Adipose tissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancer risk in postmenopausal Danish women
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Adipose tissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancer risk in postmenopausal Danish women. / Bräuner, Elvira V; Loft, Steffen; Wellejus, Anja; Autrup, Herman; Tjønneland, Anne; Raaschou-Nielsen, Ole.
In: International Journal of Environmental Health Research, Vol. 24, No. 3, 2014, p. 256-68.Research output: Contribution to journal › Journal article › Research › peer-review
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TY - JOUR
T1 - Adipose tissue PCB levels and CYP1B1 and COMT genotypes in relation to breast cancer risk in postmenopausal Danish women
AU - Bräuner, Elvira V
AU - Loft, Steffen
AU - Wellejus, Anja
AU - Autrup, Herman
AU - Tjønneland, Anne
AU - Raaschou-Nielsen, Ole
PY - 2014
Y1 - 2014
N2 - Exposure to PCBs may be an etiologic factor for breast cancer. The cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) enzymes are involved in estrogen metabolism and PCB metabolism, both of which may relate to breast cancer susceptibility. Polymorphisms in genes regulating these enzymes control efficiency. Our objective was to assess whether CYP1B1 and COMT gene polymorphisms modulate the effect of PCBs in breast cancer risk, among postmenopausal Danish women. Neither CYP1B1 Leu432Val polymorphisms nor adipose tissue PCBs were independently associated with breast cancer risk. When assessing the independent effect of the COMT Val158Met polymorphism, we observed reduced risk for breast cancer amongst hormone replacement therapy using women who were homozygous carriers of the variant allele compared with those carrying the wild-type variant (RR = 0.41; 95% CI: 0.29-0.89). We found no statistically significant interactions between any of the PCB groups and CYP1B1 or COMT polymorphisms on the risk of breast cancer.
AB - Exposure to PCBs may be an etiologic factor for breast cancer. The cytochrome P450 1B1 (CYP1B1) and catechol-O-methyltransferase (COMT) enzymes are involved in estrogen metabolism and PCB metabolism, both of which may relate to breast cancer susceptibility. Polymorphisms in genes regulating these enzymes control efficiency. Our objective was to assess whether CYP1B1 and COMT gene polymorphisms modulate the effect of PCBs in breast cancer risk, among postmenopausal Danish women. Neither CYP1B1 Leu432Val polymorphisms nor adipose tissue PCBs were independently associated with breast cancer risk. When assessing the independent effect of the COMT Val158Met polymorphism, we observed reduced risk for breast cancer amongst hormone replacement therapy using women who were homozygous carriers of the variant allele compared with those carrying the wild-type variant (RR = 0.41; 95% CI: 0.29-0.89). We found no statistically significant interactions between any of the PCB groups and CYP1B1 or COMT polymorphisms on the risk of breast cancer.
KW - Adipose Tissue
KW - Aryl Hydrocarbon Hydroxylases
KW - Breast Neoplasms
KW - Case-Control Studies
KW - Catechol O-Methyltransferase
KW - Cytochrome P-450 CYP1B1
KW - Data Interpretation, Statistical
KW - Denmark
KW - Female
KW - Genotype
KW - Hormone Replacement Therapy
KW - Humans
KW - Middle Aged
KW - Polychlorinated Biphenyls
KW - Polymorphism, Single Nucleotide
KW - Postmenopause
KW - Prospective Studies
KW - Risk
U2 - 10.1080/09603123.2013.809703
DO - 10.1080/09603123.2013.809703
M3 - Journal article
C2 - 23869875
VL - 24
SP - 256
EP - 268
JO - International Journal of Environmental Health Research
JF - International Journal of Environmental Health Research
SN - 0960-3123
IS - 3
ER -
ID: 132418491