estimate hazard ratios and 95% CIs for associations with the EAT-Lancet diet or the AHEI and risk of stroke and stroke subtypes.Results:Adherence to the EAT-Lancet diet was associated with a lower risk of stroke, although not statistically significant (highest versus lowest adherence: hazard ratio, 0.91 [95% CI, 0.76–1.09]). A lower risk was observed for AHEI (0.75 [95% CI, 0.64–0.87]). For stroke subtypes, we found that adherence to the EAT-Lancet diet was associated with a lower risk of subarachnoid hemorrhage (0.30 [95% CI, 0.12–0.73]), and the AHEI was associated with a lower risk of ischemic stroke (0.76 [95% CI, 0.64–0.90]) and intracerebral hemorrhage (0.58 [95% CI, 0.36–0.93]).Conclusions:Adherence to the EAT-Lancet diet in midlife was associated with a lower risk of subarachnoid stroke, and the AHEI was associated with a lower risk of total stroke, mainly ischemic stroke and intracerebral hemorrhage.
KW - adult
KW - aged
KW - cohort studies
KW - diet
KW - environment
KW - humans
U2 - 10.1161/STROKEAHA.121.036738
DO - 10.1161/STROKEAHA.121.036738
M3 - Journal article
C2 - 34872335
VL - 53
SP - 154
EP - 163
JO - Stroke
JF - Stroke
SN - 0039-2499
IS - 1
ER -
ID: 288777393